Neurons receive excitatory inputs via both fast AMPA and slow NMD A type receptors. We find that neurons receiving input via NMDA receptors can have two stable membrane states which are input dependent. Action potentials can only be initiated from the higher voltage state. Similar observations have been made in several brain areas which might be explained by our model. The in-teractions between the two kinds of inputs lead us to suggest that some neurons may operate in 3 states: disabled, enabled and firing. Such enabled, but non-firing modes can be used to introduce context-dependent processing in neural networks. We provide a simple example and discuss possible implications for neuronal processing and response variability.

Original languageEnglish
Title of host publicationAdvances in Neural Information Processing Systems 14 - Proceedings of the 2001 Conference, NIPS 2001
PublisherNeural information processing systems foundation
ISBN (Print)0262042088, 9780262042086
StatePublished - 2002
Event15th Annual Neural Information Processing Systems Conference, NIPS 2001 - Vancouver, BC, Canada
Duration: Dec 3 2001Dec 8 2001

Publication series

NameAdvances in Neural Information Processing Systems
ISSN (Print)1049-5258


Conference15th Annual Neural Information Processing Systems Conference, NIPS 2001
CityVancouver, BC


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