α(v) Integrins mediate adhesion and migration of breast carcinoma cell lines

Nanette C. Wong, Barbara M. Mueller, Carlos F. Barbas, Pete Ruminski, Vito Quaranta, Emme C.K. Lin, Jeffrey W. Smith

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Integrins with the α(v) subunit are involved in cell adhesion and cellular signaling. Some α(v) integrins have been associated with tumor progression and dissemination. The objective of this study was to assess the contribution of α(v) integrins to the adhesive and migratory behavior of cells derived from breast carcinoma (BCA). The expression and function of α(v) integrins was characterized in three BCA cell lines which exhibit different metastatic potentials. These include MCF-7 cells which metastasize inefficiently, MDA-MB-231 cells, which have a moderate metastatic potential, and MDA-MB-435 cells, which metastasize extensively. Each cell type displays a different repertoire of α(v) integrins on the cell surface. The complement of α(v) integrins on each cell type influences their ability to adhere and migrate. The most striking difference among these cell lines was the expression of the α(v)β3 integrin. The highly metastatic MDA-MB-435 cells express substantial levels of this receptor, whereas MDA-MB-231 and MCF-7 cells do not. The MDA-MB-435 cells showed a greater ability to adhere and to migrate and this functional difference can largely be attributed to the expression of α(v)β3 integrin. This characterization is a first step toward determining the role of α(v) integrins in animal models of BCA metastasis, and lends support to the hypothesis that the α(v)β3 integrin can be a contributing factor in a metastatic disease.

Original languageEnglish
Pages (from-to)50-61
Number of pages12
JournalClinical and Experimental Metastasis
Volume16
Issue number1
DOIs
StatePublished - 1998

Keywords

  • Adhesion
  • Integrin
  • Invasion
  • Metastasis
  • Migration

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