Research output per year
Research output per year
- 42 results
Search results
-
2024
A correctable immune niche for epithelial stem cell reprogramming and post-viral lung diseases
Wu, K., Zhang, Y., Yin-DeClue, H., Sun, K., Mao, D., Yang, K., Austin, S. R., Crouch, E. C., Brody, S. L., Byers, D. E., Hoffmann, C. M., Hughes, M. E. & Holtzman, M. J., Sep 17 2024, In: Journal of Clinical Investigation. 134, 18, e183092.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deltex family E3 ligases specifically ubiquitinate the terminal ADP-ribose of poly(ADP-ribosyl)ation
Kelly, M., Dietz, C., Kasson, S., Zhang, Y., Holtzman, M. J. & Kim, I. K., Aug 6 2024, In: Biochemical and Biophysical Research Communications. 720, 150101.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease
Holtzman, M. J., Zhang, Y., Wu, K. & Romero, A. G., Jan 1 2024, In: European Respiratory Review. 33, 171, 230220.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2023
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production
Keeler, S. P., Wu, K., Zhang, Y., Mao, D., Li, M., Iberg, C. A., Austin, S. R., Glaser, S. A., Yantis, J., Podgorny, S., Brody, S. L., Chartock, J. R., Han, Z., Byers, D. E., Romero, A. G. & Holtzman, M. J., Dec 2023, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 325, 6, p. L726-L74Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus
Sadegh, C., Xu, H., Sutin, J., Fatou, B., Gupta, S., Pragana, A., Taylor, M., Kalugin, P. N., Zawadzki, M. E., Alturkistani, O., Shipley, F. B., Dani, N., Fame, R. M., Wurie, Z., Talati, P., Schleicher, R. L., Klein, E. M., Zhang, Y., Holtzman, M. J. & Moore, C. I. & 7 others, , May 17 2023, In: Neuron. 111, 10, p. 1591-1608.e4Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
Fame, R. M., Kalugin, P. N., Petrova, B., Xu, H., Soden, P. A., Shipley, F. B., Dani, N., Grant, B., Pragana, A., Head, J. P., Gupta, S., Shannon, M. L., Chifamba, F. F., Hawks-Mayer, H., Vernon, A., Gao, F., Zhang, Y., Holtzman, M. J., Heiman, M. & Andermann, M. L. & 3 others, , Dec 2023, In: Nature communications. 14, 1, 3720.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Lung Remodeling Regions in Long-Term Coronavirus Disease 2019 Feature Basal Epithelial Cell Reprogramming
Wu, K., Zhang, Y., Austin, S. R., Yin-Declue, H., Byers, D. E., Crouch, E. C. & Holtzman, M. J., Jun 2023, In: American Journal of Pathology. 193, 6, p. 680-689 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2022
Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses
Hazan, G., Eubanks, A., Gierasch, C., Atkinson, J., Fox, C., Hernandez-Leyva, A., Rosen, A. L., Kau, A. L., Agapov, E., Alexander-Brett, J., Steinberg, D., Kelley, D., White, M., Byers, D., Wu, K., Keeler, S. P., Zhang, Y., Koenitzer, J. R., Eiden, E. & Anderson, N. & 2 others, , Mar 15 2022, In: Journal of Immunology. 208, 6, p. 1467-1482 16 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2021
Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease
Wu, K., Kamimoto, K., Zhang, Y., Yang, K., Keeler, S. P., Gerovac, B. J., Agapov, E. V., Austin, S. P., Yantis, J., Gissy, K. A., Byers, D. E., Alexander-Brett, J., Hoffmann, C. M., Wallace, M., Hughes, M. E., Crouch, E. C., Morris, S. A. & Holtzman, M. J., Oct 2021, In: Journal of Clinical Investigation. 131, 19, e149336.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
Xu, H., Fame, R. M., Sadegh, C., Sutin, J., Naranjo, C., Della Syau, S., Cui, J., Shipley, F. B., Vernon, A., Gao, F., Zhang, Y., Holtzman, M. J., Heiman, M., Warf, B. C., Lin, P. Y. & Lehtinen, M. K., Dec 1 2021, In: Nature communications. 12, 1, 447.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
