TY - JOUR
T1 - (α-aminoacyl)amino-substituted heterocycles and related compounds
AU - Katritzky, Alan R.
AU - El-Gendy, Bahaa El Dien M.
AU - Todadze, Ekaterina
AU - Abdel-Fattah, Ashraf A.A.
PY - 2008/7/18
Y1 - 2008/7/18
N2 - (Chemical Equation Presented) N-Protected-(aminoacyl)benzotriazoles 1a-e,g,i,j,1a′-c′ convert heterocyclic amines of the following series: thiazoles (3a and 3a′), benzothiazoles (3b and 3b′), benzimidazoles (3c and 3c′), thiadiazoles (3d), pyrimidones (9a,b,a′), pyrazoles (11a,b), and pyridines (13a-g, 13d′) under microwave irradiation, into N-substituted amides in yields of 40-98% (average 76%). N-Protected peptidoylbenzotriazoles 6a,b similarly afforded C-terminal N-protected dipeptidoyl amides 7a,b (52-60%).
AB - (Chemical Equation Presented) N-Protected-(aminoacyl)benzotriazoles 1a-e,g,i,j,1a′-c′ convert heterocyclic amines of the following series: thiazoles (3a and 3a′), benzothiazoles (3b and 3b′), benzimidazoles (3c and 3c′), thiadiazoles (3d), pyrimidones (9a,b,a′), pyrazoles (11a,b), and pyridines (13a-g, 13d′) under microwave irradiation, into N-substituted amides in yields of 40-98% (average 76%). N-Protected peptidoylbenzotriazoles 6a,b similarly afforded C-terminal N-protected dipeptidoyl amides 7a,b (52-60%).
UR - http://www.scopus.com/inward/record.url?scp=48249092646&partnerID=8YFLogxK
U2 - 10.1021/jo8007379
DO - 10.1021/jo8007379
M3 - Article
C2 - 18543972
AN - SCOPUS:48249092646
SN - 0022-3263
VL - 73
SP - 5442
EP - 5445
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 14
ER -