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• Blood brain barrier permeability of ¹¹C labeled alcohols and ¹⁵O labeled water

  Raichle, M. E., Eichling, J. O., Straatmann, M. G., Welch, M. J., Larson, K. B. & Ter-Pogossian, M. M., 1976, In: Unknown Journal. 230, 2, p. 543-552 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  178 Scopus citations

• Blood–brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication

  Chien, C. Y., Xu, L., Pacia, C. P., Yue, Y. & Chen, H., Dec 2022, In: Scientific reports. 12, 1, 16147.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Blood-brain barrier disruption and perivascular beta-amyloid accumulation in the brain of aged rats with spontaneous hypertension: Evaluation with dynamic contrast-enhanced magnetic resonance imaging

  Wang, Y., Zhang, R., Tao, C., Xu, Z., Chen, W., Wang, C., Song, L., Zheng, J. & Gao, F., May 1 2018, In: Korean Journal of Radiology. 19, 3, p. 498-507 10 p.

  Research output: Contribution to journal › Article › peer-review
  13 Scopus citations

• Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

  Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D’Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Chui, H. C., Law, M., Toga, A. W. & Zlokovic, B. V., Feb 1 2019, In: Nature medicine. 25, 2, p. 270-276 7 p.

  Research output: Contribution to journal › Article › peer-review
  615 Scopus citations

• Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein e isoform-specific mechanism

  Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M. & Zlokovic, B. V., Oct 19 2018, In: Molecular neurodegeneration. 13, 1, 57.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  115 Scopus citations

• Blood Biomarkers from Research Use to Clinical Practice: What Must Be Done? A Report from the EU/US CTAD Task Force

  EU/US/CTAD Task Force, Oct 2022, In: The journal of prevention of Alzheimer's disease. 9, 4, p. 569-579 11 p.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations

• Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

  Dekosky, S. T., Kochanek, P. M., Valadka, A. B., Clark, R. S. B., Chou, S. H. Y., Au, A. K., Horvat, C., Jha, R. M., Mannix, R., Wisniewski, S. R., Wintermark, M., Rowell, S. E., Welch, R. D., Lewis, L., House, S., Tanzi, R. E., Smith, D. R., Vittor, A. Y., Denslow, N. D., Davis, M. D., & 2 othersGlushakova, O. Y. & Hayes, R. L., Jan 1 2021, In: Journal of neurotrauma. 38, 1, p. 1-43 43 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  33 Scopus citations

• Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis

  Medeiros, G. C., Gould, T. D., Prueitt, W. L., Nanavati, J., Grunebaum, M. F., Farber, N. B., Singh, B., Selvaraj, S., Machado-Vieira, R., Achtyes, E. D., Parikh, S. V., Frye, M. A., Zarate, C. A. & Goes, F. S., Sep 2022, In: Molecular Psychiatry. 27, 9, p. 3658-3669 12 p.

  Research output: Contribution to journal › Review article › peer-review
  3 Scopus citations

• Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer

  Judge, S. J., Yanagisawa, M., Sturgill, I. R., Bateni, S. B., Gingrich, A. A., Foltz, J. A., Lee, D. A., Modiano, J. F., Monjazeb, A. M., Culp, W. T. N., Rebhun, R. B., Murphy, W. J., Kent, M. S. & Canter, R. J., Feb 1 2020, In: PloS one. 15, 2, e0224775.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  12 Scopus citations

• Blood (1→3)-β-D-glucan as a diagnostic test for HIV-related pneumocystis jirovecii pneumonia

  Sax, P. E., Komarow, L., Finkelman, M. A., Grant, P. M., Andersen, J., Scully, E., Powderly, W. G. & Zolopa, A. R., Jul 15 2011, In: Clinical Infectious Diseases. 53, 2, p. 197-202 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  94 Scopus citations

• Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines

  Pearson, W. L. & Nichols, C. G., Sep 1998, In: Journal of General Physiology. 112, 3, p. 351-363 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  45 Scopus citations

• Block of outward rectifier DRK1 potassium channels, expressed in Xenopus oocytes, by Mg²⁺

  Lopatin, A. N. & Nichols, C. G., Dec 1 1993, In: Journal of Physiology. 473, p. 45P

  Research output: Contribution to journal › Article › peer-review

• Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: Selective binding to open channels

  Huettner, J. E. & Bean, B. P., 1988, In: Proceedings of the National Academy of Sciences of the United States of America. 85, 4, p. 1307-1311 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  654 Scopus citations

• Block of mouse Slo1 and Slo3 K⁺ channels by CTX, IbTX, TEA, 4-AP and quinidine

  Tang, Q. Y., Zhang, Z., Xia, O. M. & Lingle, C. J., 2010, In: Channels. 4, 1, p. 1-20 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  40 Scopus citations

• Block of K _v1.7 potassium currents increases glucose-stimulated insulin secretion

  Finol-Urdaneta, R. K., Remedi, M. S., Raasch, W., Becker, S., Clark, R. B., Strüver, N., Pavlov, E., Nichols, C. G., French, R. J. & Terlau, H., May 2012, In: EMBO Molecular Medicine. 4, 5, p. 424-434 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  27 Scopus citations

• Block of glutamatergic excitatory synaptic channels by chlorisondamine

  Lingle, C., Eisen, J. S. & Marder, E., Jan 1 1981, In: Molecular pharmacology. 19, 2, p. 349-353 5 p.

  Research output: Contribution to journal › Article › peer-review

  18 Scopus citations

• Block of delayed rectifier (DRK1) K+ channels by internal 2, 3-butanedione monoxime in Xenopus oocytes

  Lopatin, A. N. & Nichols, C. G., 1993, In: Receptors and Channels. 1, 4, p. 279-286 8 p.

  Research output: Contribution to journal › Article › peer-review

  6 Scopus citations

• Block of an ether-a-go-go-like K⁺ channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans

  Weinshenker, D., Wei, A., Salkoff, L. & Thomas, J. H., Nov 15 1999, In: Journal of Neuroscience. 19, 22, p. 9831-9840 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  56 Scopus citations

• Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis

  Piggott, K., Deng, J., Warrington, K., Younge, B., Kubo, J. T., Desai, M., Goronzy, J. J. & Weyand, C. M., Jan 25 2011, In: Circulation. 123, 3, p. 309-318 10 p.

  Research output: Contribution to journal › Article › peer-review
  110 Scopus citations

• Blocking the interleukin 2 (IL2)-induced systemic autophagic syndrome promotes profound antitumor effects and limits toxicity

  Lotze, M. T., Buchser, W. J. & Liang, X., Aug 2012, In: Autophagy. 8, 8, p. 1264-1266 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  Open Access
  24 Scopus citations

• Blocking the interaction between apolipoprotein e and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration

  Kuszczyk, M. A., Sanchez, S., Pankiewicz, J., Kim, J., Duszczyk, M., Guridi, M., Asuni, A. A., Sullivan, P. M., Holtzman, D. M. & Sadowski, M. J., May 2013, In: American Journal of Pathology. 182, 5, p. 1750-1768 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  65 Scopus citations

• Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes

  Nakano, M., Mann, D. L. & Knowlton, A. A., 1997, In: Circulation. 95, 6, p. 1523-1531 9 p.

  Research output: Contribution to journal › Article › peer-review
  105 Scopus citations

• Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain

  Chatterjee, S., Bish, L. T., Jayasankar, V., Stewart, A. S., Woo, Y. J., Crow, M. T., Gardner, T. J., Sweeney, H. L., Patterson, G. A., Caldarone, C. A. & Damiano, R. J., Jun 1 2003, In: Journal of Thoracic and Cardiovascular Surgery. 125, 6, p. 1461-1469 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  40 Scopus citations

• Blocking the BK_Cachannel induces NF-κB nuclear translocation by increasing nuclear calcium concentration

  Kent, L. N., Li, Y., Wakle-Prabagaran, M., Naqvi, M. Z., Weil, S. G. & England, S. K., Mar 1 2022, In: Biology of reproduction. 106, 3, p. 441-448 8 p.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations

• Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice

  Pankiewicz, J. E., Guridi, M., Kim, J., Asuni, A. A., Sanchez, S., Sullivan, P. M., Holtzman, D. M. & Sadowski, M. J., Jan 27 2014, In: Acta Neuropathologica Communications. 2, 1, 75.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  44 Scopus citations

• Blocking TGF-β and -β-catenin epithelial crosstalk exacerbates CKD

  Nlandu-Khodo, S., Neelisetty, S., Phillips, M., Manolopoulou, M., Bhave, G., May, L., Clark, P. E., Yang, H., Fogo, A. B., Harris, R. C., Taketo, M. M., Lee, E. & Gewin, L. S., Dec 2017, In: Journal of the American Society of Nephrology. 28, 12, p. 3490-3503 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  41 Scopus citations

• Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

  Toth, J. I., Yang, S. H., Qiao, X., Beigneux, A. P., Gelb, M. H., Moulson, C. L., Miner, J. H., Young, S. G. & Fong, L. G., Sep 6 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 36, p. 12873-12878 6 p.

