8 The lod score method

John P. Rice, Nancy L. Saccone, Jonathan Corbett

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Scopus citations

Abstract

The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage. In addition, the method is sequential, so that pedigrees or lod curves may be combined from published reports to pool data for analysis. This approach has been remarkably successful for 50 years in identifying disease genes for Mendelian disorders. After discussing these issues, we consider the situation for complex disorders, where the maximum lod score (MLS) statistic shares some of the advantages of the traditional lod score approach but is llimited by unknown power and the lack of sharing of the primary data needed to optimally combine analytic results. We may still learn from the lod score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes.

Original languageEnglish
Title of host publicationAdvances in Genetics
PublisherAcademic Press Inc.
Pages99-113
Number of pages15
ISBN (Print)0120176424, 9780120176427
DOIs
StatePublished - 2001

Publication series

NameAdvances in Genetics
Volume42
ISSN (Print)0065-2660

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