Yukitoshi Izumi

2024

Endoplasmic reticulum stress, autophagy, neuroinflammation, and sigma 1 receptors as contributors to depression and its treatment

Fujii, C., Zorumski, C. F. & Izumi, Y., Oct 2024, In: Neural Regeneration Research. 19, 10, p. 2202-2211 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment

Izumi, Y., O’Dell, K. A. & Zorumski, C. F., Oct 2024, In: Neural Regeneration Research. 19, 10, p. 2212-2218 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning

Izumi, Y., O'Dell, K. A., Cashikar, A. G., Paul, S., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Jun 2024, In: PloS one. 19, 6 June, e0304481.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2023

Corrigendum: Glaucoma and microglia-induced neuroinflammation(Front. Ophthalmol., (2023), 3, (1132011), 10.3389/fopht.2023.1132011)

Ishikawa, M., Izumi, Y., Sato, K., Sato, T., Zorumski, C. F., Kunikata, H. & Nakazawa, T., 2023, In: Frontiers in Ophthalmology. 3, 1332312.

Research output: Contribution to journal › Comment/debate

Open Access

Glaucoma and microglia-induced neuroinflammation

Ishikawa, M., Izumi, Y., Sato, K., Sato, T., Zorumski, C. F., Kunikata, H. & Nakazawa, T., 2023, In: Frontiers in Ophthalmology. 3, 1132011.

Research output: Contribution to journal › Short survey › peer-review

Open Access

2 Scopus citations

Neurosteroid enantiomers as potentially novel neurotherapeutics

Covey, D. F., Evers, A. S., Izumi, Y., Maguire, J. L., Mennerick, S. J. & Zorumski, C. F., Jun 2023, In: Neuroscience and Biobehavioral Reviews. 149, 105191.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids

Izumi, Y., Reiersen, A. M., Lenze, E. J., Mennerick, S. J. & Zorumski, C. F., Dec 2023, In: Translational psychiatry. 13, 1, 39.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Striatal mGlu₅-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways

Jong, Y. J. I., Izumi, Y., Harmon, S. K., Zorumski, C. F. & ÓMalley, K. L., Aug 2023, In: Journal of Biological Chemistry. 299, 8, 104949.

Research output: Contribution to journal › Article › peer-review

Open Access

The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling

Izumi, Y., O’Dell, K. A. & Zorumski, C. F., Dec 2023, In: Scientific reports. 13, 1, 18005.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

Acrylamide inhibits long-term potentiation and learning involving microglia and pro-inflammatory signaling

Izumi, Y., Fujii, C., O’Dell, K. A. & Zorumski, C. F., Dec 2022, In: Scientific reports. 12, 1, 12429.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus

Izumi, Y., Hsu, F. F., Conway, C. R., Nagele, P., Mennerick, S. J. & Zorumski, C. F., Dec 15 2022, In: Biological Psychiatry. 92, 12, p. 964-972 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

Ishikawa, M., Nakazawa, T., Kunikata, H., Sato, K., Yoshitomi, T., Krishnan, K., Covey, D. F., Zorumski, C. F. & Izumi, Y., Mar 16 2022, In: Frontiers in Pharmacology. 13, 855779.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2021

A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol

Izumi, Y., Cashikar, A. G., Krishnan, K., Paul, S. M., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Dec 8 2021, In: Journal of Neuroscience. 41, 49, p. 10054-10064 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Ethanol, neurosteroids and cellular stress responses: Impact on central nervous system toxicity, inflammation and autophagy

Fujii, C., Zorumski, C. F. & Izumi, Y., May 2021, In: Neuroscience and Biobehavioral Reviews. 124, p. 168-178 11 p.

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Oxysterols modulate the acute effects of ethanol on hippocampal N-methyl-D-aspartate receptors, long-term potentiation, and learning

Izumi, Y., Mennerick, S., Doherty, J. J. & Zorumski, C. F., Apr 1 2021, In: Journal of Pharmacology and Experimental Therapeutics. 377, 1, p. 181-188 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity

Frye, H. E., Izumi, Y., Harris, A. N., Williams, S. B., Trousdale, C. R., Sun, M. Y., Sauerbeck, A. D., Kummer, T. T., Mennerick, S., Zorumski, C. F., Nelson, E. C., Dougherty, J. D. & Morón, J. A., Dec 1 2021, In: Biological Psychiatry. 90, 11, p. 766-780 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA_A receptors in rat glaucoma models

