3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Thomas D. Penning, Steven W. Kramer, Len F. Lee, Paul W. Collins, Carol M. Koboldt, Karen Seibert, Amy W. Veenhuizen, Yan Y. Zhang, Peter C. Isakson

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat carrageenan-induced foot pad edema assay.

Original languageEnglish
Pages (from-to)2121-2124
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number16
StatePublished - Aug 19 1997


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