β2-Chimaerin in cancer signaling: Connecting cell adhesion and MAP kinase activation

Stephen P. Bruinsma; Thomas J. Baranski

doi:10.4161/cc.6.20.4786

β2-Chimaerin in cancer signaling: Connecting cell adhesion and MAP kinase activation

Stephen P. Bruinsma, Thomas J. Baranski

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates β2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.

Original language	English
Pages (from-to)	2440-2444
Number of pages	5
Journal	Cell Cycle
Volume	6
Issue number	20
DOIs	https://doi.org/10.4161/cc.6.20.4786
State	Published - Oct 15 2007

Keywords

Chimaerin
Chimerin
EGF
GAP
MAP kinase
Rac
Rho

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title = "β2-Chimaerin in cancer signaling: Connecting cell adhesion and MAP kinase activation",

abstract = "The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates β2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.",

keywords = "Chimaerin, Chimerin, EGF, GAP, MAP kinase, Rac, Rho",

author = "Bruinsma, {Stephen P.} and Baranski, {Thomas J.}",

year = "2007",

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AU - Baranski, Thomas J.

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Y1 - 2007/10/15

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AB - The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates β2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.

KW - Chimaerin

KW - Chimerin

KW - EGF

KW - GAP

KW - MAP kinase

KW - Rac

KW - Rho

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M3 - Review article

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AN - SCOPUS:35848960556

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SP - 2440

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JF - Cell Cycle

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ER -

β2-Chimaerin in cancer signaling: Connecting cell adhesion and MAP kinase activation

Abstract

Keywords

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