Abstract
The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k(obs)/[I] = 355 M-1s-1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.
Original language | English |
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Pages (from-to) | 1003-1006 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 7 |
Issue number | 8 |
DOIs | |
State | Published - Apr 22 1997 |