A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

Wallace B. Mendelson; Michael Cain; James M. Cook; Steven M. Paul; Phil Skolnick

doi:10.1126/science.6294835

A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

Wallace B. Mendelson, Michael Cain, James M. Cook, Steven M. Paul, Phil Skolnick

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.

Original language	English
Pages (from-to)	414-416
Number of pages	3
Journal	Science
Volume	219
Issue number	4583
DOIs	https://doi.org/10.1126/science.6294835
State	Published - 1983

Access to Document

10.1126/science.6294835

Cite this

@article{b4ff9742986a42b78ed3eb91b41703e3,

title = "A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam",

abstract = "The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.",

author = "Mendelson, {Wallace B.} and Michael Cain and Cook, {James M.} and Paul, {Steven M.} and Phil Skolnick",

year = "1983",

doi = "10.1126/science.6294835",

language = "English",

volume = "219",

pages = "414--416",

journal = "Science",

issn = "0036-8075",

number = "4583",

}

TY - JOUR

T1 - A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

AU - Mendelson, Wallace B.

AU - Cain, Michael

AU - Cook, James M.

AU - Paul, Steven M.

AU - Skolnick, Phil

PY - 1983

Y1 - 1983

N2 - The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.

AB - The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.

UR - http://www.scopus.com/inward/record.url?scp=0020660276&partnerID=8YFLogxK

U2 - 10.1126/science.6294835

DO - 10.1126/science.6294835

M3 - Article

C2 - 6294835

AN - SCOPUS:0020660276

SN - 0036-8075

VL - 219

SP - 414

EP - 416

JO - Science

JF - Science

IS - 4583

ER -

A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

Abstract

Access to Document

Other files and links

Fingerprint

Cite this