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• 2024

  Ultra-Efficient Edge Cardiac Disease Detection Towards Real-Time Precision Health

  Wong, J., Nerbonne, J. & Zhang, Q., 2024, In: IEEE Access. 12, p. 9940-9951 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Scopus citations
• 2023

  Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (Na_V) channels in mouse

  Lesage, A., Lorenzini, M., Burel, S., Sarlandie, M., Bibault, F., Lindskog, C., Maloney, D., Silva, J. R., Townsend, R. R., Nerbonne, J. M. & Marionneau, C., Sep 4 2023, In: Journal of General Physiology. 155, 9, e202213293.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors

  Angsutararux, P., Dutta, A. K., Marras, M., Abella, C., Mellor, R. L., Shi, J., Nerbonne, J. M. & Silva, J. R., May 1 2023, In: Journal of General Physiology. 155, 5, e202213300.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• Effects of NALCN-Encoded Na1 Leak Currents on the Repetitive Firing Properties of SCN Neurons Depend on K+ Driven Rhythmic Changes in Input Resistance

  Yang, N. D., Mellor, R. L., Hermanstyne, T. O. & Nerbonne, J. M., Jul 12 2023, In: Journal of Neuroscience. 43, 28, p. 5132-5141 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Scopus citations

• Kv12-encoded K⁺ channels drive the day–night switch in the repetitive firing rates of SCN neurons

  Hermanstyne, T. O., Yang, N. D., Granados-Fuentes, D., Li, X., Mellor, R. L., Jegla, T., Herzog, E. D. & Nerbonne, J. M., Sep 4 2023, In: Journal of General Physiology. 155, 9, e202213310.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Scopus citations

• Patch-Clamp Recordings from Native Cells and Isolation of Membrane Currents

  Nerbonne, J. M., Jan 1 2023, Textbook of Ion Channels Volume I: Basics and Methods. CRC Press, Vol. 1. p. 155-171 17 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
• 2022

  Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine

  Yang, N. D., Kanyo, R., Zhao, L., Li, J., Kang, P. W., Dou, A. K., White, K. M. F., Shi, J., Nerbonne, J. M., Kurata, H. T. & Cui, J., Jul 2022, In: Science Advances. 8, 29, eabo3625.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Scopus citations

• Integrated multi-omic characterization of congenital heart disease

  Hill, M. C., Kadow, Z. A., Long, H., Morikawa, Y., Martin, T. J., Birks, E. J., Campbell, K. S., Nerbonne, J., Lavine, K., Wadhwa, L., Wang, J., Turaga, D., Adachi, I. & Martin, J. F., Aug 4 2022, In: Nature. 608, 7921, p. 181-191 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  45 Scopus citations

• Intrinsic Mechanisms in the Gating of Resurgent Na⁺ Currents

  Ransdell, J., Moreno, J., Bhagavan, D., Silva, J. R. & Nerbonne, J. M., Jan 2022, In: eLife. 11, e70173.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Scopus citations
• 2021

  Controlling the Traffic to Keep the Beat: Targeting of Myocardial Sodium Channels

  Nerbonne, J. M., Jul 23 2021, In: Circulation research. 129, 3, p. 366-368 3 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  1 Scopus citations

• Identification of structures for ion channel kinetic models

  Mangold, K. E., Wang, W., Johnson, E. K., Bhagavan, D., Moreno, J. D., Nerbonne, J. M. & Silva, J. R., Aug 2021, In: PLoS computational biology. 17, 8, e1008932.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Scopus citations

• Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin t drives cellular adaptation

  Clippinger, S. R., Cloonan, P. E., Wang, W., Greenberg, L., Stump, W. T., Angsutararux, P., Nerbonne, J. M. & Greenberg, M. J., May 3 2021, In: Journal of General Physiology. 153, 5, e202012787.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  14 Scopus citations

• Modulation of the effects of class Ib antiarrhythmics on cardiac Na_V1.5-encoded channels by accessory Na_Vβ subunits

  Zhu, W., Wang, W., Angsutararux, P., Mellor, R. L., Isom, L. L., Nerbonne, J. M. & Silva, J. R., Aug 9 2021, In: JCI Insight. 6, 15, e143092.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  10 Scopus citations

• Molecular, cellular and functional changes in the retinas of young adult mice lacking the voltage-gated K⁺ channel subunits Kv8.2 and K2.1

  Jiang, X., Rashwan, R., Voigt, V., Nerbonne, J., Hunt, D. M. & Carvalho, L. S., May 1 2021, In: International journal of molecular sciences. 22, 9, 4877.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Scopus citations

