β-adrenergic regulation of adenosine 3′,5′-monophosphate concentration in brain microvessels

Timothy J. Herbst, Marcus E. Raichle, James A. Ferrendelli

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Norepinephrine increases the concentration of adenosine 3′,5′-monophosphate (cyclic AMP) in an incubated suspension of brain microvessels. This response can be matched by other drugs that stimulate the β receptors, but the α-adrenergic agonist phenylephrine is without effect; β-adrenergic blockade abolishes the response while αa -adrenergic blockade produces no change. The data support the contention that cerebral capillary function is subject to adrenergic neural control.

Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalScience
Volume204
Issue number4390
DOIs
StatePublished - 1979

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