53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Elsa Callen; Dali Zong; Wei Wu; Nancy Wong; Andre Stanlie; Momoko Ishikawa; Raphael Pavani; Lavinia C. Dumitrache; Andrea K. Byrum; Carlos Mendez-Dorantes; Paula Martinez; Andres Canela; Yaakov Maman; Amanda Day; Michael J. Kruhlak; Maria A. Blasco; Jeremy M. Stark; Nima Mosammaparast; Peter J. McKinnon; André Nussenzweig

doi:10.1016/j.molcel.2019.09.024

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Elsa Callen, Dali Zong, Wei Wu, Nancy Wong, Andre Stanlie, Momoko Ishikawa, Raphael Pavani, Lavinia C. Dumitrache, Andrea K. Byrum, Carlos Mendez-Dorantes, Paula Martinez, Andres Canela, Yaakov Maman, Amanda Day, Michael J. Kruhlak, Maria A. Blasco, Jeremy M. Stark, Nima Mosammaparast, Peter J. McKinnon, André Nussenzweig

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

BRCA1 promotes 5′-3′ end resection and subsequently loads RAD51 onto 3′ single-stranded DNA to initiate homologous recombination. Callen et al. demonstrate that 53BP1 antagonizes both key steps in homologous recombination—end resection and RAD51 loading—that are coordinated by BRCA1.

Original language	English
Pages (from-to)	26-38.e7
Journal	Molecular cell
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2019.09.024
State	Published - Jan 2 2020

Keywords

53BP1
BRCA1
PARPi
aging
cancer
homologous recombination
resection
shieldin

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10.1016/j.molcel.2019.09.024

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Callen, E., Zong, D., Wu, W., Wong, N., Stanlie, A., Ishikawa, M., Pavani, R., Dumitrache, L. C., Byrum, A. K., Mendez-Dorantes, C., Martinez, P., Canela, A., Maman, Y., Day, A., Kruhlak, M. J., Blasco, M. A., Stark, J. M., Mosammaparast, N., McKinnon, P. J., & Nussenzweig, A. (2020). 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Molecular cell, 77(1), 26-38.e7. https://doi.org/10.1016/j.molcel.2019.09.024

@article{e9934be1ee744504a5101bd5fddc403f,

title = "53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination",

abstract = "BRCA1 promotes 5′-3′ end resection and subsequently loads RAD51 onto 3′ single-stranded DNA to initiate homologous recombination. Callen et al. demonstrate that 53BP1 antagonizes both key steps in homologous recombination—end resection and RAD51 loading—that are coordinated by BRCA1.",

keywords = "53BP1, BRCA1, PARPi, aging, cancer, homologous recombination, resection, shieldin",

author = "Elsa Callen and Dali Zong and Wei Wu and Nancy Wong and Andre Stanlie and Momoko Ishikawa and Raphael Pavani and Dumitrache, {Lavinia C.} and Byrum, {Andrea K.} and Carlos Mendez-Dorantes and Paula Martinez and Andres Canela and Yaakov Maman and Amanda Day and Kruhlak, {Michael J.} and Blasco, {Maria A.} and Stark, {Jeremy M.} and Nima Mosammaparast and McKinnon, {Peter J.} and Andr{\'e} Nussenzweig",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = jan,

day = "2",

doi = "10.1016/j.molcel.2019.09.024",

language = "English",

volume = "77",

pages = "26--38.e7",

journal = "Molecular cell",

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Callen, E, Zong, D, Wu, W, Wong, N, Stanlie, A, Ishikawa, M, Pavani, R, Dumitrache, LC, Byrum, AK, Mendez-Dorantes, C, Martinez, P, Canela, A, Maman, Y, Day, A, Kruhlak, MJ, Blasco, MA, Stark, JM, Mosammaparast, N, McKinnon, PJ & Nussenzweig, A 2020, '53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination', Molecular cell, vol. 77, no. 1, pp. 26-38.e7. https://doi.org/10.1016/j.molcel.2019.09.024

TY - JOUR

T1 - 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

AU - Callen, Elsa

AU - Zong, Dali

AU - Wu, Wei

AU - Wong, Nancy

AU - Stanlie, Andre

AU - Ishikawa, Momoko

AU - Pavani, Raphael

AU - Dumitrache, Lavinia C.

AU - Byrum, Andrea K.

AU - Mendez-Dorantes, Carlos

AU - Martinez, Paula

AU - Canela, Andres

AU - Maman, Yaakov

AU - Day, Amanda

AU - Kruhlak, Michael J.

AU - Blasco, Maria A.

AU - Stark, Jeremy M.

AU - Mosammaparast, Nima

AU - McKinnon, Peter J.

AU - Nussenzweig, André

PY - 2020/1/2

Y1 - 2020/1/2

N2 - BRCA1 promotes 5′-3′ end resection and subsequently loads RAD51 onto 3′ single-stranded DNA to initiate homologous recombination. Callen et al. demonstrate that 53BP1 antagonizes both key steps in homologous recombination—end resection and RAD51 loading—that are coordinated by BRCA1.

AB - BRCA1 promotes 5′-3′ end resection and subsequently loads RAD51 onto 3′ single-stranded DNA to initiate homologous recombination. Callen et al. demonstrate that 53BP1 antagonizes both key steps in homologous recombination—end resection and RAD51 loading—that are coordinated by BRCA1.

KW - 53BP1

KW - BRCA1

KW - PARPi

KW - aging

KW - cancer

KW - homologous recombination

KW - resection

KW - shieldin

UR - http://www.scopus.com/inward/record.url?scp=85076886017&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2019.09.024

DO - 10.1016/j.molcel.2019.09.024

M3 - Article

C2 - 31653568

AN - SCOPUS:85076886017

SN - 1097-2765

VL - 77

SP - 26-38.e7

JO - Molecular cell

JF - Molecular cell

IS - 1

ER -

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

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