A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

E. Mauricio Barajas-Mora; Eden Kleiman; Jeffrey Xu; Nancy C. Carrico; Hanbin Lu; Eugene M. Oltz; Cornelis Murre; Ann J. Feeney

doi:10.1016/j.molcel.2018.10.013

A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

E. Mauricio Barajas-Mora, Eden Kleiman, Jeffrey Xu, Nancy C. Carrico, Hanbin Lu, Eugene M. Oltz, Cornelis Murre, Ann J. Feeney

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.

Original language	English
Pages (from-to)	48-60.e5
Journal	Molecular cell
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2018.10.013
State	Published - Jan 3 2019

Keywords

3D structure
B cells
Igκ
V(D)J recombination
antibody repertoire
chromatin conformation capture
enhancer
long-range chromatin interactions
nuclear topology
subTAD

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10.1016/j.molcel.2018.10.013

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title = "A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire",

abstract = "Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.",

keywords = "3D structure, B cells, Igκ, V(D)J recombination, antibody repertoire, chromatin conformation capture, enhancer, long-range chromatin interactions, nuclear topology, subTAD",

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AU - Barajas-Mora, E. Mauricio

AU - Kleiman, Eden

AU - Xu, Jeffrey

AU - Carrico, Nancy C.

AU - Lu, Hanbin

AU - Oltz, Eugene M.

AU - Murre, Cornelis

AU - Feeney, Ann J.

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AB - Barajas-Mora et al. demonstrate that an enhancer—E88—in the V gene region of the Igκ locus regulates long-range chromatin interactions, shaping its 3D structure, enabling different V-gene-containing subTADs to come in proximity to the J genes to generate a diverse repertoire. Consequently, E88 deletion perturbs the resulting B cell repertoire.

KW - 3D structure

KW - B cells

KW - Igκ

KW - V(D)J recombination

KW - antibody repertoire

KW - chromatin conformation capture

KW - enhancer

KW - long-range chromatin interactions

KW - nuclear topology

KW - subTAD

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AN - SCOPUS:85059499828

SN - 1097-2765

VL - 73

SP - 48-60.e5

JO - Molecular cell

JF - Molecular cell

IS - 1

ER -

A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

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Keywords

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