6-acetylmorphine detected in the absence of morphine in pain management patients

Bridgit Crews; Charles Mikel; Sergey Latyshev; Robert West; Cameron West; Amadeo Pesce; Patrick Friel

doi:10.1097/FTD.0b013e3181b9da04

6-acetylmorphine detected in the absence of morphine in pain management patients

Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Cameron West, Amadeo Pesce, Patrick Friel

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Liquid chromatography tandem mass spectrometry was used to identify and confirm the presence of 6-acetylmorphine and morphine in 22,361 urines of pain management patients. Thirty urines tested positive for 6-acetylmorphine above a cutoff of 10 ng/mL. Twenty-three percent of the patients with urinary concentrations of 6-acetylmorphine above 10 ng/mL had urinary morphine concentrations below 300 ng/mL.

Original language	English
Pages (from-to)	749-752
Number of pages	4
Journal	Therapeutic Drug Monitoring
Volume	31
Issue number	6
DOIs	https://doi.org/10.1097/FTD.0b013e3181b9da04
State	Published - Dec 2009

Keywords

6-Acetylmorphine
Cutoffs
Morphine
Pain patients
Urinary excretion

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10.1097/FTD.0b013e3181b9da04

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abstract = "Liquid chromatography tandem mass spectrometry was used to identify and confirm the presence of 6-acetylmorphine and morphine in 22,361 urines of pain management patients. Thirty urines tested positive for 6-acetylmorphine above a cutoff of 10 ng/mL. Twenty-three percent of the patients with urinary concentrations of 6-acetylmorphine above 10 ng/mL had urinary morphine concentrations below 300 ng/mL.",

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AU - Crews, Bridgit

AU - Mikel, Charles

AU - Latyshev, Sergey

AU - West, Robert

AU - West, Cameron

AU - Pesce, Amadeo

AU - Friel, Patrick

PY - 2009/12

Y1 - 2009/12

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AB - Liquid chromatography tandem mass spectrometry was used to identify and confirm the presence of 6-acetylmorphine and morphine in 22,361 urines of pain management patients. Thirty urines tested positive for 6-acetylmorphine above a cutoff of 10 ng/mL. Twenty-three percent of the patients with urinary concentrations of 6-acetylmorphine above 10 ng/mL had urinary morphine concentrations below 300 ng/mL.

KW - 6-Acetylmorphine

KW - Cutoffs

KW - Morphine

KW - Pain patients

KW - Urinary excretion

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ER -

6-acetylmorphine detected in the absence of morphine in pain management patients

Abstract

Keywords

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