Ziwei Chen

2024

Direct measurements of neurosteroid binding to specific sites on GABA_A receptors

Chintala, S. M., Tateiwa, H., Qian, M., Xu, Y., Amtashar, F., Chen, Z. W., Kirkpatrick, C. C., Bracamontes, J., Germann, A. L., Akk, G., Covey, D. F. & Evers, A. S., Nov 2024, In: British Journal of Pharmacology. 181, 21, p. 4229-4244 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

Hoppe, N., Harrison, S., Hwang, S. H., Chen, Z., Karelina, M., Deshpande, I., Suomivuori, C. M., Palicharla, V. R., Berry, S. P., Tschaikner, P., Regele, D., Covey, D. F., Stefan, E., Marks, D. S., Reiter, J. F., Dror, R. O., Evers, A. S., Mukhopadhyay, S. & Manglik, A., Apr 2024, In: Nature Structural and Molecular Biology. 31, 4, p. 667-677 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABA_A receptors

Qian, M., Xu, Y., Shu, H., Chen, Z. W., Wang, L., Zorumski, C., Evers, A. S., Mennerick, S. & Covey, D. F., Nov 13 2024, In: RSC Advances. 14, 49, p. 36352-36369 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Three classes of propofol binding sites on GABA_A receptors

Chen, Z. W., Chintala, S. M., Bracamontes, J., Sugasawa, Y., Pierce, S. R., Varga, B. R., Smith, E. H., Edge, C. J., Franks, N. P., Cheng, W. W. L., Akk, G. & Evers, A. S., Oct 2024, In: Journal of Biological Chemistry. 300, 10, 107778.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors

Tateiwa, H., Chintala, S. M., Chen, Z., Wang, L., Amtashar, F., Bracamontes, J., Germann, A. L., Pierce, S. R., Covey, D. F., Akk, G. & Evers, A. S., Feb 2023, In: Biomolecules. 13, 2, 341.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents

Krishnan, K., Qian, M., Feltes, M., Chen, Z. W., Gale, S., Wang, L., Sugasawa, Y., Reichert, D. E., Schaffer, J. E., Ory, D. S., Evers, A. S. & Covey, D. F., Aug 20 2021, In: ACS Chemical Biology. 16, 8, p. 1493-1507 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2020

Site-specific effects of neurosteroids on gaba_a receptor activation and desensitization

Sugasawa, Y., Cheng, W. W. L., Bracamontes, J. R., Chen, Z. W., Wang, L., Germann, A. L., Pierce, S. R., Senneff, T. C., Krishnan, K., Reichert, D. E., Covey, D. F., Akk, G. & Evers, A. S., Sep 2020, In: eLife. 9, p. 1-32 32 p., e55331.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

2019

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

Budelier, M. M., Cheng, W. W. L., Chen, Z. W., Bracamontes, J. R., Sugasawa, Y., Krishnan, K., Mydock-McGrane, L., Covey, D. F. & Evers, A. S., Feb 2019, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 2, p. 128-136 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Multiple functional neurosteroid binding sites on gabaa receptors

Chen, Z. W., Bracamontes, J. R., Budelier, M. M., Germann, A. L., Shin, D. J., Kathiresan, K., Qian, M. X., Manion, B., Cheng, W. W. L., Reichert, D. E., Akk, G., Covey, D. F. & Evers, A. S., Mar 2019, In: PLoS biology. 17, 3, e3000157.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling

Cheng, W. W. L., Budelier, M. M., Sugasawa, Y., Bergdoll, L., Queralt-Martín, M., Rosencrans, W., Rostovtseva, T. K., Chen, Z. W., Abramson, J., Krishnan, K., Covey, D. F., Whitelegge, J. P. & Evers, A. S., Oct 2019, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 10, p. 1269-1279 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2018

Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC

Cheng, W. W. L., Chen, Z. W., Bracamontes, J. R., Budelier, M. M., Krishnan, K., Shin, D. J., Wang, C., Jiang, X., Covey, D. F., Akk, G. & Evers, A. S., Feb 23 2018, In: Journal of Biological Chemistry. 293, 8, p. 3013-3027 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2017

