A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

Wallace B. Mendelson, Michael Cain, James M. Cook, Steven M. Paul, Phil Skolnick

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The benzodiazepine receptor antagonist 3-hydroxymethyl-β-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-β-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.

Original languageEnglish
Pages (from-to)414-416
Number of pages3
JournalScience
Volume219
Issue number4583
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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