Personal profile
Research interests
Our researches are focusing in developing PET probes for imaging neuron receptors, enzymes and transporters for neurodegenerative diseases and other CNS disorders. We have successfully developed PET probes that have the capability of quantifying the density of the Vesicular Acetylcholine Transporter in the brain PET and assessing of the level of phosphodiesterase 10A in the brain. Currently, we are developing probes that will have the capability to measure the accumulation of alpha-synuclein, a reliable hall marker for Parkinson disease in human. We expect to translate these probes into the clinic for the diagnosis and monitoring the therapeutic efficacy of treating Parkinson disease with different therapeutic strategy. In addition, we had successfully developed a sigma-2 receptor PET probe that is currently in translational clinical validation for imaging tumor cell proliferation of breast cancer.
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Collaborations and top research areas from the last five years
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Design, synthesis, and characterization of F-18 sigma-1 receptor radiotracers for Alzheimer disease
Jiang, H., Jadhav, S. B., Soda, A. K., Zhou, W., Chen, H., Xu, S., Qiu, L., Huang, T., Xing, Z., Zhao, L., Lee, J. J., Ni, R., Wong, D. F., Peng, G., Perlmutter, J. S., Benzinger, T. L. S. & Tu, Z., Apr 5 2026, In: European Journal of Medicinal Chemistry. 307, 118647.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery and in vivo evaluation of a fluorine-18 pro-drug tracer for imaging sphingosine-1-phosphate receptor 2 in the brain
Qiu, L., Zhou, W., Chen, H., Jiang, H., Lang, J., Xing, Z., Heady, M., Gropler, R. J., Guglielmetti, C., Perlmutter, J. S. & Tu, Z., Mar 2026, In: Bioorganic and Medicinal Chemistry. 134, 118536.Research output: Contribution to journal › Article › peer-review
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Evaluation of [11C]CS1P1 in Healthy Young and Older Adults
Friedrichsen, K. A., Judge, B. A., Jones, L. A., Rajamanickam, J., Qiu, L., Soda, A. K., Rahmani, F., Benzinger, G. R., King, C. R., Chaney, A. M., Nickels, M. L., Gropler, R. J., Raji, C. A., White, R. L., Perlmutter, J. S., Laforest, R., An, H., Tu, Z., Benzinger, T. L. S. & Brier, M. R., Jan 1 2026, In: American Journal of Neuroradiology. 47, 1, p. 175-183 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Machine learning prediction of multiple distinct high-affinity chemotypes for α-synuclein fibrils
Li, X., Perez, R. M., Tu, Z., Mach, R. H., Giannakoulias, S. & Petersson, E. J., Feb 3 2026, In: Chemical Communications. 62, 9, p. 2922-2926 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PET evaluation of cholinergic system differences in progressive supranuclear palsy and age-matched controls using [18F]VAT
Nai, Y. H., O’Donnell, J. L., Tanenbaum, A., Soda, A. K., Jiang, H., Moerlein, S. M., Norris, S. A., Perlmutter, J. S. & Tu, Z., Jan 1 2026, In: Nuclear Medicine and Biology. 152-153, 109599.Research output: Contribution to journal › Article › peer-review