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• TBX6 null variants and a common hypomorphic allele in congenital scoliosis

  Wu, N., Ming, X., Xiao, J., Wu, Z., Chen, X., Shinawi, M., Shen, Y., Yu, G., Liu, J., Xie, H., Gucev, Z. S., Liu, S., Yang, N., Al-Kateb, H., Chen, J., Zhang, J., Hauser, N., Zhang, T., Tasic, V., Liu, P., & 38 othersSu, X., Pan, X., Liu, C., Wang, L., Shen, J., Shen, J., Chen, Y., Zhang, T., Zhang, J., Choy, K. W., Wang, J., Wang, Q., Li, S., Zhou, W., Guo, J., Wang, Y., Zhang, C., Zhao, H., An, Y., Zhao, Y., Wang, J., Liu, Z., Zuo, Y., Tian, Y., Weng, X., Sutton, V. R., Wang, H., Ming, Y., Kulkarni, S., Zhong, T. P., Giampietro, P. F., Dunwoodie, S. L., Cheung, S. W., Zhang, X., Jin, L., Lupski, J. R., Qiu, G. & Zhang, F., Jan 22 2015, In: New England Journal of Medicine. 372, 4, p. 341-350 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  184 Scopus citations

• TC10 is regulated by Caveolin in 3T3-L1 Adipocytes

  Bridges, D., Chang, L., Lodhi, I. J., Clark, N. A. & Saltiel, A. R., Aug 10 2012, In: PloS one. 7, 8, e42451.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Scopus citations

• Tc-99m-DTPA aerosol and radioactive gases compared as adjuncts to perfusion scintigraphy in patients with suspected pulmonary embolism

  Alderson, P. O., Biello, D. R., Gottschalk, A., Hoffer, P. B., Kroop, S. A., Lee, M. E., Ramanna, L., Siegel, B. A. & Waxman, A. D., Jan 1 1984, In: Radiology. 153, 2, p. 515-521 7 p.

  Research output: Contribution to journal › Article › peer-review
  71 Scopus citations

• Tc-99m MDP scintigraphy in a case of idiopathic calcinosis cutis

  Bhattacharya, A., Prasad, V., Thomas, E. J., Singh, B. & Mittal, B. R., Jun 2005, In: Clinical nuclear medicine. 30, 6, p. 431-432 2 p.

  Research output: Contribution to journal › Article › peer-review
  6 Scopus citations

• Tc-99m MDP uptake in a soft tissue hematoma of the chest wall

  Bhattacharya, A., Prasad, V. & Mittal, B. R., Jul 2004, In: Clinical nuclear medicine. 29, 7, p. 454-455 2 p.

  Research output: Contribution to journal › Article › peer-review
  5 Scopus citations

• Tc-99m sulfur colloid scintigraphy for detecting perigraft flow following endovascular aortic aneurysm repair: A feasibility study

  Hovsepian, D. M., Siegel, B. A., Kimbiris, G., Sicard, G. A., Allen, B. T. & Picus, D., Nov 1 1999, In: Cardiovascular and Interventional Radiology. 22, 6, p. 447-451 5 p.

  Research output: Contribution to journal › Article › peer-review
  10 Scopus citations

• TCAB1: A potential target for diagnosis and therapy of head and neck carcinomas

  Sun, C. K., Luo, X. B., Gou, Y. P., Hu, L., Wang, K., Li, C., Xiang, Z. T., Zhang, P., Kong, X. L., Zhang, C. L., Yang, Q., Li, J., Xiao, L. Y., Li, Y. & Chen, Q. M., Jul 28 2014, In: Molecular Cancer. 13, 1, 180.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  26 Scopus citations

• T-cadherin-mediated cell growth regulation involves G₂ phase arrest and requires p21^CIP1/WAF1 expression

  Huang, Z. Y., Wu, Y. L., Hedrick, N. & Gutmann, D. H., Jan 2003, In: Molecular and cellular biology. 23, 2, p. 566-578 13 p.

  Research output: Contribution to journal › Article › peer-review
  78 Scopus citations

• T-cadherin modulates endothelial barrier function

  Andreeva, A. V., Han, J., Kutuzov, M. A., Profirovic, J., Tkachuk, V. A. & Voyno-Yasenetskaya, T. A., Apr 1 2010, In: Journal of Cellular Physiology. 223, 1, p. 94-102 9 p.