  Research output: Contribution to journal › Article › peer-review
  227 Scopus citations

• Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

  Pinho-Ribeiro, F. A., Baddal, B., Haarsma, R., O'Seaghdha, M., Yang, N. J., Blake, K. J., Portley, M., Verri, W. A., Dale, J. B., Wessels, M. R. & Chiu, I. M., May 17 2018, In: Cell. 173, 5, p. 1083-1097.e22

  Research output: Contribution to journal › Article › peer-review

  Open Access
  186 Scopus citations

• Blocking monoclonal antibodies specific for mouse IFN-α/β receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection

  Sheehan, K. C. F., Lai, K. S., Dunn, G. P., Bruce, A. T., Diamond, M. S., Heutel, J. D., Dungo-Arthur, C., Carrero, J. A., White, J. M., Hertzog, P. J. & Schreiber, R. D., Nov 2006, In: Journal of Interferon and Cytokine Research. 26, 11, p. 804-819 16 p.

  Research output: Contribution to journal › Article › peer-review
  194 Scopus citations

• Blocking IL-6 signaling deates pulmonary arterial hypertension

  Lavine, K., May 23 2018, In: Science translational medicine. 10, 442, eaat8534.

  Research output: Contribution to journal › Comment/debate
  1 Scopus citations

• Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo

  Yang, L., Jackson, E., Woerner, B. M., Perry, A., Piwnica-Worms, D. & Rubin, J. B., Jan 15 2007, In: Cancer research. 67, 2, p. 651-658 8 p.

  Research output: Contribution to journal › Article › peer-review
  131 Scopus citations

• Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome

  Park, S. J., Kim, Y., Li, C., Suh, J., Sivapackiam, J., Goncalves, T. M., Jarad, G., Zhao, G., Urano, F., Sharma, V. & Chen, Y. M., Aug 30 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 35, e2116505119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Blocking cell cycle progression through CDK4/6 protects against chronic kidney disease

  Osaki, Y., Manolopoulou, M., Ivanova, A. V., Vartanian, N., Mignemi, M. P., Kern, J., Chen, J., Yang, H., Fogo, A. B., Zhang, M., Robinson-Cohen, C. & Gewin, L. S., Jun 22 2022, In: JCI Insight. 7, 12, e158754.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Scopus citations

• Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals

  Tyner, J. W., Kim, E. Y., Ide, K., Pelletier, M. R., Roswit, W. T., Morton, J. D., Battaile, J. T., Patel, A. C., Patterson, G. A., Castro, M., Spoor, M. S., You, Y., Brody, S. L. & Holtzman, M. J., Feb 1 2006, In: Journal of Clinical Investigation. 116, 2, p. 309-321 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  206 Scopus citations

• Blocker protection by short spermine analogs: Refined mapping of the spermine binding site in a Kir channel

  Kurata, H. T., Diraviyam, K., Marton, L. J. & Nichols, C. G., Oct 15 2008, In: Biophysical Journal. 95, 8, p. 3827-3839 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  15 Scopus citations

• Blockage of CD59 function restores activities of neutralizing and nonneutralizing antibodies in triggering antibody-dependent complement-mediated lysis of HIV-1 virions and provirus-activated latently infected cells

  Yang, K., Lan, J., Shepherd, N., Hu, N., Xing, Y., Byrd, D., Amet, T., Jewell, C., Gupta, S., Kounga, C., Gao, J. & Yu, Q., 2015, In: Journal of virology. 89, 18, p. 9393-9406 14 p.

  Research output: Contribution to journal › Article › peer-review
  11 Scopus citations

• Blockade of virus infection by human CD4⁺ T cells via a cytokine relay network

  Davis, A. M., Hagan, K. A., Matthews, L. A., Bajwa, G., Gill, M. A., Gale, M. & Farrar, J. D., 2008, In: Journal of Immunology. 180, 10, p. 6923-6932 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  16 Scopus citations

• Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis

  Piccio, L., Buonsanti, C., Mariani, M., Cella, M., Gilfillan, S., Cross, A. H., Colonna, M. & Panina-Bordignon, P., May 2007, In: European Journal of Immunology. 37, 5, p. 1290-1301 12 p.

