TY - JOUR
T1 - 2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices
AU - Izumi, Yukitoshi
AU - Clifford, David B.
AU - Zorumski, Charles F.
N1 - Funding Information:
This work was supported in part by the McDonnell Center For Higher Brain Function, NIMH Physician Scientist Award MH00630, and Grants AG05681 and DA05072.
PY - 1991/1/28
Y1 - 1991/1/28
N2 - Rat hippocampal slices were used to examine the effects of 2-amino-3-phosphonopropionate (AP3), an inhibitor of phosphatidylinositol (PI) turnover linked to metabotropic quisqualate receptors, on the development and maintenance of long-term potentiation (LTP) in area CA1. When perfused for 5 min prior to tetanization at concentrations of 100-1000 μM, d,l-AP3 had no effect on baseline synaptic transmission but blocked posttetanic potentiation (PTP) and the induction of LTP. Unlike the N-methyl-d-aspartate (NMDA) antagonists, 2-amino-5-phosphonovalerate (AP5) and MK-801, AP3 eliminated the late phase of LTP when applied immediately after tetanization. These data support the hypothesis that PI turnover is a factor in the expression and maintenance of LTP.
AB - Rat hippocampal slices were used to examine the effects of 2-amino-3-phosphonopropionate (AP3), an inhibitor of phosphatidylinositol (PI) turnover linked to metabotropic quisqualate receptors, on the development and maintenance of long-term potentiation (LTP) in area CA1. When perfused for 5 min prior to tetanization at concentrations of 100-1000 μM, d,l-AP3 had no effect on baseline synaptic transmission but blocked posttetanic potentiation (PTP) and the induction of LTP. Unlike the N-methyl-d-aspartate (NMDA) antagonists, 2-amino-5-phosphonovalerate (AP5) and MK-801, AP3 eliminated the late phase of LTP when applied immediately after tetanization. These data support the hypothesis that PI turnover is a factor in the expression and maintenance of LTP.
KW - 2-Amino-3-phosphonopropionate
KW - Hippocampus
KW - Long-term potentiation
KW - Metabotropic receptor
UR - http://www.scopus.com/inward/record.url?scp=0026035579&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(91)90854-M
DO - 10.1016/0304-3940(91)90854-M
M3 - Article
C2 - 1674119
AN - SCOPUS:0026035579
SN - 0304-3940
VL - 122
SP - 187
EP - 190
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -