β1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

Sherry A. Castle; Elizabeth A. Owuor; Stephanie H. Thompson; Michelle R. Garnsey; J. Stacey Klutts; Tamara L. Doering; Steven B. Levery

doi:10.1128/EC.00458-07

β1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

Sherry A. Castle, Elizabeth A. Owuor, Stephanie H. Thompson, Michelle R. Garnsey, J. Stacey Klutts, Tamara L. Doering, Steven B. Levery

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The Manα1,3(Xylβ1,2)Manα structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylβ1,2- transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

Original language	English
Pages (from-to)	1611-1615
Number of pages	5
Journal	Eukaryotic Cell
Volume	7
Issue number	9
DOIs	https://doi.org/10.1128/EC.00458-07
State	Published - Sep 2008

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title = "β1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids",

abstract = "The Manα1,3(Xylβ1,2)Manα structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylβ1,2- transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.",

author = "Castle, {Sherry A.} and Owuor, {Elizabeth A.} and Thompson, {Stephanie H.} and Garnsey, {Michelle R.} and Klutts, {J. Stacey} and Doering, {Tamara L.} and Levery, {Steven B.}",

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AU - Castle, Sherry A.

AU - Owuor, Elizabeth A.

AU - Thompson, Stephanie H.

AU - Garnsey, Michelle R.

AU - Klutts, J. Stacey

AU - Doering, Tamara L.

AU - Levery, Steven B.

PY - 2008/9

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AB - The Manα1,3(Xylβ1,2)Manα structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylβ1,2- transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

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SN - 1535-9778

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JO - Eukaryotic Cell

JF - Eukaryotic Cell

IS - 9

ER -

β1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

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