αvβ3-Targeted nanotherapy suppresses inflammatory arthritis in mice

Hui Fang Zhou, Happy W. Chan, Samuel A. Wickline, Gregory M. Lanza, Christine T.N. Pham

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The purpose of this study was to assess whether an alternative treatment approach that targets angiogenesis, delivered through ligand-targeted nanotherapy, would ameliorate inflammatory arthritis. Arthritis was induced using the K/BxN mouse model of inflammatory arthritis. After arthritis was clearly established, mice received three consecutive daily doses of αvβ3-targeted fumagillin nanoparticles. Control groups received no treatment or αvβ3-targeted nanoparticles without drugs. Disease score and paw thickness were measured daily. Mice that received αvβ3-targeted fumagillin nanoparticles showed a significantly lower disease activity score (mean score of 1.4±0.4; P<0.001) and change in ankle thickness (mean increase of 0.17±0.05 mm; P<0.001) 7 d after arthritis induction, whereas the group that received αvβ3-targeted nanoparticles without drugs exhibited a mean arthritic score of 9.0 ± 0.3 and mean change in ankle thickness of 1.01 ± 0.09 mm. Meanwhile, the group that received no treatment showed a mean arthritic score of 9.8 ± 0.5 and mean change in ankle thickness of 1.05 ± 0.10 mm. Synovial tissues from animals treated with targeted fumagillin nanoparticles also showed significant decrease in inflammation and angiogenesis and preserved proteoglycan integrity. Ligand-targeted nanotherapy to deliver antiangiogenic agents may represent an effective way to treat inflammatory arthritis.

Original languageEnglish
Pages (from-to)2978-2985
Number of pages8
JournalFASEB Journal
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2009

Keywords

  • Angiogenesis
  • K/BxN mouse model
  • Perfluorocarbon nanoparticles
  • Systemic drug delivery

Fingerprint Dive into the research topics of 'α<sub>v</sub>β<sub>3</sub>-Targeted nanotherapy suppresses inflammatory arthritis in mice'. Together they form a unique fingerprint.

  • Cite this