The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates β2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.

Original languageEnglish
Pages (from-to)2440-2444
Number of pages5
JournalCell Cycle
Issue number20
StatePublished - Oct 15 2007


  • Chimaerin
  • Chimerin
  • EGF
  • GAP
  • MAP kinase
  • Rac
  • Rho


Dive into the research topics of 'β2-Chimaerin in cancer signaling: Connecting cell adhesion and MAP kinase activation'. Together they form a unique fingerprint.

Cite this