• 1984 Citations

Research output per year

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Personal profile

Research interests

Migraine headache is one of the most common neurovascular disorders and is highly debilitating, poorly understood and difficult to treat. Research in Cao lab focuses on understanding the mechanisms of episodic and chronic migraine from both cellular and systems neuroscience perspectives. We employ a multidisciplinary approach including electrophysiology, time-lapse imaging, anatomical tracing, single neuron profiling as well as mouse genetics and behavioral assays. Current research projects include: 1) To understand how migraine-associated ion channel mutations affect channel biophysics, neuronal excitability, synaptic transmission and the encoding of headache. 2) To study the genetic and epigenetic mechanisms underlying the transition from episodic to chronic migraine. 3) To investigate how the innate and adaptive immune systems modulate the neuronal circuits underlying migraine headache. Through these mechanistic studies, we hope to identify novel molecular and cellular targets for the development of new abortive and prophylactic therapeutics for migraine and other primary headache disorders.

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Research Output

  • 1984 Citations
  • 27 Article
  • 2 Review article
  • 1 Chapter

Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders

Zhang, J., Czerpaniak, K., Huang, L., Liu, X., Cloud, M. E., Unsinger, J., Hotchkiss, R. S., Li, D. & Cao, Y. Q., Jun 1 2020, In : Pain. 161, 6, p. 1381-1398 18 p.

Research output: Contribution to journalArticle

Open Access
  • TRESK K+ channel activity regulates trigeminal nociception and headache

    Guo, Z., Qiu, C. S., Jiang, X., Zhang, J., Li, F., Liu, Q., Dhaka, A. & Cao, Y. Q., Jul 1 2019, In : eNeuro. 6, 4, ENEURO.0236-19.2019.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations

    Deficits in burrowing behaviors are associated with mouse models of neuropathic but not inflammatory pain or migraine

    Shepherd, A. J., Cloud, M. E., Cao, Y. Q. & Mohapatra, D. P., Jun 28 2018, In : Frontiers in Behavioral Neuroscience. 12, 124.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Quantitative Analysis of Mouse Dural Afferent Neurons Expressing TRPM8, VGLUT3, and NF200

    Ren, L., Chang, M. J., Zhang, Z., Dhaka, A., Guo, Z. & Cao, Y. Q., Jan 2018, In : Headache. 58, 1, p. 88-101 14 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Characterization of a mouse model of headache

    Huang, D., Ren, L., Qiu, C. S., Liu, P., Peterson, J., Yanagawa, Y. & Cao, Y. Q., Jun 8 2016, In : Pain. 157, 8, p. 1744-1760 17 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations