6-acetylmorphine detected in the absence of morphine in pain management patients

Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Cameron West, Amadeo Pesce, Patrick Friel

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Liquid chromatography tandem mass spectrometry was used to identify and confirm the presence of 6-acetylmorphine and morphine in 22,361 urines of pain management patients. Thirty urines tested positive for 6-acetylmorphine above a cutoff of 10 ng/mL. Twenty-three percent of the patients with urinary concentrations of 6-acetylmorphine above 10 ng/mL had urinary morphine concentrations below 300 ng/mL.

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalTherapeutic Drug Monitoring
Issue number6
StatePublished - Dec 2009


  • 6-Acetylmorphine
  • Cutoffs
  • Morphine
  • Pain patients
  • Urinary excretion


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