5, 8, 11, 14 - Eicosatetranoic acid (ETYA) inhibits binding of N-Formyl-methionly-leucyl-phenylalanine (FLMP) to its receptor on human granulocytes. A note of caution

John P. Atkinson, Louis Simchowitz, Jagdish Mehta, William F. Stenson

Research output: Contribution to journalArticle

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Abstract

Binding of two biochemically distinct chemotactic factors, FMLP and C5a, to their respective receptors on human granulocytes produces a transient several-fold increase in cAMP. To determine if arachidonic acid metabolites were responsible for the increased cAMP concentrations, two inhibitors of arachidonic acid metabolism, indomethacin and ETYA, were incubated with granulocytes prior to exposure to FMLP or C5a. ETYA, but not indomethacin, inhibited both the cAMP and superoxide responses to a similar degree. However, the mechanism of this effect was found to be through inhibition of the binding of FMLP to its receptor rather than through inhibition of arachidonate metabolism.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalImmunopharmacology
Volume4
Issue number1
DOIs
StatePublished - Feb 1982

Keywords

  • Binding to receptor
  • ETYA
  • FMLP
  • Inhibition of receptor-ligand binding

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