A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

E. Mauricio Barajas-Mora; Eden Kleiman; Jeffrey Xu; Nancy C. Carrico; Hanbin Lu; Eugene M. Oltz; Cornelis Murre; Ann J. Feeney

doi:10.1016/j.molcel.2018.10.013

A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

E. Mauricio Barajas-Mora
, Eden Kleiman
, Jeffrey Xu
, Nancy C. Carrico
, Hanbin Lu
, Eugene M. Oltz
, Cornelis Murre
, Ann J. Feeney

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.

Original language	English
Pages (from-to)	48-60.e5
Journal	Molecular cell
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2018.10.013
State	Published - Jan 3 2019

Keywords

3D structure
B cells
Igκ
V(D)J recombination
antibody repertoire
chromatin conformation capture
enhancer
long-range chromatin interactions
nuclear topology
subTAD

Access to Document

10.1016/j.molcel.2018.10.013

Cite this

@article{e7bb65a151cd490b9404c680ab5f5b00,

title = "A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire",

abstract = "Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.",

keywords = "3D structure, B cells, Igκ, V(D)J recombination, antibody repertoire, chromatin conformation capture, enhancer, long-range chromatin interactions, nuclear topology, subTAD",

author = "Barajas-Mora, \{E. Mauricio\} and Eden Kleiman and Jeffrey Xu and Carrico, \{Nancy C.\} and Hanbin Lu and Oltz, \{Eugene M.\} and Cornelis Murre and Feeney, \{Ann J.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = jan,

day = "3",

doi = "10.1016/j.molcel.2018.10.013",

language = "English",

volume = "73",

pages = "48--60.e5",

journal = "Molecular cell",

issn = "1097-2765",

number = "1",

}

TY - JOUR

T1 - A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

AU - Barajas-Mora, E. Mauricio

AU - Kleiman, Eden

AU - Xu, Jeffrey

AU - Carrico, Nancy C.

AU - Lu, Hanbin

AU - Oltz, Eugene M.

AU - Murre, Cornelis

AU - Feeney, Ann J.

PY - 2019/1/3

Y1 - 2019/1/3

N2 - Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.

AB - Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.

KW - 3D structure

KW - B cells

KW - Igκ

KW - V(D)J recombination

KW - antibody repertoire

KW - chromatin conformation capture

KW - enhancer

KW - long-range chromatin interactions

KW - nuclear topology

KW - subTAD

UR - https://www.scopus.com/pages/publications/85059499828

U2 - 10.1016/j.molcel.2018.10.013

DO - 10.1016/j.molcel.2018.10.013

M3 - Article

C2 - 30449725

AN - SCOPUS:85059499828

SN - 1097-2765

VL - 73

SP - 48-60.e5

JO - Molecular cell

JF - Molecular cell

IS - 1

ER -

A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this