• Proteomic and functional mapping of cardiac Na_V1.5 channel phosphorylation sites

  Lorenzini, M., Burel, S., Lesage, A., Wagner, E., Charriere, C., Chevillard, P. M., Evrard, B., Maloney, D., Ruff, K. M., Pappu, R. V., Wagner, S., Nerbonne, J. M., Silva, J. R., Townsend, R. R., Maier, L. S. & Marionneau, C., 2021, In: Journal of General Physiology. 153, 2, e202012646.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Scopus citations

• Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations

  Delisle, B. P., George, A. L., Nerbonne, J. M., Bass, J. T., Ripplinger, C. M., Jain, M. K., Hermanstyne, T. O., Young, M. E., Kannankeril, P. J., Duffy, J. F., Goldhaber, J. I., Hall, M. H., Somers, V. K., Smolensky, M. H., Garnett, C. E., Anafi, R. C., Scheer, F. A. J. L., Shivkumar, K., Shea, S. A. & Balijepalli, R. C., Nov 1 2021, In: Circulation: Arrhythmia and Electrophysiology. 14, 11, p. E010190

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  5 Scopus citations

• Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects

  Delisle, B. P., George, A. L., Nerbonne, J. M., Bass, J. T., Ripplinger, C. M., Jain, M. K., Hermanstyne, T. O., Young, M. E., Kannankeril, P. J., Duffy, J. F., Goldhaber, J. I., Hall, M. H., Somers, V. K., Smolensky, M. H., Garnett, C. E., Anafi, R. C., Scheer, F. A. J. L., Shivkumar, K., Shea, S. A. & Balijepalli, R. C., Nov 1 2021, In: Circulation: Arrhythmia and Electrophysiology. 14, 11, p. E010181

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  9 Scopus citations
• 2020

  Polycystin 2 is increased in disease to protect against stress-induced cell death

  Brill, A. L., Fischer, T. T., Walters, J. M., Marlier, A., Sewanan, L. R., Wilson, P. C., Johnson, E. K., Moeckel, G., Cantley, L. G., Campbell, S. G., Nerbonne, J. M., Chung, H. J., Robert, M. E. & Ehrlich, B. E., Dec 1 2020, In: Scientific reports. 10, 1, 386.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  14 Scopus citations
• 2019

  Circulating long noncoding RNA DKFZP434I0714 predicts adverse cardiovascular outcomes in patients with end-stage renal disease

  Lai, C. F., Chen, Y. T., Gu, J., Nerbonne, J. M., Lin, C. H. & Yang, K. C., Feb 15 2019, In: International Journal of Cardiology. 277, p. 212-219 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  20 Scopus citations

• Regional differences in the expression of tetrodotoxin-sensitive inward Ca²⁺ and outward Cs⁺/K⁺ currents in mouse and human ventricles

  Wang, W., Mellor, R. L., Nerbonne, J. M. & Balke, C. W., Jan 1 2019, In: Channels. 13, 1, p. 72-87 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• The role of the voltage-gated potassium channel proteins Kv8.2 and Kv2.1 in vision and retinal disease: Insights from the study of mouse gene knock-out mutations

  Hart, N. S., Mountford, J. K., Voigt, V., Fuller-Carter, P., Barth, M., Nerbonne, J. M., Hunt, D. M. & Carvalho, L. S., Jan 1 2019, In: eNeuro. 6, 1, e0032-19.2019.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  16 Scopus citations
• 2018

  Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles

  Johnson, E. K., Springer, S. J., Wang, W., Dranoff, E. J., Zhang, Y., Kanter, E. M., Yamada, K. A. & Nerbonne, J. M., Jan 1 2018, In: Circulation: Arrhythmia and Electrophysiology. 11, 1, e005914.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  32 Scopus citations

• Endoplasmic reticulum protein TxNDC5 augments myocardial fibrosis by facilitating extracellular matrix protein folding and redox-sensitive cardiac fibroblast activation

  Shih, Y. C., Chen, C. L., Zhang, Y., Mellor, R. L., Kanter, E. M., Fang, Y., Wang, H. C., Hung, C. T., Nong, J. Y., Chen, H. J., Lee, T. H., Tseng, Y. S., Chen, C. N., Wu, C. C., Lin, S. L., Yamada, K. A., Nerbonne, J. M. & Yang, K. C., 2018, In: Circulation research. 122, 8, p. 1052-1068 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  70 Scopus citations

• Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles

  Johnson, E. K., Matkovich, S. J. & Nerbonne, J. M., Dec 1 2018, In: Scientific reports. 8, 1, 13919.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  28 Scopus citations

• Voltage-gated sodium currents in cerebellar Purkinje neurons: functional and molecular diversity

  Ransdell, J. L. & Nerbonne, J. M., Oct 1 2018, In: Cellular and Molecular Life Sciences. 75, 19, p. 3495-3505 11 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  8 Scopus citations
• 2017

  Acute knockdown of Kv4.1 regulates repetitive firing rates and clock gene expression in the suprachiasmatic nucleus and daily rhythms in locomotor behavior

  Hermanstyne, T. O., Granados-Fuentes, D., Mellor, R. L., Herzog, E. D. & Nerbonne, J. M., 2017, In: eNeuro. 4, 3, e0377-16.2017.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  22 Scopus citations

• C-terminal phosphorylation of Na_V1.5 impairs FGF13-dependent regulation of channel inactivation

  Burel, S., Coyan, F. C., Lorenzini, M., Meyer, M. R., Lichti, C. F., Brown, J. H., Loussouarn, G., Charpentier, F., Nerbonne, J. M., Townsend, R. R., Maier, L. S. & Marionneau, C., Oct 20 2017, In: Journal of Biological Chemistry. 292, 42, p. 17431-17448 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  23 Scopus citations

• Early remodeling of repolarizing K⁺ currents in the αMHC^403/+ mouse model of familial hypertrophic cardiomyopathy

  Hueneke, R., Adenwala, A., Mellor, R. L., Seidman, J. G., Seidman, C. E. & Nerbonne, J. M., Feb 1 2017, In: Journal of Molecular and Cellular Cardiology. 103, p. 93-101 9 p.

  Research output: Contribution to journal › Article › peer-review
  5 Scopus citations

• Erratum: Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance (Cell Reports (2017) 19(3) (532–544) (S2211124717304291) (10.1016/j.celrep.2017.03.068))

  Ransdell, J. L., Dranoff, E., Lau, B., Lo, W. L., Donermeyer, D. L., Allen, P. M. & Nerbonne, J. M., Aug 8 2017, In: Cell Reports. 20, 6, p. 1502 1 p.

  Research output: Contribution to journal › Comment/debate

  Open Access
  3 Scopus citations

• Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance

  Ransdell, J. L., Dranoff, E., Lau, B., Lo, W. L., Donermeyer, D. L., Allen, P. M. & Nerbonne, J. M., Apr 18 2017, In: Cell Reports. 19, 3, p. 532-544 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  23 Scopus citations

• Mechanisms of noncovalent β subunit regulation of Na_V channel gating

  Zhu, W., Voelker, T. L., Varga, Z., Schubert, A. R., Nerbonne, J. M. & Silva, J. R., Aug 1 2017, In: Journal of General Physiology. 149, 8, p. 813-831 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  53 Scopus citations

• Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

  Chiamvimonvat, N., Chen-Izu, Y., Clancy, C. E., Deschenes, I., Dobrev, D., Heijman, J., Izu, L., Qu, Z., Ripplinger, C. M., Vandenberg, J. I., Weiss, J. N., Koren, G., Banyasz, T., Grandi, E., Sanguinetti, M. C., Bers, D. M. & Nerbonne, J. M., Apr 1 2017, In: Journal of Physiology. 595, 7, p. 2229-2252 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  80 Scopus citations

• THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

  CGTP Collaborators, Dec 2017, In: British Journal of Pharmacology. 174, p. S1-S16

  Research output: Contribution to journal › Article › peer-review

  Open Access
  228 Scopus citations
• 2016

  Cardiac Mechano-Gated Ion Channels and Arrhythmias

  Peyronnet, R., Nerbonne, J. M. & Kohl, P., Jan 22 2016, In: Circulation research. 118, 2, p. 311-329 19 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  153 Scopus citations

• Distinct Firing Properties of Vasoactive Intestinal Peptide-Expressing Neurons in the Suprachiasmatic Nucleus

  Hermanstyne, T. O., Simms, C. L., Carrasquillo, Y., Herzog, E. D. & Nerbonne, J. M., Feb 1 2016, In: Journal of Biological Rhythms. 31, 1, p. 57-67 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  26 Scopus citations

• Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling

  Yang, K. C. & Nerbonne, J. M., Apr 1 2016, In: Trends in Cardiovascular Medicine. 26, 3, p. 209-218 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  42 Scopus citations

• Molecular Basis of Functional Myocardial Potassium Channel Diversity

  Nerbonne, J. M., Jun 1 2016, In: Cardiac Electrophysiology Clinics. 8, 2, p. 257-273 17 p.

