β-catenin, cartilage, and osteoarthritis

Qiuqian Wu, Mei Zhu, Randy N. Rosier, Michael J. Zuscik, Regis J. O'Keefe, Di Chen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

45 Scopus citations

Abstract

The early cellular events during the development of osteoarthritis (OA) are accelerated articular chondrocyte maturation and extracellular matrix degradation, which are usually seen in the weight-bearing region of articular cartilage. The results of our recent studies from transgenic OA mouse models indicate that upregulation of β-catenin signaling in articular chondrocytes is most likely responsible for the conversion of normal articular chondrocytes into maturing (arthritic) chondrocytes, which is associated with activation of chondrocyte maturational genes and matrix degradation. Conditional activation of the β-catenin gene in articular chondrocytes leads to an OA-like phenotype. Overexpression of Smurf2, an E3 ubiquitin ligase, also induces an OA-like phenotype through upregulation of β-catenin signaling. In addition, β-catenin upregulation was also found in articular cartilage tissues in patients with OA. These findings indicate that β-catenin plays a central role in articular cartilage function and that activation of β-catenin signaling may represent a pathologic mechanism for OA development.

Original languageEnglish
Title of host publicationSkeletal Biology and Medicine
PublisherBlackwell Publishing Inc.
Pages344-350
Number of pages7
ISBN (Print)9781573317856
DOIs
StatePublished - Mar 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1192
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Articular chondrocyte
  • Conditional activation
  • Osteoarthritis
  • β-catenin

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