2.4 Self-assembling biomaterials

J. S. Rudra, S. H. Kelly, J. H. Collier

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


Self-assembly has become a useful way of constructing biomaterials for a variety of applications ranging from cell culture to tissue engineering. Attractive features of self-assembled biomaterials include chemical definition, modularity, stimulus-sensitivity, and the ability to produce complex supramolecular objects from comparatively simple precursors. These aspects also make self-assembly an effective way of bridging the practicality of synthetic materials with the molecular and structural complexity of biologically derived materials. In this chapter, self-assembling strategies are summarized, with particular emphasis on materials employing peptides and proteins as the essential oligomerizing components. Two-dimensional self-assemblies, primarily self-assembled monolayers, are also overviewed. Immune responses to supramolecular biomaterials, advantages that arise from self-assembling approaches, and examples of recent in vivo applications of these materials are additionally discussed.

Original languageEnglish
Title of host publicationComprehensive Biomaterials II
Number of pages23
ISBN (Electronic)9780081006924
ISBN (Print)9780081006917
StatePublished - Jan 1 2017


  • Amphiphiles
  • Biomimetic
  • Coiled coil
  • Collagen
  • Fibrillar
  • Hydrogels
  • Immunogencity
  • Peptide-polymer
  • Regenerative medicine
  • Self-assembled monolayers (SAMs)
  • Self-assembly
  • Tissue engineering
  • Vaccine
  • β-Sheet


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