  Research output: Contribution to journal › Article › peer-review
  19 Scopus citations

• TC a singolo detettore versus TC a detettore multiplo: Confronto fra sedazione, angiografie convenzionali ed artefatti da movimento, nei pazienti pediatrici dopo trapianto epatico

  Translated title of the contribution: Single- versus multidetector-row CT: Comparison of sedation rates, conventional angiograms and motion artefacts in young children following liver transplantationLemos, A. A., Siegel, M. J., Rossi, G., Somalvico, F., Cioffi, U. & Biondetti, P. R., Oct 2006, In: Radiologia Medica. 111, 7, p. 911-920 10 p.

  Research output: Contribution to journal › Article › peer-review
  7 Scopus citations

• TCEB1-mutated renal cell carcinoma: A distinct genomic and morphological subtype

  Hakimi, A. A., Tickoo, S. K., Jacobsen, A., Sarungbam, J., Sfakianos, J. P., Sato, Y., Morikawa, T., Kume, H., Fukayama, M., Homma, Y., Chen, Y. B., Sankin, A. I., Mano, R., Coleman, J. A., Russo, P., Ogawa, S., Sander, C., Hsieh, J. J. & Reuter, V. E., Jun 1 2015, In: Modern Pathology. 28, 6, p. 845-853 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  95 Scopus citations

• T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na⁺/K⁺-ATPase

  Musch, M. W., Clarke, L. L., Mamah, D., Gawenis, L. R., Zhang, Z., Ellsworth, W., Shalowitz, D., Mittal, N., Efthimiou, P., Alnadjim, Z., Hurst, S. D., Chang, E. B. & Barrett, T. A., Dec 2002, In: Journal of Clinical Investigation. 110, 11, p. 1739-1747 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  153 Scopus citations

• T cell activation induces human osteoclast formation via receptor activator of nuclear factor κB ligand-dependent and -independent mechanisms

  Weitzmann, M. N., Cenci, S., Rifas, L., Haug, J., Dipersio, J. & Pacifici, R., Jan 1 2001, In: Journal of Bone and Mineral Research. 16, 2, p. 328-337 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  142 Scopus citations

• T-cell activation promotes tumorigenesis in inflammation-associated cancer

  Rauch, D., Gross, S., Harding, J., Bokhari, S., Niewiesk, S., Lairmore, M., Piwnica-Worms, D. & Ratner, L., Dec 17 2009, In: Retrovirology. 6, 116.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  29 Scopus citations

• T-cell activation results in microheterogeneous changes in glycosylation of CD45

  Hernandez, J. D., Klein, J., Van Dyken, S. J., Marth, J. D. & Baum, L. G., Jul 2007, In: International Immunology. 19, 7, p. 847-856 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  31 Scopus citations

• T cell activation via cell-surface antigens other than the CD3/T cell receptor complex.

  Yokoyama, W. M. & Shevach, E. M., 1989, In: The Year in immunology. 4, p. 110-146 37 p.

  Research output: Contribution to journal › Review article › peer-review

  7 Scopus citations

• T cell– and monocyte-specific RNA-sequencing analysis in septic and nonseptic critically ill patients and in patients with cancer

  Washburn, M. L., Wang, Z., Walton, A. H., Peter Goedegebuure, S., Figueroa, D. J., van Horn, S., Grossman, J., Remlinger, K., Madsen, H., Brown, J., Srinivasan, R., Wolf, A. I., Berger, S. B., Yi, V. N., Hawkins, W. G., Fields, R. C. & Hotchkiss, R. S., Oct 1 2019, In: Journal of Immunology. 203, 7, p. 1897-1908 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Scopus citations

• T cell autoimmunity in the central nervous system - a new twist at an old rope

  Raine, C. S. & Cross, A. H., Jan 1 1990, In: Laboratory Investigation. 62, 2, p. 133-134 2 p.

  Research output: Contribution to journal › Editorial

  1 Scopus citations

• T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma

  Lozano, A. X., Chaudhuri, A. A., Nene, A., Bacchiocchi, A., Earland, N., Vesely, M. D., Usmani, A., Turner, B. E., Steen, C. B., Luca, B. A., Badri, T., Gulati, G. S., Vahid, M. R., Khameneh, F., Harris, P. K., Chen, D. Y., Dhodapkar, K., Sznol, M., Halaban, R. & Newman, A. M., Feb 2022, In: Nature medicine. 28, 2, p. 353-362 10 p.

  Research output: Contribution to journal › Article › peer-review
  40 Scopus citations

• T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides

  Sufficool, K. E., Lockwood, C. M., Abel, H. J., Hagemann, I. S., Schumacher, J. A., Kelley, T. W. & Duncavage, E. J., Aug 1 2015, In: Journal of the American Academy of Dermatology. 73, 2, p. 228-236.e2

  Research output: Contribution to journal › Article › peer-review

  Open Access
  57 Scopus citations

• T cell co-stimulation and in vivo tolerance

  Lenschow, D. J. & Bluestone, J. A., Oct 1993, In: Current Opinion in Immunology. 5, 5, p. 747-752 6 p.

  Research output: Contribution to journal › Article › peer-review
  75 Scopus citations

• T cell costimulation through the CD28 receptor.

  Green, J. M., Noel, P. J., Sperling, A. I., Walunas, T. L., Lenschow, D. J., Stack, R., Gray, G. S., Bluestone, J. A. & Thompson, C. B., Apr 1995, In: Proceedings of the Association of American Physicians. 107, 1, p. 41-46 6 p.

  Research output: Contribution to journal › Article › peer-review

  15 Scopus citations

• T cell costimulatory molecule function determines susceptibility to infection with Pneumocystis carinii in mice

  Beck, J. M., Blackmon, M. B., Rose, C. M., Kimzey, S. L., Preston, A. M. & Green, J. M., Aug 15 2003, In: Journal of Immunology. 171, 4, p. 1969-1977 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Scopus citations

• T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

  Kipnis, J., Cohen, H., Cardon, M., Ziv, Y. & Schwartz, M., May 21 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 21, p. 8180-8185 6 p.

  Research output: Contribution to journal › Article › peer-review
  344 Scopus citations

• T Cell-Depleted Partial Matched Unrelated Donor Transplant for Advanced Myeloid Malignancy: KIR Ligand Mismatch and Outcome

  Weisdorf, D., Cooley, S., Devine, S., Fehniger, T. A., DiPersio, J., Anasetti, C., Waller, E. K., Porter, D., Farag, S., Drobyski, W., Defor, T., Haagenson, M., Curtsinger, J. & Miller, J., Jun 2012, In: Biology of Blood and Marrow Transplantation. 18, 6, p. 937-943 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Scopus citations

• T-cell deplete versus T-cell replete haploidentical hematopoietic stem cell transplantation for sickle cell disease: where are we?

  Patel, D. A., Akinsete, A. M., Connelly, J. A. & Kassim, A. A., 2019, In: Expert Review of Hematology. 12, 9, p. 733-752 20 p.

  Research output: Contribution to journal › Review article › peer-review
  5 Scopus citations

• T cell-derived antigen binding molecules (TABM): Molecular and functional properties

  Cone, R. E., Zheng, H., Chue, B., Beaman, K., Ferguson, T. & Green, D. R., 1988, In: International Reviews of Immunology. 3, 3, p. 205-228 24 p.

  Research output: Contribution to journal › Article › peer-review
  14 Scopus citations

• T cell development in mice lacking all T cell receptor ζ family members (ζ, η, and FcεRIγ)

  Shores, E. W., Ono, M., Kawabe, T., Sommers, C. L., Tran, T., Lui, K., Udey, M. C., Ravetch, J. & Love, P. E., Apr 6 1998, In: Journal of Experimental Medicine. 187, 7, p. 1093-1101 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  45 Scopus citations

• T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis

  Divekar, R. D., Haymaker, C. L., Cascio, J. A., Guloglu, B. F., Ellis, J. S., Tartar, D. M., Hoeman, C. M., Franklin, C. L., Zinselmeyer, B. H., Lynch, J. N., Miller, M. J. & Zaghouani, H., Oct 15 2011, In: Journal of Immunology. 187, 8, p. 3979-3986 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Scopus citations

• T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201

  Dudek, N. L., Maier, S., Chen, Z. J., Mudd, P. A., Mannering, S. I., Jackson, D. C., Zeng, W., Keech, C. L., Hamlin, K., Pan, Z. J., Davis-Schwarz, K., Workman-Azbill, J., Bachmann, M., McCluskey, J. & Farris, A. D., Oct 2007, In: Arthritis and rheumatism. 56, 10, p. 3387-3398 12 p.

  Research output: Contribution to journal › Article › peer-review
  20 Scopus citations

• T-cell exhaustion signatures vary with tumor type and are severe in glioblastoma

  Woroniecka, K., Chongsathidkiet, P., Rhodin, K., Kemeny, H., Dechant, C., Harrison Farber, S., Elsamadicy, A. A., Cui, X., Koyama, S., Jackson, C., Hansen, L. J., Johanns, T. M., Sanchez-Perez, L., Chandramohan, V., Yu, Y. R. A., Bigner, D. D., Giles, A., Healy, P., Dranoff, G., Weinhold, K. J., & 2 othersDunn, G. P. & Fecci, P. E., Sep 1 2018, In: Clinical Cancer Research. 24, 17, p. 4175-4186 12 p.