Ishikawa, M., Takaseki, S., Yoshitomi, T., Covey, D. F., Zorumski, C. F. & Izumi, Y., 2021, In: Autophagy. 17, 3, p. 743-760 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2020

Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

Popiolek, M., Izumi, Y., Hopper, A. T., Dai, J., Miller, S., Shu, H. J., Zorumski, C. F. & Mennerick, S., Oct 29 2020, In: Frontiers in Molecular Neuroscience. 13, 568641.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Inhibitors of cellular stress overcome acute effects of ethanol on hippocampal plasticity and learning

Izumi, Y. & Zorumski, C. F., Jul 2020, In: Neurobiology of Disease. 141, 104875.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2019

Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum

Joksimovic, S. M., Izumi, Y., Joksimovic, S. L., Tesic, V., Krishnan, K., Asnake, B., Jevtovic-Todorovic, V., Covey, D. F., Zorumski, C. F. & Todorovic, S. M., May 2019, In: British journal of anaesthesia. 122, 5, p. 643-651 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Temperoammonic stimulation depotentiates schaffer collateral LTP via p38 MAPK downstream of adenosine A1 receptors

Izumi, Y. & Zorumski, C. F., Mar 6 2019, In: Journal of Neuroscience. 39, 10, p. 1783-1792 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2018

Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model

Ishikawa, M., Yoshitomi, T., Covey, D. F., Zorumski, C. F. & Izumi, Y., Dec 1 2018, In: Scientific reports. 8, 1, 12851.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2017

Hippocampal slice preparation in rats acutely suppresses immunoreactivity of microtubule-associated protein (Map2) and glycogen levels without affecting numbers of glia or levels of the glutamate transporter VGlut1

Stein, L. R., Zorumski, C. F. & Izumi, Y., Jul 2017, In: Brain and Behavior. 7, 7, e00736.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Neuregulin and dopamine D4 receptors contribute independently to depotentiation of schaffer collateral LTP by temperoammonic path stimulation

Izumi, Y. & Zorumski, C. F., Jul 1 2017, In: eNeuro. 4, 4, e0176-17.2017.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Pharmacological Aspects of NMDA Receptors, mGluR5, and Endocannabinoids

Izumi, Y. & Zorumski, C. F., Jan 24 2017, Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc., p. 630-638 9 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

The role of T-type calcium channels in the subiculum: to burst or not to burst?

Joksimovic, S. M., Eggan, P., Izumi, Y., Joksimovic, S. L., Tesic, V., Dietz, R. M., Orfila, J. E., DiGruccio, M. R., Herson, P. S., Jevtovic-Todorovic, V., Zorumski, C. F. & Todorovic, S. M., Oct 1 2017, In: Journal of Physiology. 595, 19, p. 6327-6348 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2016

24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

Sun, M. Y., Linsenbardt, A. J., Emnett, C. M., Eisenman, L. N., Izumi, Y., Zorumski, C. F. & Mennerick, S., Apr 1 2016, In: Neuroscientist. 22, 2, p. 132-144 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

71 Scopus citations

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure

Ishikawa, M., Yoshitomi, T., Zorumski, C. F. & Izumi, Y., Sep 22 2016, In: Scientific reports. 6, 33886.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices

Sun, M. Y., Izumi, Y., Benz, A., Zorumski, C. F. & Mennerick, S., Mar 1 2016, In: Journal of neurophysiology. 115, 3, p. 1263-1272 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

GABA and endocannabinoids mediate depotentiation of schaffer collateral synapses induced by stimulation of temperoammonic inputs

Izumi, Y. & Zorumski, C. F., Feb 2016, In: PloS one. 11, 2, e0149034.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Ketamine: NMDA receptors and beyond

Zorumski, C. F., Izumi, Y. & Mennerick, S., Nov 2 2016, In: Journal of Neuroscience. 36, 44, p. 11158-11164 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

152 Scopus citations

Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats

Stein, L. R., O'Dell, K. A., Funatsu, M., Zorumski, C. F. & Izumi, Y., Aug 4 2016, In: Neuroscience. 329, p. 294-305 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model

Ishikawa, M., Yoshitomi, T., Covey, D. F., Zorumski, C. F. & Izumi, Y., Dec 1 2016, In: Neuropharmacology. 111, p. 142-159 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2015

Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis

Izumi, Y., O’Dell, K. A. & Zorumski, C. F., Jun 3 2015, In: Frontiers in Cellular Neuroscience. 9, JULY, 254.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Experimentally Induced Mammalian Models of Glaucoma

Ishikawa, M., Yoshitomi, T., Zorumski, C. F. & Izumi, Y., 2015, In: BioMed Research International. 2015, 281214.

