@inbook{76ad476c3a044892b4a8b5a5c4b55a3b,
title = "6 Definition of the phenotype",
abstract = "Definition of the phenotype is a key issue in designing any genetic study whose goal is to detect disease genes. This chapter describes strategies to increase the power to detect susceptibility loci for complex diseases. A narrowly defined disease phenotype can offer advantages over broad definitions. Studies of clinical disease can also benefit from judicious selection of endophenotypes and related quantitative traits for analysis. The effect of diagnostic and measurement error is also discussed; power is maximized when strategies to reduce error are incorporated into a study design.",
author = "Rice, {John P.} and Saccone, {Nancy L.} and Erik Rasmussen",
note = "Funding Information: This work was supported in part by grants MH37685, MH31302, AA12239, and ME117104 (NLS, ER) from the National Institutes of Health. Special thanks to Christine Roark for preparation of this manuscript.",
year = "2001",
doi = "10.1016/s0065-2660(01)42015-3",
language = "English",
isbn = "0120176424",
series = "Advances in Genetics",
publisher = "Academic Press Inc.",
pages = "69--76",
booktitle = "Advances in Genetics",
}