  Research output: Contribution to journal › Article › peer-review
  282 Scopus citations

• T cell expression of MyD88 is required for resistance to Toxoplasma gondii

  LaRosa, D. F., Stumhofer, J. S., Gelman, A. E., Rahman, A. H., Taylor, D. K., Hunter, C. A. & Turka, L. A., Mar 25 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 10, p. 3855-3860 6 p.

  Research output: Contribution to journal › Article › peer-review
  87 Scopus citations

• T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice

  Ferrick, D. A., Sambhara, S. R., Ballhausen, W., Iwamoto, A., Pircher, H., Walker, C. L., Yokoyama, W. M., Miller, R. G. & Mak, T. W., May 5 1989, In: Cell. 57, 3, p. 483-492 10 p.

  Research output: Contribution to journal › Article › peer-review
  43 Scopus citations

• T cell genetic background determines default t helper phenotype development in vitro

  Hsieh, C. S., Macatonia, S. E., O’Garra, A. & Murphy, K. M., Feb 1 1995, In: Journal of Experimental Medicine. 181, 2, p. 713-721 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  418 Scopus citations

• T Cell Genetic Background Determines Maintenance of IL-2 Signaling: Effects on BALB/c and B10.D2 T Helper Cell Type 1 Phenotype Development

  Güler, M. L., Jacobson, N. G., Gubler, U. & Murphy, K. M., Aug 15 1997, In: Journal of Immunology. 159, 4, p. 1767-1774 8 p.

  Research output: Contribution to journal › Article › peer-review

  95 Scopus citations

• T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

  Kipnis, J., Yoles, E., Porat, Z., Cohen, A., Mor, F., Sela, M., Cohen, I. R. & Schwartz, M., Jun 20 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 13, p. 7446-7451 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  283 Scopus citations

• T cell immunodominance is dictated by the positively selecting self-peptide

  Lo, W. L., Solomon, B. D., Donermeyer, D. L., Hsieh, C. S. & Allen, P. M., Jan 14 2014, In: eLife. 2014, 3, e01457.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Scopus citations

• T cell-independent macrophage activation in scid mice.

  Bancroft, G. J., Schreiber, R. D. & Unanue, E. R., 1989, In: Current topics in microbiology and immunology. 152, p. 235-242 8 p.

  Research output: Contribution to journal › Article › peer-review

  26 Scopus citations

• T cell independent mechanism for copolymer-1-induced neuroprotection

  Liu, J., Johnson, T. V., Lin, J., Ramirez, S. H., Bronich, T. K., Caplan, S., Persidsky, Y., Gendelman, H. E. & Kipnis, J., Nov 2007, In: European Journal of Immunology. 37, 11, p. 3143-3154 12 p.

  Research output: Contribution to journal › Article › peer-review
  60 Scopus citations

• T cell inducing determinants contain a hierarchy of residues contacting the T cell receptor

  Evavold, B. D., Williams, S. G., Chen, J. S. & Allen, P. M., Dec 1 1991, In: Seminars in immunology. 3, 4, p. 225-229 5 p.

  Research output: Contribution to journal › Article › peer-review

  13 Scopus citations

• T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of T(H)1 and T(H)2 subsets

  Weaver, C. T., Duncan, L. M. & Unanue, E. R., 1989, In: Journal of Immunology. 142, 10, p. 3469-3476 8 p.

  Research output: Contribution to journal › Article › peer-review

  15 Scopus citations

• T cell induction of membrane IL 1 on macrophages

  Weaver, C. T. & Unanue, E. R., 1986, In: Journal of Immunology. 137, 12, p. 3868-3873 6 p.

