3-Chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor

Roland E. Dolle, Denton Hoyer, James M. Rinker, Tina Morgan Ross, Stanley J. Schmidt, Carla T. Helaszek, Mark A. Ator

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k(obs)/[I] = 355 M-1s-1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.

Original languageEnglish
Pages (from-to)1003-1006
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number8
DOIs
StatePublished - Apr 22 1997

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