  Research output: Contribution to journal › Article › peer-review
  196 Scopus citations

• Blockade ofthe negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis

  Chang, K. C., Burnham, C. A., Compton, S. M., Rasche, D. P., Mazuski, R. J., SMcDonough, J., Unsinger, J., Korman, A. J., Green, J. M. & Hotchkiss, R. S., May 11 2013, In: Critical Care. 17, 3, R85.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  187 Scopus citations

• Blockade of phosphodiesterase Type 5 enhances rat neurohypophysial excitability and electrically evoked oxytocin release

  Zhang, Z., Klyachko, V. & Jackson, M. B., Oct 1 2007, In: Journal of Physiology. 584, 1, p. 137-147 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  18 Scopus citations

• Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain

  Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L. & Olney, J. W., Jan 1 1999, In: Science. 283, 5398, p. 70-74 5 p.

  Research output: Contribution to journal › Article › peer-review
  1702 Scopus citations

• Blockade of JNK and NFAT pathways attenuates orthopedic particle-stimulated osteoclastogenesis of human osteoclast precursors and murine calvarial osteolysis

  Yamanaka, Y., Clohisy, J. C. F., Ito, H., Matsuno, T. & Abu-Amer, Y., Jan 2013, In: Journal of Orthopaedic Research. 31, 1, p. 67-72 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  23 Scopus citations

• Blockade of ionotropic quisqualate receptor desensitization in rat hippocampal neurons by wheatgerm agglutinin and other lectins

  Thio, L. L., Clifford, D. B. & Zorumski, C. F., Jan 1993, In: Neuroscience. 52, 1, p. 35-44 10 p.

  Research output: Contribution to journal › Article › peer-review
  12 Scopus citations

• Blockade of ionotropic quisqualate receptor desensitization by wheat germ agglutinin in cultured postnatal rat hippocampal neurons

  Liu Lin Thio, L. T., Clifford, D. B. & Zorumski, C. F., 1992, In: Journal of neurophysiology. 68, 6, p. 1917-1929 13 p.

  Research output: Contribution to journal › Article › peer-review
  8 Scopus citations

• Blockade of interferon beta, but not interferon alpha, signaling controls persistent viral infection

  Ng, C. T., Sullivan, B. M., Teijaro, J. R., Lee, A. M., Welch, M., Rice, S., Sheehan, K. C. F., Schreiber, R. D. & Oldstone, M. B. A., May 13 2015, In: Cell Host and Microbe. 17, 5, p. 653-661 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  118 Scopus citations

• Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema

  Miller, R. L., Denny, G. O., Knuepfer, M. M., Kleyman, T. R., Jackson, E. K., Salkoff, L. B. & Loewy, A. D., Mar 19 2015, In: Brain Research. 1601, p. 40-51 12 p., 44015.

  Research output: Contribution to journal › Article › peer-review
  2 Scopus citations

• Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons

  Zorumski, C. F., Thio, L. L., Clark, G. D. & Clifford, D. B., Jul 1990, In: Neuron. 5, 1, p. 61-66 6 p.

  Research output: Contribution to journal › Article › peer-review
  59 Scopus citations

• Blockade of cholinergic channels by chlorisondamine on a crustacean muscle.

  Lingle, C., Jun 1 1983, In: The Journal of Physiology. 339, 1, p. 395-417 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  43 Scopus citations

• Blockade of CD28/B7 interaction prevents epitope spreading and clinical relapses of murine relapsing EAE

  Miller, S. D., Vanderluat, C. L., Karandikar, N. J., Pope, J. G., Lenschow, D. J., Pal Canto, M. C. & Bluestone, J. A., Dec 1 1996, In: FASEB Journal. 10, 6, p. A1160

  Research output: Contribution to journal › Article › peer-review

• Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

  Miller, S. D., Vanderlugt, C. L., Lenschow, D. J., Pope, J. G., Karandikar, N. J., Dal Canto, M. C. & Bluestone, J. A., Dec 1995, In: Immunity. 3, 6, p. 739-745 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  305 Scopus citations