3D Printing of Poloxamer 407 Nanogel Discs and Their Applications in Adjuvant Ovarian Cancer Therapy

Hyunah Cho, Udayabhanu Jammalamadaka, Karthik Tappa, Christopher Egbulefu, Julie Prior, Rui Tang, Samuel Achilefu

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Nanogels are attractive biocompatible materials that enable local delivery of multiple drugs. In this study, we demonstrated that 3D printing technology could be used to precisely construct nanogel discs carrying paclitaxel and rapamycin. 3D-printed nanogel disc rounds (12 mm diameter × 1 mm thickness) carrying paclitaxel and rapamycin evaded premature gelation during storage and the initial burst release of the drugs in the dissolution medium. In vivo 3D-printed nanogel discs permitted successful intraperitoneal delivery of paclitaxel and rapamycin in ES-2-luc ovarian-cancer-bearing xenograft mice. They were also shown to be therapeutically effective and capable of preventing postsurgical peritoneal adhesions in the treated xenograft mice.

Original languageEnglish
Pages (from-to)552-560
Number of pages9
JournalMolecular Pharmaceutics
Volume16
Issue number2
DOIs
StatePublished - Feb 4 2019

Keywords

  • 3D printing
  • ovarian cancer
  • paclitaxel
  • peritoneal adhesion
  • poloxamer

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