TY - JOUR
T1 - 3′,5′-Cyclic dinucleoside phosphates
T2 - Undesirable intermediates in the phosphotriester approach to oligonucleotide synthesis
AU - Van Boom, Jacques H.
AU - Burgers, Peter M.J.
AU - Van Deursen, Peter H.
AU - De Rooy, Jan F.M.
AU - Reese, Colin B.
PY - 1976/12/1
Y1 - 1976/12/1
N2 - Mild alkaline hydrolysis of (4a) gives the 3′,5′-cyclic dinucleoside phosphate (5a); more drastic alkaline hydrolysis of phosphotriester intermediates with free vicinal 5′- or 3′-hydroxy functions [(4a) and (7b), or (6a) and (8b)] leads to products with, respectively, 5′ → 5′- or 3′ → 3′-in addition to 3′ → 5′-internucleotide linkages.
AB - Mild alkaline hydrolysis of (4a) gives the 3′,5′-cyclic dinucleoside phosphate (5a); more drastic alkaline hydrolysis of phosphotriester intermediates with free vicinal 5′- or 3′-hydroxy functions [(4a) and (7b), or (6a) and (8b)] leads to products with, respectively, 5′ → 5′- or 3′ → 3′-in addition to 3′ → 5′-internucleotide linkages.
UR - https://www.scopus.com/pages/publications/37049111473
U2 - 10.1039/C39760000167
DO - 10.1039/C39760000167
M3 - Article
AN - SCOPUS:37049111473
SN - 0022-4936
SP - 167
EP - 168
JO - Journal of the Chemical Society, Chemical Communications
JF - Journal of the Chemical Society, Chemical Communications
IS - 5
ER -