TY - JOUR
T1 - β-catenin gets jaded and von Hippel-Lindau is to blame
AU - Berndt, Jason D.
AU - Moon, Randall T.
AU - Major, Michael B.
PY - 2009/3
Y1 - 2009/3
N2 - Numerous studies have pointed to interactions between the tumor suppressor von Hippel-Lindau (VHL) and the oncogenic Wnt-β-catenin signaling cascade; however, the mechanism of this crosstalk has remained elusive. Among other roles, VHL can promote the stabilization of Jade-1. Now, recent findings provide compelling evidence that Jade-1 ubiquitylates β-catenin, leading to its degradation. Thus, the loss of VHL, as seen in clear cell renal cell carcinoma, could lead to tumor formation through β-catenin de-repression.
AB - Numerous studies have pointed to interactions between the tumor suppressor von Hippel-Lindau (VHL) and the oncogenic Wnt-β-catenin signaling cascade; however, the mechanism of this crosstalk has remained elusive. Among other roles, VHL can promote the stabilization of Jade-1. Now, recent findings provide compelling evidence that Jade-1 ubiquitylates β-catenin, leading to its degradation. Thus, the loss of VHL, as seen in clear cell renal cell carcinoma, could lead to tumor formation through β-catenin de-repression.
UR - http://www.scopus.com/inward/record.url?scp=62849095830&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2008.12.002
DO - 10.1016/j.tibs.2008.12.002
M3 - Short survey
C2 - 19217300
AN - SCOPUS:62849095830
SN - 0968-0004
VL - 34
SP - 101
EP - 104
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 3
ER -