β1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

Sherry A. Castle, Elizabeth A. Owuor, Stephanie H. Thompson, Michelle R. Garnsey, J. Stacey Klutts, Tamara L. Doering, Steven B. Levery

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The Manα1,3(Xylβ1,2)Manα structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylβ1,2- transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

Original languageEnglish
Pages (from-to)1611-1615
Number of pages5
JournalEukaryotic Cell
Volume7
Issue number9
DOIs
StatePublished - Sep 2008

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