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins

Budelier, M. M., Cheng, W. W. L., Bergdoll, L., Chen, Z. W., Abramson, J., Krishnan, K., Qian, M., Covey, D. F., Janetka, J. W. & Evers, A. S., Feb 21 2017, In: Analytical Chemistry. 89, 4, p. 2636-2644 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1

Budelier, M. M., Cheng, W. W. L., Bergdoll, L., Chen, Z. W., Janetka, J. W., Abramson, J., Krishnan, K., Mydock-McGrane, L., Covey, D. F., Whitelegge, J. P. & Evers, A. S., Jun 2 2017, In: Journal of Biological Chemistry. 292, 22, p. 9294-9304 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

2015

Mutational analysis of the putative high-affinity propofol binding site in human β3 Homomeric GABAA Receptors

Eaton, M. M., Cao, L. Q., Chen, Z., Franks, N. P., Evers, A. S. & Akk, G., Oct 1 2015, In: Molecular pharmacology. 88, 4, p. 736-745 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2014

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: Potent general anesthetics and photolabeling reagents for GABA_A receptors

Chen, Z. W., Wang, C., Krishnan, K., Manion, B. D., Hastings, R., Bracamontes, J., Taylor, A., Eaton, M. M., Zorumski, C. F., Steinbach, J. H., Akk, G., Mennerick, S., Covey, D. F. & Evers, A. S., Sep 2014, In: Psychopharmacology. 231, 17, p. 3479-3491 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2013

A propofol binding site on mammalian GABA A receptors identified by photolabeling

Yip, G. M. S., Chen, Z. W., Edge, C. J., Smith, E. H., Dickinson, R., Hohenester, E., Townsend, R. R., Fuchs, K., Sieghart, W., Evers, A. S. & Franks, N. P., Nov 2013, In: Nature Chemical Biology. 9, 11, p. 715-720 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

190 Scopus citations

Functional analysis of a migraine-associated TRESK K⁺ channel mutation

Liu, P., Xiao, Z., Ren, F., Guo, Z., Chen, Z., Zhao, H. & Cao, Y. Q., 2013, In: Journal of Neuroscience. 33, 31, p. 12810-12824 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

2012

A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: A mass spectrometric analysis

Chen, Z. W., Chen, L. H., Akentieva, N., Lichti, C. F., Darbandi, R., Hastings, R., Covey, D. F., Reichert, D. E., Townsend, R. R. & Evers, A. S., Feb 2012, In: Electrophoresis. 33, 4, p. 666-674 9 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Deep amino acid sequencing of native brain GABA_A receptors using high-resolution mass spectrometry

Chen, Z. W., Fuchs, K., Sieghart, W., Townsend, R. R. & Evers, A. S., Jan 2012, In: Molecular and Cellular Proteomics. 11, 1

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA_A receptor

Chen, Z. W., Manion, B., Townsend, R. R., Reichert, D. E., Covey, D. F., Steinbach, J. H., Sieghart, W., Fuchs, K. & Evers, A. S., Sep 2012, In: Molecular pharmacology. 82, 3, p. 408-419 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

2011

Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of Δ¹⁶-alphaxalone and identification of a Δ¹⁷⁽²⁰⁾ analogue with potent anesthetic activity

Stastna, E., Krishnan, K., Manion, B. D., Taylor, A., Rath, N. P., Chen, Z. W., Evers, A. S., Zorumski, C. F., Mennerick, S. & Covey, D. F., Jun 9 2011, In: Journal of Medicinal Chemistry. 54, 11, p. 3926-3934 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2010

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABA_A receptors

Evers, A. S., Chen, Z. W., Manion, B. D., Han, M., Jiang, X., Darbandi-Tonkabon, R., Kable, T., Bracamontes, J., Zorumski, C. F., Mennerick, S., Steinbach, J. H. & Covey, D. F., May 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 2, p. 404-413 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Ziwei Chen

Research output

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