TY - JOUR
T1 - 2D/3D CMR tissue tracking versus CMR tagging in the assessment of spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction
AU - Zhu, Tong
AU - Zeng, Wen
AU - Chen, Yushu
AU - Zhang, Yu
AU - Sun, Jiayu
AU - Liang, Zhigang
AU - Yang, Zunyuan
AU - Cheng, Wei
AU - Wang, Lei
AU - Song, Bin
AU - Wu, Bing
AU - Wang, Fangtong
AU - Liang, Yinan
AU - Gong, Li
AU - Zheng, Jie
AU - Gao, Fabao
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China [grant number 81520108014, 81771800, 81829003] and the State’s Key Project of Research and Development Plan of China [2016YFA0201402]. The funding sponsors had no role in the design of the study; in the collection, analysis or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/11/26
Y1 - 2018/11/26
N2 - Background: Spontaneous T2DM in rhesus monkeys manifests as isolated diastolic dysfunction in the early stage of diabetic cardiomyopathy, similar to humans. Myocardial deformation measurements have emerged as a superior way to measure left ventricular (LV) function in the early stage of cardiac dysfunction, making it possible to further evaluate early-stage LV dysfunction in spontaneous T2DM rhesus monkeys. Methods: Spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction (T2DM-DD, n=10) and corresponding nondiabetic healthy animals (ND, n=9) were prospectively scanned for a CMR study. Circumferential and longitudinal peak systolic strain (Ecc, Ell), time to peak strain (tEcc, tEll) and peak diastolic strain rate (CSR, LSR) obtained from 2D/3D CMR-TT were compared with those obtained from CMR tagging separately. In addition, all CMR imaging protocols were performed twice in 9 ND animals to assess test-retest reproducibility. Results: Compared with the ND group, the T2DM-DD monkeys demonstrated significantly impaired LV Ecc (-10.63±3.23 vs -14.18±3.19, p<0.05), CSR (65.50±14.48 vs 65.50±14.48, p<0.01), Ell (-9.11±2.59 vs -14.17±1.68, p<0.05), and LSR (59.43±19.17 vs 108.46±22.33, p<0.01) with the tagging. Only Ecc (-13.10±2.47 vs -19.03±3.69, p<0.01) and CSR (148.90±31.27 vs 202.00±51.88, p<0.01) were significantly reduced with 2D CMR-TT, and only Ecc (-13.77±1.98 vs -17.26±3.78, p<0.05) was significantly reduced with 3D CMR-TT. Moreover, 2D/3D CMR-TT-derived Ecc and CSR correlated with the corresponding tagging values collectively, with a statistically significant ICC value (p<0.05). Test-retest repeatability analysis showed that most tagging-derived biomarkers had acceptable repeatability (p<0.01). In addition, 2D CMR-TT-derived indicators were poorer than those derived from the tagging method but better than those obtained using the 3D method, with larger ICCs except for tEcc (p<0.05). Conclusions: LV systolic and diastolic deformations were impaired in spontaneous T2DM rhesus monkeys previously diagnosed with isolated diastolic dysfunction by echocardiography. The 2D CMR-TT-derived Ecc and CSR were effective in the evaluation of the myocardial systolic and diastolic functions of early-diabetic cardiomyopathy, with relatively higher test-retest reproducibility and acceptable correlation with the tagging method compared with the 3D CMR-TT method.
AB - Background: Spontaneous T2DM in rhesus monkeys manifests as isolated diastolic dysfunction in the early stage of diabetic cardiomyopathy, similar to humans. Myocardial deformation measurements have emerged as a superior way to measure left ventricular (LV) function in the early stage of cardiac dysfunction, making it possible to further evaluate early-stage LV dysfunction in spontaneous T2DM rhesus monkeys. Methods: Spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction (T2DM-DD, n=10) and corresponding nondiabetic healthy animals (ND, n=9) were prospectively scanned for a CMR study. Circumferential and longitudinal peak systolic strain (Ecc, Ell), time to peak strain (tEcc, tEll) and peak diastolic strain rate (CSR, LSR) obtained from 2D/3D CMR-TT were compared with those obtained from CMR tagging separately. In addition, all CMR imaging protocols were performed twice in 9 ND animals to assess test-retest reproducibility. Results: Compared with the ND group, the T2DM-DD monkeys demonstrated significantly impaired LV Ecc (-10.63±3.23 vs -14.18±3.19, p<0.05), CSR (65.50±14.48 vs 65.50±14.48, p<0.01), Ell (-9.11±2.59 vs -14.17±1.68, p<0.05), and LSR (59.43±19.17 vs 108.46±22.33, p<0.01) with the tagging. Only Ecc (-13.10±2.47 vs -19.03±3.69, p<0.01) and CSR (148.90±31.27 vs 202.00±51.88, p<0.01) were significantly reduced with 2D CMR-TT, and only Ecc (-13.77±1.98 vs -17.26±3.78, p<0.05) was significantly reduced with 3D CMR-TT. Moreover, 2D/3D CMR-TT-derived Ecc and CSR correlated with the corresponding tagging values collectively, with a statistically significant ICC value (p<0.05). Test-retest repeatability analysis showed that most tagging-derived biomarkers had acceptable repeatability (p<0.01). In addition, 2D CMR-TT-derived indicators were poorer than those derived from the tagging method but better than those obtained using the 3D method, with larger ICCs except for tEcc (p<0.05). Conclusions: LV systolic and diastolic deformations were impaired in spontaneous T2DM rhesus monkeys previously diagnosed with isolated diastolic dysfunction by echocardiography. The 2D CMR-TT-derived Ecc and CSR were effective in the evaluation of the myocardial systolic and diastolic functions of early-diabetic cardiomyopathy, with relatively higher test-retest reproducibility and acceptable correlation with the tagging method compared with the 3D CMR-TT method.
KW - Cardiac MRI
KW - Diabetic cardiomyopathy
KW - Rhesus monkey
KW - Tagging
KW - Tissue tracking
UR - https://www.scopus.com/pages/publications/85057249361
U2 - 10.1186/s12880-018-0288-y
DO - 10.1186/s12880-018-0288-y
M3 - Article
C2 - 30477437
AN - SCOPUS:85057249361
SN - 1471-2342
VL - 18
JO - BMC Medical Imaging
JF - BMC Medical Imaging
IS - 1
M1 - 47
ER -