53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Elsa Callen, Dali Zong, Wei Wu, Nancy Wong, Andre Stanlie, Momoko Ishikawa, Raphael Pavani, Lavinia C. Dumitrache, Andrea K. Byrum, Carlos Mendez-Dorantes, Paula Martinez, Andres Canela, Yaakov Maman, Amanda Day, Michael J. Kruhlak, Maria A. Blasco, Jeremy M. Stark, Nima Mosammaparast, Peter J. McKinnon, André Nussenzweig

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

BRCA1 promotes 5′-3′ end resection and subsequently loads RAD51 onto 3′ single-stranded DNA to initiate homologous recombination. Callen et al. demonstrate that 53BP1 antagonizes both key steps in homologous recombination—end resection and RAD51 loading—that are coordinated by BRCA1.

Original languageEnglish
Pages (from-to)26-38.e7
JournalMolecular cell
Volume77
Issue number1
DOIs
StatePublished - Jan 2 2020

Keywords

  • 53BP1
  • BRCA1
  • PARPi
  • aging
  • cancer
  • homologous recombination
  • resection
  • shieldin

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