29 False positives and false negatives in genome scans

Research output: Chapter in Book/Report/Conference proceedingChapter

46 Scopus citations

Abstract

It is emphasized that two types of errors are made in the testing of a hypothesis, false positive (type I) and false negative (type II). Genome-wide scans involving many markers give rise to the problem of multiple testing, which results in an increased number of false positives, thus necessitating a correction in the nominal significance level. While the literature has concentrated reasonably heavily on controlling false positives in genomic scans, the need to control false negatives has been largely neglected. This chapter highlights this need and attempts to strike a balance between the two error types. The need to develop alternative methods for discrimating between false positives and true positives is also stressed.

Original languageEnglish
Title of host publicationAdvances in Genetics
PublisherAcademic Press Inc.
Pages487-498
Number of pages12
ISBN (Print)0120176424, 9780120176427
DOIs
StatePublished - Jan 1 2001

Publication series

NameAdvances in Genetics
Volume42
ISSN (Print)0065-2660

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    Rao, D. C., & Gu, C. (2001). 29 False positives and false negatives in genome scans. In Advances in Genetics (pp. 487-498). (Advances in Genetics; Vol. 42). Academic Press Inc.. https://doi.org/10.1016/s0065-2660(01)42038-4