  Research output: Contribution to journal › Review article › peer-review
  32 Scopus citations

• Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents

  Khandekar, A., Springer, S., Wang, W., Hicks, S., Weinheimer, C., Diaz-Trelles, R., Nerbonne, J. M. & Rentschler, S., Dec 9 2016, In: Circulation research. 119, 12, p. 1324-1338 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  31 Scopus citations

• Proteomic analysis of native cerebellar iFGF14 complexes

  Bosch, M. K., Nerbonne, J. M., Townsend, R. R., Miyazaki, H., Nukina, N., Ornitz, D. M. & Marionneau, C., Jul 3 2016, In: Channels. 10, 4, p. 297-312 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Scopus citations

• Training the Next Generation of Translational Cardiovascular Investigators: Is the Pipeline Half Full or Half Empty?

  Nerbonne, J. M. & Mann, D. L., Oct 1 2016, In: JACC: Basic to Translational Science. 1, 6, p. 554-556 3 p.

  Research output: Contribution to journal › Editorial

  Open Access
  1 Scopus citations
• 2015

  I_A channels encoded by Kv1.4 and Kv4.2 regulate circadian period of Per2 expression in the suprachiasmatic nucleus

  Granados-Fuentes, D., Hermanstyne, T. O., Carrasquillo, Y., Nerbonne, J. M. & Herzog, E. D., Oct 2015, In: Journal of Biological Rhythms. 30, 5, p. 396-407 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  19 Scopus citations

• Intracellular FGF14 (iFGF14) is required for spontaneous and evoked firing in cerebellar Purkinje neurons and for motor coordination and balance

  Bosch, M. K., Carrasquillo, Y., Ransdell, J. L., Kanakamedala, A., Ornitz, D. M. & Nerbonne, J. M., Apr 29 2015, In: Journal of Neuroscience. 35, 17, p. 6752-6769 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  54 Scopus citations

• The Concise Guide to PHARMACOLOGY 2015/16: Overview

  CGTP Collaborators, Dec 1 2015, In: British Journal of Pharmacology. 172, 24, p. 5729-5743 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  173 Scopus citations
• 2014

  Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome

  Boczek, N. J., Ye, D., Johnson, E. K., Wang, W., Crotti, L., Tester, D. J., Dagradi, F., Mizusawa, Y., Torchio, M., Alders, M., Giudicessi, J. R., Wilde, A. A. M., Schwartz, P. J., Nerbonne, J. M. & Ackerman, M. J., Aug 1 2014, In: Circulation research. 115, 4, p. 460-469 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  48 Scopus citations

• Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support

  Yang, K. C., Yamada, K. A., Patel, A. Y., Topkara, V. K., George, I., Cheema, F. H., Ewald, G. A., Mann, D. L. & Nerbonne, J. M., Mar 4 2014, In: Circulation. 129, 9, p. 1009-1021 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  355 Scopus citations

• Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

  Speca, D. J., Ogata, G., Mandikian, D., Bishop, H. I., Wiler, S. W., Eum, K., Wenzel, H. J., Doisy, E. T., Matt, L., Campi, K. L., Golub, M. S., Nerbonne, J. M., Hell, J. W., Trainor, B. C., Sack, J. T., Schwartzkroin, P. A. & Trimmer, J. S., Apr 2014, In: Genes, Brain and Behavior. 13, 4, p. 394-408 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  89 Scopus citations

• Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo

  Bosch, M. K., Nerbonne, J. M. & Ornitz, D. M., Aug 5 2014, In: PloS one. 9, 8, e104062.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Scopus citations

• Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

  Victor, M. B., Richner, M., Hermanstyne, T. O., Ransdell, J. L., Sobieski, C., Deng, P. Y., Klyachko, V. A., Nerbonne, J. M. & Yoo, A. S., Oct 22 2014, In: Neuron. 84, 2, p. 311-323 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  242 Scopus citations

• IA channels: Diverse regulatory mechanisms

  Carrasquillo, Y. & Nerbonne, J. M., Apr 2014, In: Neuroscientist. 20, 2, p. 104-111 8 p.

  Research output: Contribution to journal › Article › peer-review
  35 Scopus citations

• Mouse models of arrhythmogenic cardiovascular disease: Challenges and opportunities

  Nerbonne, J. M., Apr 2014, In: Current Opinion in Pharmacology. 15, 1, p. 107-114 8 p.

  Research output: Contribution to journal › Review article › peer-review
  29 Scopus citations