3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Thomas D. Penning; Steven W. Kramer; Len F. Lee; Paul W. Collins; Carol M. Koboldt; Karen Seibert; Amy W. Veenhuizen; Yan Y. Zhang; Peter C. Isakson

doi:10.1016/S0960-894X(97)00372-7

3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Thomas D. Penning, Steven W. Kramer, Len F. Lee, Paul W. Collins, Carol M. Koboldt, Karen Seibert, Amy W. Veenhuizen, Yan Y. Zhang, Peter C. Isakson

Department of Anesthesiology

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Abstract

A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.

Original language	English
Pages (from-to)	2121-2124
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	16
DOIs	https://doi.org/10.1016/S0960-894X(97)00372-7
State	Published - Aug 19 1997

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title = "3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2",

abstract = "A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.",

author = "Penning, {Thomas D.} and Kramer, {Steven W.} and Lee, {Len F.} and Collins, {Paul W.} and Koboldt, {Carol M.} and Karen Seibert and Veenhuizen, {Amy W.} and Zhang, {Yan Y.} and Isakson, {Peter C.}",

year = "1997",

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doi = "10.1016/S0960-894X(97)00372-7",

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T1 - 3,4-diarylpyrazoles

T2 - Potent and selective inhibitors of cyclooxygenase-2

AU - Penning, Thomas D.

AU - Kramer, Steven W.

AU - Lee, Len F.

AU - Collins, Paul W.

AU - Koboldt, Carol M.

AU - Seibert, Karen

AU - Veenhuizen, Amy W.

AU - Zhang, Yan Y.

AU - Isakson, Peter C.

PY - 1997/8/19

Y1 - 1997/8/19

N2 - A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.

AB - A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.

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U2 - 10.1016/S0960-894X(97)00372-7

DO - 10.1016/S0960-894X(97)00372-7

M3 - Article

AN - SCOPUS:0030877109

SN - 0960-894X

VL - 7

SP - 2121

EP - 2124

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Abstract

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