3-Chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

Roland E. Dolle; Denton Hoyer; James M. Rinker; Tina Morgan Ross; Stanley J. Schmidt; Carla T. Helaszek; Mark A. Ator

doi:10.1016/S0960-894X(97)00145-5

3-Chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

Roland E. Dolle, Denton Hoyer, James M. Rinker, Tina Morgan Ross, Stanley J. Schmidt, Carla T. Helaszek, Mark A. Ator

Center for Drug Discovery

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k(obs)/[I] = 355 M^-1s^-1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.

Original language	English
Pages (from-to)	1003-1006
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(97)00145-5
State	Published - Apr 22 1997

Access to Document

10.1016/S0960-894X(97)00145-5

Cite this

@article{145a2f5909184ba8913eea0dabfd81fc,

title = "3-Chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor",

abstract = "The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k(obs)/[I] = 355 M-1s-1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.",

author = "Dolle, {Roland E.} and Denton Hoyer and Rinker, {James M.} and Ross, {Tina Morgan} and Schmidt, {Stanley J.} and Helaszek, {Carla T.} and Ator, {Mark A.}",

year = "1997",

month = apr,

day = "22",

doi = "10.1016/S0960-894X(97)00145-5",

language = "English",

volume = "7",

pages = "1003--1006",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

number = "8",

}

TY - JOUR

T1 - 3-Chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

AU - Dolle, Roland E.

AU - Hoyer, Denton

AU - Rinker, James M.

AU - Ross, Tina Morgan

AU - Schmidt, Stanley J.

AU - Helaszek, Carla T.

AU - Ator, Mark A.

PY - 1997/4/22

Y1 - 1997/4/22

N2 - The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k(obs)/[I] = 355 M-1s-1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.

AB - The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k(obs)/[I] = 355 M-1s-1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.

UR - http://www.scopus.com/inward/record.url?scp=0030900525&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(97)00145-5

DO - 10.1016/S0960-894X(97)00145-5

M3 - Article

AN - SCOPUS:0030900525

SN - 0960-894X

VL - 7

SP - 1003

EP - 1006

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

3-Chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

Abstract

Access to Document

Other files and links

Fingerprint

Cite this