  Research output: Contribution to journal › Article › peer-review

  56 Scopus citations

• T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas

  Pollack, S. M., He, Q., Yearley, J. H., Emerson, R., Vignali, M., Zhang, Y., Redman, M. W., Baker, K. K., Cooper, S., Donahue, B., Loggers, E. T., Cranmer, L. D., Spraker, M. B., Seo, Y. D., Pillarisetty, V. G., Ricciotti, R. W., Hoch, B. L., McClanahan, T. K., Murphy, E., Blumenschein, W. M., & 4 othersTownson, S. M., Benzeno, S., Riddell, S. R. & Jones, R. L., Sep 1 2017, In: Cancer. 123, 17, p. 3291-3304 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  156 Scopus citations

• T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment

  Cheung, T. C., Oborne, L. M., Steinberg, M. W., Macauley, M. G., Fukuyama, S., Sanjo, H., D'Souza, C., Norris, P. S., Pfeffer, K., Murphy, K. M., Kronenberg, M., Spear, P. G. & Ware, C. F., Dec 1 2009, In: Journal of Immunology. 183, 11, p. 7286-7296 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  101 Scopus citations

• T-cell lymphoma: Recent advances in characterization and new opportunities for treatment

  Casulo, C., O'Connor, O., Shustov, A., Fanale, M., Friedberg, J. W., Leonard, J. P., Kahl, B. S., Little, R. F., Pinter-Brown, L., Advani, R. & Horwitz, S., Feb 2017, In: Journal of the National Cancer Institute. 109, 2

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  21 Scopus citations

• T-cell lymphomas, version 1.2021 featured updates to the NCCN guidelines

  Horwitz, S. M., Ansell, S., Ai, W. Z., Barnes, J., Barta, S. K., Clemens, M. W., Dogan, A., Goodman, A. M., Goyal, G., Guitart, J., Halwani, A., Haverkos, B. M., Hoppe, R. T., Jacobsen, E., Jagadeesh, D., Jones, A., Kim, Y. H., Mehta-Shah, N., Olsen, E. A., Pro, B., & 13 othersRajguru, S. A., Rozati, S., Said, J., Shaver, A., Shustov, A., Sokol, L., Torka, P., Torres-Cabala, C., Wilcox, R., William, B. M., Zain, J., Dwyer, M. A. & Sundar, H., Nov 2020, In: JNCCN Journal of the National Comprehensive Cancer Network. 18, 11, p. 1460-1467 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  17 Scopus citations

• T-Cell Lymphomas, Version 2.2018 Featured Updates to the NCCN Guidelines

  Horwitz, S. M., Ansell, S. M., Ai, W. Z., Barnes, J., Barta, S. K., Choi, M., Clemens, M. W., Dogan, A., Greer, J. P., Halwani, A., Bradley, M. H., Hoppe, R. T., Jacobsen, E., Jagadeesh, D., Kim, Y. H., Lunning, M. A., Mehta, A., Mehta-Shah, N., Oki, Y., Olsen, E. A., & 11 othersPro, B., Rajguru, S. A., Shanbhag, S., Shustov, A., Sokol, L., Torka, P., Wilcox, R., William, B., Zain, J., Dwyer, M. A. & Sundar, H., Feb 1 2018, In: JNCCN Journal of the National Comprehensive Cancer Network. 16, 2, p. 123-135 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  40 Scopus citations

• T-Cell Lymphomas, Version 2.2022

  Horwitz, S. M., Ansell, S., Ai, W. Z., Barnes, J., Barta, S. K., Brammer, J., Clemens, M. W., Dogan, A., Foss, F., Ghione, P., Goodman, A. M., Guitart, J., Halwani, A., Haverkos, B. M., Hoppe, R. T., Jacobsen, E., Jagadeesh, D., Jones, A., Kallam, A., Kim, Y. H., & 16 othersKumar, K., Mehta-Shah, N., Olsen, E. A., Rajguru, S. A., Rozati, S., Said, J., Shaver, A., Shea, L., Shinohara, M. M., Sokol, L., Torres-Cabala, C., Wilcox, R., Wu, P., Zain, J., Dwyer, M. & Sundar, H., Mar 2022, In: JNCCN Journal of the National Comprehensive Cancer Network. 20, 3, p. 285-308 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Scopus citations

• T cell-mediated delay of spontaneous mammary tumor onset: Increased efficacy with in vivo versus in vitro activation

  O'Mara, L. A., Norian, L. A., Kreamalmeyer, D., White, J. M. & Allen, P. M., Apr 15 2005, In: Journal of Immunology. 174, 8, p. 4662-4669 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Scopus citations

• T-cell non-Hodgkin's lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-α) inhibitors: Results of the REFURBISH study

  Deepak, P., Sifuentes, H., Sherid, M., Stobaugh, D., Sadozai, Y. & Ehrenpreis, E. D., Jan 1 2013, In: American Journal of Gastroenterology. 108, 1, p. 99-105 7 p.

  Research output: Contribution to journal › Article › peer-review
  160 Scopus citations