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Zhoufeng Chen

Russell D and Mary B Shelden Professor of Anesthesiology, Professor of Psychiatry, Professor of Developmental Biology

    • 10088 Citations
    19952020

    Research output per year

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    Personal profile

    Research interests

    We are interested in studying molecular and cellular mechanisms of itch. Chronic itch or pruritis is a major skin problem, which may result from the disorders of the skin, immune function as well as internal metabolisms. The majority of chronic pruritus is intractable and resistant to conventional anti-histamine therapy. The underlying mechanism of various pruritus is not understood. We are interested in identifying novel itch receptors, signaling molecules and neural circuits, and are using multi-disciplinary approaches including molecular, cellular, biochemical, genetic and electrophysiological approaches to understand how itch is transmitted, its relationship with pain, the skin and immune systems. We are working to identify novel compounds which can block the itch pathway, and developing chronic itch models which mimic different aspects of human pruritus. Once novel anti-itch compounds identified, we hope to bring them into novel anti-pruritus therapeutics.

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    Research Output

    Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors

    Barry, D. M., Liu, X. T., Liu, B., Liu, X. Y., Gao, F., Zeng, X., Liu, J., Yang, Q., Wilhelm, S., Yin, J., Tao, A. & Chen, Z. F., Dec 1 2020, In : Nature communications. 11, 1, 1397.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    Image-Forming Visual Basis of Empathy for Pain in Mice

    Geng, K. W., Du, R., Wei, N., Li, C. L., Wang, Y., Sun, W., Chen, T., Wei, D. Y., Yu, Y., He, T., Luo, W. J., Wang, R. R., Chen, Z. F. & Chen, J., 2020, (Accepted/In press) In : Neuroscience Bulletin.

    Research output: Contribution to journal › Letter

    PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes

    Zhao, J., Munanairi, A., Liu, X. Y., Zhang, J., Hu, L., Hu, M., Bu, D., Liu, L., Xie, Z., Kim, B. S., Yang, Y. & Chen, Z. F., Jan 1 2020, (Accepted/In press) In : Journal of Investigative Dermatology.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Cross-talk between Human Spinal Cord μ-opioid Receptor 1Y Isoform and Gastrin-releasing Peptide Receptor Mediates Opioid-induced Scratching Behavior

    Liu, X. Y., Ginosar, Y., Yazdi, J., Hincker, A. & Chen, Z. F., Aug 1 2019, In : Anesthesiology. 131, 2, p. 381-391 11 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

    Liu, Y., Sun, Y., Zhao, X., Kim, J. Y., Luo, L., Wang, Q., Meng, X., Li, Y., Sui, N., Chen, Z. F., Pan, C., Li, L. & Zhang, Y., Oct 1 2019, In : Neuroscience Bulletin. 35, 5, p. 841-852 12 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations