It has been hypothesized that critical artery stress and strain conditions may be used as indicators to predict possible plaque cap rupture and subsequent onset of cardiovascular diseases. Multi-physics MRI-based 2D nonlinear models and idealized, but yet fairly realistic, nonlinear 3D models based on in vitro experiments with fluid-structure interactions (FSI) and structure-structure interactions (SSI) are introduced and solved by ADINA to perform flow and stress/strain analysis for stenotic arteries with lipid cores. The Navier-Stokes equations are used as the governing equations for the fluid. Hyperelastic Mooney-Rivlin models are used for both the arteries and lipid cores. MRI-based 2D solid models using real patient data, idealized 2D solid models for an eccentric tube with lipid cores, 3D solid and FSI models for tube with asymmetric stenosis and a lipid core are studied. Our results indicate that artery plaque stress/strain distributions are affected considerably by material properties, axial pre-stretch, pressure conditions, lipid core material property, size, position and geometry, and fluid-structure and structure-structure (vessel wall and lipid core) interactions. Sharp angles of lipid cores and thinner plaque cap lead to peak wall stress/strain and may be Hnked to possible plaque cap rupture.
|Title of host publication||Computational Fluid and Solid Mechanics 2003|
|Number of pages||4|
|State||Published - Jun 2 2003|
- Blood flow
- Fluid-structure interaction
- Plaque cap rupture