• 1865 Citations
20002020

Research output per year

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Personal profile

Research interests

Our researches are focusing in developing PET probes for imaging neuron receptors, enzymes and transporters for neurodegenerative diseases and other CNS disorders. We have successfully developed PET probes that have the capability of quantifying the density of the Vesicular Acetylcholine Transporter in the brain PET and assessing of the level of phosphodiesterase 10A in the brain. Currently, we are developing probes that will have the capability to measure the accumulation of alpha-synuclein, a reliable hall marker for Parkinson disease in human. We expect to translate these probes into the clinic for the diagnosis and monitoring the therapeutic efficacy of treating Parkinson disease with different therapeutic strategy. In addition, we had successfully developed a sigma-2 receptor PET probe that is currently in translational clinical validation for imaging tumor cell proliferation of breast cancer.

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Research Output

  • 1865 Citations
  • 91 Article
  • 1 Review article
  • In vivo Characterization of Four 18F-Labeled S1PR1 Tracers for Neuroinflammation

    Liu, H., Luo, Z., Gu, J., Jiang, H., Joshi, S., Shoghi, K., Zhou, Y., Gropler, R. J., Benzinger, T. L. S. & Tu, Z., 2020, (Accepted/In press) In : Molecular Imaging and Biology.

    Research output: Contribution to journalArticle

  • Synthesis and characterization of [125I]TZ6544, a promising radioligand for investigating sphingosine-1-phosphate receptor 2

    Luo, Z., Liang, Q., Liu, H., Sumit, J., Jiang, H., Klein, R. S. & Tu, Z., Sep 1 2020, In : Nuclear Medicine and Biology. 88-89, p. 52-61 10 p.

    Research output: Contribution to journalArticle

  • The impact of dopamine D2-like agonist/antagonist on [18F]VAT PET measurement of VAChT in the brain of nonhuman primates

    Liu, H., Luo, Z., Gu, J., Su, Y., Flores, H., Parsons, S. M., Zhou, Y., Perlmutter, J. S. & Tu, Z., Feb 15 2020, In : European Journal of Pharmaceutical Sciences. 143, 105152.

    Research output: Contribution to journalArticle

  • Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [11C]CS1P1 for human use

    Luo, Z., Gu, J., Dennett, R. C., Gaehle, G. G., Perlmutter, J. S., Chen, D. L., Benzinger, T. L. S. & Tu, Z., Oct 2019, In : Applied Radiation and Isotopes. 152, p. 30-36 7 p.

    Research output: Contribution to journalArticle