γ-Secretase: Proteasome of the membrane?

Raphael Kopan, Ma Xenia G. Ilagan

Research output: Contribution to journalReview article

456 Scopus citations

Abstract

γ-Secretase - a protease that cleaves within the membrane - was first recognized for its role in the production of amyloidogenic Aβ peptides, but was subsequently found to mediate Notch signalling by releasing the Notch-receptor intracellular domain. Many other γ-secretase substrates have recently been identified, which indicates a broader biological function for this unusual protease. Emerging evidence implies that whereas some intracellular cleavage products of γ-secretase function as signalling molecules, others might simply be intermediates that are destined for degradation.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalNature Reviews Molecular Cell Biology
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2004

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