TY - JOUR
T1 - 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1–3 (TET1–3) proteins in the dorsal root ganglia of mouse
T2 - Expression and dynamic regulation in neuropathic pain
AU - Chamessian, Alexander G.
AU - Qadri, Yawar J.
AU - Cummins, Matthew
AU - Hendrickson, Michele
AU - Berta, Temugin
AU - Buchheit, Thomas
AU - Van de Ven, Thomas
N1 - Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/4/3
Y1 - 2017/4/3
N2 - Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase following nerve injury. Furthermore, we show that the 5hmC-generating Ten-eleven translocation 1–3 (TET1–3) proteins are expressed in a cell-type specific manner in the DRG, with Tet3 displaying differential upregulation after injury, suggesting a potential role in neuropathic pain.
AB - Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase following nerve injury. Furthermore, we show that the 5hmC-generating Ten-eleven translocation 1–3 (TET1–3) proteins are expressed in a cell-type specific manner in the DRG, with Tet3 displaying differential upregulation after injury, suggesting a potential role in neuropathic pain.
KW - Chronic pain
KW - epigenetics
KW - neuropathic pain
UR - http://www.scopus.com/inward/record.url?scp=85014440920&partnerID=8YFLogxK
U2 - 10.1080/08990220.2017.1292237
DO - 10.1080/08990220.2017.1292237
M3 - Article
C2 - 28276837
AN - SCOPUS:85014440920
SN - 0899-0220
VL - 34
SP - 72
EP - 79
JO - Somatosensory and Motor Research
JF - Somatosensory and Motor Research
IS - 2
ER -