Research output: Contribution to journal › Review article › peer-review

Open Access

51 Scopus citations

Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors

Stein, L. R., Zorumski, C. F., Imai, S. I. & Izumi, Y., Oct 1 2015, In: Brain Research Bulletin. 119, p. 41-51 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Sensitivity of N-Methyl-D-Aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices

Izumi, Y. & Zorumski, C. F., Jan 1 2015, In: Journal of Pharmacology and Experimental Therapeutics. 352, 2, p. 267-273 7 p., A11.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2014

Acute and chronic effects of ethanol on learning-related synaptic plasticity

Zorumski, C. F., Mennerick, S. & Izumi, Y., Feb 2014, In: Alcohol. 48, 1, p. 1-17 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

134 Scopus citations

Expression of nampt in hippocampal and cortical excitatory neurons is critical for cognitive function

Stein, L. R., Wozniak, D. F., Dearborn, J. T., Kubota, S., Apte, R. S., Izumi, Y., Zorumski, C. F. & Imai, S. I., 2014, In: Journal of Neuroscience. 34, 17, p. 5800-5815 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus

Purgert, C. A., Izumi, Y., Jong, Y. J. I., Kumar, V., Zorumski, C. F. & O'Malley, K. L., 2014, In: Journal of Neuroscience. 34, 13, p. 4589-4598 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function

Izumi, Y. & Zorumski, C. F., Nov 2014, In: Neuropharmacology. 86, p. 273-281 9 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Neurosteroids are endogenous neuroprotectants in an ex vivo glaucoma model

Ishikawa, M., Yoshitomi, T., Zorumski, C. F. & Izumi, Y., Dec 1 2014, In: Investigative Ophthalmology and Visual Science. 55, 12, p. 8531-8541 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2013

Ammonia inhibits long-term potentiation via neurosteroid synthesis in hippocampal pyramidal neurons

Izumi, Y., Svrakic, N., O'Dell, K. & Zorumski, C. F., Mar 3 2013, In: Neuroscience. 233, p. 166-173 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Dopamine deficiency underlies learning deficits in neurofibromatosis-1 mice

Diggs-Andrews, K. A., Tokuda, K., Izumi, Y., Zorumski, C. F., Wozniak, D. F. & Gutmann, D. H., Feb 2013, In: Annals of neurology. 73, 2, p. 309-315 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Indistinguishable synaptic pharmacodynamics of the N-Methyl-D-Aspartate receptor channel blockers memantine and ketamine

Emnett, C. M., Eisenman, L. N., Taylor, A. M., Izumi, Y., Zorumski, C. F. & Mennerick, S., Dec 2013, In: Molecular pharmacology. 84, 6, p. 935-947 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Locally-generated acetaldehyde is involved in ethanol-mediated LTP inhibition in the hippocampus

Tokuda, K., Izumi, Y. & Zorumski, C. F., 2013, In: Neuroscience Letters. 537, p. 40-43 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Metaplastic LTP inhibition after LTD induction in CA1 hippocampal slices involves NMDA receptor-mediated neurosteroidogenesis

Izumi, Y., O'dell, K. A. & Zorumski, C. F., Oct 2013, In: Physiological Reports. 1, 5, e00133.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Motivational Disturbances and Effects of L-dopa Administration in Neurofibromatosis-1 Model Mice

Wozniak, D. F., Diggs-Andrews, K. A., Conyers, S., Yuede, C. M., Dearborn, J. T., Brown, J. A., Tokuda, K., Izumi, Y., Zorumski, C. F. & Gutmann, D. H., Jun 10 2013, In: PloS one. 8, 6, e66024.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Neurosteroids, stress and depression: Potential therapeutic opportunities

Zorumski, C. F., Paul, S. M., Izumi, Y., Covey, D. F. & Mennerick, S., Jan 2013, In: Neuroscience and Biobehavioral Reviews. 37, 1, p. 109-122 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

157 Scopus citations

The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-Methyl-D-Aspartate receptors

Paul, S. M., Doherty, J. J., Robichaud, A. J., Belfort, G. M., Chow, B. Y., Hammond, R. S., Crawford, D. C., Linsenbardt, A. J., Shu, H. J., Izumi, Y., Mennerick, S. J. & Zorumski, C. F., 2013, In: Journal of Neuroscience. 33, 44, p. 17290-17300 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

204 Scopus citations

Yukitoshi Izumi

Research output

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