A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

Wallace B. Mendelson; Michael Cain; James M. Cook; Steven M. Paul; Phil Skolnick

doi:10.1126/science.6294835

A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

Wallace B. Mendelson
, Michael Cain
, James M. Cook
, Steven M. Paul
, Phil Skolnick

School of Medicine

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.

Original language	English
Pages (from-to)	414-416
Number of pages	3
Journal	Science
Volume	219
Issue number	4583
DOIs	https://doi.org/10.1126/science.6294835
State	Published - 1983

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abstract = "The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.",

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AB - The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.

UR - https://www.scopus.com/pages/publications/0020660276

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DO - 10.1126/science.6294835

M3 - Article

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ER -

A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

Abstract

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