A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

E. Mauricio Barajas-Mora, Eden Kleiman, Jeffrey Xu, Nancy C. Carrico, Hanbin Lu, Eugene M. Oltz, Cornelis Murre, Ann J. Feeney

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.

Original languageEnglish
Pages (from-to)48-60.e5
JournalMolecular cell
Volume73
Issue number1
DOIs
StatePublished - Jan 3 2019

Keywords

  • 3D structure
  • B cells
  • Igκ
  • V(D)J recombination
  • antibody repertoire
  • chromatin conformation capture
  • enhancer
  • long-range chromatin interactions
  • nuclear topology
  • subTAD

Fingerprint Dive into the research topics of 'A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire'. Together they form a unique fingerprint.

Cite this