3D computational mechanical analysis for human atherosclerotic plaques using MRI-based models with fluid-structure interactions

Dalin Tang, Chun Yang, Jie Zheng, Pamela K. Woodard, Gregorio A. Sicard, Jeffrey E. Saffitz, Shunichi Kobayashi, Thomas K. Pilgram, Chun Yuan

Research output: Contribution to journalConference articlepeer-review

10 Scopus citations

Abstract

Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. It is believed that mechanical forces play an important role in plaque progression and rupture. A three-dimensional (3D) MRI-based finite-element model with multi-component plaque structure and fluid-structure interactions (FSI) is introduced to perform mechanical analysis for human atherosclerotic plaques and identify critical flow and stress/strain conditions which may be related to plaque rupture. The coupled fluid and structure models are solved by ADINA, a well-tested finite-element package. Our results indicate that pressure conditions, plaque structure, component size and location, material properties, and model assumptions all have considerable effects on flow and plaque stress/strain behaviors. Large-scale patient studies are needed to validate the computational findings. This FSI model provides more complete stress/strain analysis and better interpretation of information from MR images and may lead to more accurate plaque vulnerability assessment and rupture predictions.

Original languageEnglish
Pages (from-to)328-336
Number of pages9
JournalLecture Notes in Computer Science
Volume3217
Issue number1 PART 2
StatePublished - Dec 1 2004
EventMedical Image Computing and Computer-Assisted Intervention, MICCAI 2004 - 7th International Conference, Proceedings - Saint-Malo, France
Duration: Sep 26 2004Sep 29 2004

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