5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice

Jonah Padawer-Curry; Joshua Siegel; Jordan McCall; Ginger E. Nicol; Adam Bauer

doi:10.1364/BRAIN.2023.BTu2B.3

5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice

Jonah Padawer-Curry, Joshua Siegel, Jordan McCall, Ginger E. Nicol, Adam Bauer

Research output: Contribution to conference › Paper › peer-review

Abstract

Thy1-jRGECO1a mice were imaged under awake, resting-state conditions using wide-field optical imaging. Non-hallucinogenic 5-HT2a receptor agonism significantly reduced neuronal and hemodynamic bilateral functional connectivity, activity, and neurovascular coupling in a region- and frequency-band-specific manner.

Original language	English
DOIs	https://doi.org/10.1364/BRAIN.2023.BTu2B.3
State	Published - 2023
Event	Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences - Vancouver, Canada Duration: Apr 24 2023 → Apr 27 2023

Conference

Conference	Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences
Country/Territory	Canada
City	Vancouver
Period	04/24/23 → 04/27/23

Access to Document

10.1364/BRAIN.2023.BTu2B.3

Cite this

Padawer-Curry, J., Siegel, J., McCall, J., Nicol, G. E., & Bauer, A. (2023). 5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice. Paper presented at Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver, Canada. https://doi.org/10.1364/BRAIN.2023.BTu2B.3

@conference{fbb674bd6c6e4c27bd2a85551e2e2d85,

title = "5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice",

abstract = "Thy1-jRGECO1a mice were imaged under awake, resting-state conditions using wide-field optical imaging. Non-hallucinogenic 5-HT2a receptor agonism significantly reduced neuronal and hemodynamic bilateral functional connectivity, activity, and neurovascular coupling in a region- and frequency-band-specific manner.",

author = "Jonah Padawer-Curry and Joshua Siegel and Jordan McCall and Nicol, {Ginger E.} and Adam Bauer",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s), {\textcopyright} Optica Publishing Group 2023.; Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences ; Conference date: 24-04-2023 Through 27-04-2023",

year = "2023",

doi = "10.1364/BRAIN.2023.BTu2B.3",

language = "English",

}

Padawer-Curry, J, Siegel, J, McCall, J , Nicol, GE & Bauer, A 2023, '5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice', Paper presented at Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver, Canada, 04/24/23 - 04/27/23. https://doi.org/10.1364/BRAIN.2023.BTu2B.3

5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice. / Padawer-Curry, Jonah; Siegel, Joshua; McCall, Jordan et al.
2023. Paper presented at Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver, Canada.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - 5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice

AU - Padawer-Curry, Jonah

AU - Siegel, Joshua

AU - McCall, Jordan

AU - Nicol, Ginger E.

AU - Bauer, Adam

PY - 2023

Y1 - 2023

N2 - Thy1-jRGECO1a mice were imaged under awake, resting-state conditions using wide-field optical imaging. Non-hallucinogenic 5-HT2a receptor agonism significantly reduced neuronal and hemodynamic bilateral functional connectivity, activity, and neurovascular coupling in a region- and frequency-band-specific manner.

AB - Thy1-jRGECO1a mice were imaged under awake, resting-state conditions using wide-field optical imaging. Non-hallucinogenic 5-HT2a receptor agonism significantly reduced neuronal and hemodynamic bilateral functional connectivity, activity, and neurovascular coupling in a region- and frequency-band-specific manner.

UR - http://www.scopus.com/inward/record.url?scp=85193058560&partnerID=8YFLogxK

U2 - 10.1364/BRAIN.2023.BTu2B.3

DO - 10.1364/BRAIN.2023.BTu2B.3

M3 - Paper

AN - SCOPUS:85193058560

T2 - Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences

Y2 - 24 April 2023 through 27 April 2023

ER -

Padawer-Curry J, Siegel J, McCall J , Nicol GE , Bauer A. 5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice. 2023. Paper presented at Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver, Canada. doi: 10.1364/BRAIN.2023.BTu2B.3

5-HT2A Receptor Agonism Changes Neuronal Network Activityand Disrupts Neurovascular Coupling in Mice

Abstract

Conference

Access to Document

Other files and links

Fingerprint

Cite this