68Ga-DOTATOC PET for Treatment Efficacy Evaluation of Cardiac Sarcoidosis

Alessio Imperiale, Vincent Poindron, Matias Martinez, Patrick Ohlmann, Thomas H. Schindler, Soraya El Ghannudi

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac sarcoidosis (CS) has a poor prognosis related to life-threating arrhythmias and heart failure. Treatment includes anti-inflammatory therapies and implantable pacemaker and/or cardioverter defibrillator. The presence of cardiac devices and physiologic myocardial glucose uptake are major limitations of both cardiac magnetic resonance and F-FDG PET/CT, reducing their diagnostic value. Somatostatin-based PET/CT has been proposed to detect active CS. Contrarily to F-FDG uptake, which reflects nonspecific leukocyte infiltration, Ga-DOTATOC may identify active granulomatosis. Herein, we underline the specificity of Ga-DOTATOC PET in challeging clinical situations including refractory CS, and chronic CS in patients with cardiac device, or false-positive F-FDG PET/CT results.

Original languageEnglish
Pages (from-to)e416-e418
JournalClinical nuclear medicine
Volume45
Issue number9
DOIs
StatePublished - Sep 1 2020

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