TLR3-activated monocyte-derived dendritic cells trigger progression from acute viral infection to chronic disease in the lung
Wang, X., Wu, K., Keeler, S. P., Mao, D., Agapov, E. V., Zhang, Y. & Holtzman, M. J., Mar 15 2021, In: Journal of Immunology. 206, 6, p. 1297-1314 18 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2020
Group 2 innate lymphoid cells must partner with the myeloid-macrophage lineage for long-term postviral lung disease
Wu, K., Wang, X., Keeler, S. P., Gerovac, B. J., Agapov, E. V., Byers, D. E., Gilfillan, S., Colonna, M., Zhang, Y. & Holtzman, M. J., Aug 15 2020, In: Journal of Immunology. 205, 4, p. 1084-1101 18 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis
Lemeille, S., Paschaki, M., Baas, D., Morlé, L., Duteyrat, J. L., Ait-Lounis, A., Barras, E., Soulavie, F., Jerber, J., Thomas, J., Zhang, Y., Holtzman, M. J., W. Stephen Kistler, S. K., Reith, W. & Durand, B., Sep 18 2020, In: Nucleic acids research. 48, 16, p. 9019-9036 18 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface
Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., Kishkovich, T., Jang, E., Klein, E. M., Goldey, G. J., He, K., Zhang, Y., Holtzman, M. J., Kirchhausen, T., Wyart, C. & Moore, C. I. & 2 others, , Nov 25 2020, In: Neuron. 108, 4, p. 623-639.e10Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
2019
A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to pseudomonas aeruginosa lung infection in mice
Sodhi, C. P., Nguyen, J., Yamaguchi, Y., Werts, A. D., Lu, P., Ladd, M. R., Fulton, W. B., Kovler, M. L., Wang, S., Prindle, T., Zhang, Y., Lazartigues, E. D., Holtzman, M. J., Alcorn, J. F., Hackam, D. J. & Jia, H., Dec 1 2019, In: Journal of Immunology. 203, 11, p. 3000-3012 13 p.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
Author Correction: The choroid plexus is an important circadian clock component (Nature Communications, (2018), 9, 1, (1062), 10.1038/s41467-018-03507-2)
Myung, J., Schmal, C., Hong, S., Tsukizawa, Y., Rose, P., Zhang, Y., Holtzman, M. J., De Schutter, E., Herzel, H., Bordyugov, G. & Takumi, T., Dec 1 2019, In: Nature communications. 10, 1, 5253.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost
Zhang, Y., Mao, D., Keeler, S. P., Wang, X., Wu, K., Gerovac, B. J., Shornick, L. L., Agapov, E. V. & Holtzman, M. J., Apr 15 2019, In: Journal of Immunology. 202, 8, p. 2332-2347 16 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2018
The choroid plexus is an important circadian clock component
Myung, J., Schmal, C., Hong, S., Tsukizawa, Y., Rose, P., Zhang, Y., Holtzman, M. J., De Schutter, E., Herzel, H., Bordyugov, G. & Takumi, T., Dec 1 2018, In: Nature communications. 9, 1, 1062.Research output: Contribution to journal › Article › peer-review
Open Access128 Scopus citations -
2017
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation
Siller, S. S., Sharma, H., Li, S., Yang, J., Zhang, Y., Holtzman, M. J., Winuthayanon, W., Colognato, H., Holdener, B. C., Li, F. Q. & Takemaru, K. I., Dec 2017, In: PLoS genetics. 13, 12, e1007128.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Epithelial Chloride Transport by CFTR Requires TMEM16A
Benedetto, R., Ousingsawat, J., Wanitchakool, P., Zhang, Y., Holtzman, M. J., Amaral, M., Rock, J. R., Schreiber, R. & Kunzelmann, K., Dec 1 2017, In: Scientific reports. 7, 1, 12397.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
Estrogen receptor a is required for oviductal transport of embryos
Li, S., O'Neill, S. R. S., Zhang, Y., Holtzman, M. J., Takemaru, K. I., Korach, K. S. & Winuthayanon, W., Apr 2017, In: FASEB Journal. 31, 4, p. 1595-1607 13 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
2016
Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation
Vindedal, G. F., Thoren, A. E., Jensen, V., Klungland, A., Zhang, Y., Holtzman, M. J., Ottersen, O. P. & Nagelhus, E. A., Dec 1 2016, In: Molecular and Cellular Neuroscience. 77, p. 47-52 6 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression
Olias, P., Etheridge, R. D., Zhang, Y., Holtzman, M. J. & Sibley, L. D., Jul 13 2016, In: Cell Host and Microbe. 20, 1, p. 72-82 11 p.Research output: Contribution to journal › Article › peer-review
Open Access135 Scopus citations -
2015
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection
Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S., Lawson, T. G., Omattage, N. S., Brett, T. J. & Holtzman, M. J., Dec 1 2015, In: Nature immunology. 16, 12, p. 1215-1227 13 p.Research output: Contribution to journal › Article › peer-review
Open Access166 Scopus citations -
Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production
Lun, M. P., Johnson, M. B., Broadbelt, K. G., Watanabe, M., Kang, Y. J., Chau, K. F., Springel, M. W., Malesz, A., Sousa, A. M. M., Pletikos, M., Adelita, T., Calicchio, M. L., Zhang, Y., Holtzman, M. J., Lidov, H. G. W., Sestan, N., Steen, H., Monuki, E. S. & Lehtinen, M. K., 2015, In: Journal of Neuroscience. 35, 12, p. 4903-4916 14 p.Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
STAT1 modification improves therapeutic effects of interferons on lung cancer cells
Chen, J., Zhao, J., Chen, L., Dong, N., Ying, Z., Cai, Z., Ji, D., Zhang, Y., Dong, L., Li, Y., Jiang, L., Holtzman, M. J. & Chen, C., Sep 8 2015, In: Journal of Translational Medicine. 13, 1, 293.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2014
High-throughput screening normalized to biological response: Application to antiviral drug discovery
Patel, D. A., Patel, A. C., Nolan, W. C., Huang, G., Romero, A. G., Charlton, N., Agapov, E., Zhang, Y. & Holtzman, M. J., Jan 2014, In: Journal of Biomolecular Screening. 19, 1, p. 119-130 12 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2013
Correction: Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling (PLoS ONE)
Li, A., Chan, B., Felix, J. C., Xing, Y., Li, M., Brody, S. L., Zhang, Y., Holtzman, M. J., Borok, Z., Li, C. & Minoo, P., May 30 2013, In: PloS one. 8, 5Research output: Contribution to journal › Comment/debate
Open Access -
2012
High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery
Patel, D. A., Patel, A. C., Nolan, W. C., Zhang, Y. & Holtzman, M. J., May 4 2012, In: PloS one. 7, 5, e36594.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection
Page, C., Goicochea, L., Matthews, K., Zhang, Y., Klover, P., Holtzman, M. J., Hennighausen, L. & Frieman, M., Dec 2012, In: Journal of virology. 86, 24, p. 13334-13349 16 p.Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
Molecular heterogeneity in the choroid plexus epithelium: The 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation
Lobas, M. A., Helsper, L., Vernon, C. G., Schreiner, D., Zhang, Y., Holtzman, M. J., Thedens, D. R. & Weiner, J. A., Mar 2012, In: Journal of Neurochemistry. 120, 6, p. 913-927 15 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2011
Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection (Journal of Immunology (2008) 180, (3319-3328))
Shornick, L. P., Wells, A. G., Zhang, Y., Patel, A. C., Huang, G., Takami, K., Sosa, M., Shukla, N. A., Agapov, E. & Holtzmanx, M. J., Sep 1 2011, In: Journal of Immunology. 187, 5, p. 2834 1 p.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Host epithelial-viral interactions as cause and cure for asthma
Holtzman, M. J., Patel, D. A., Zhang, Y. & Patel, A. C., Aug 2011, In: Current Opinion in Immunology. 23, 4, p. 487-494 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access18 Scopus citations -
Hypersusceptibility to respiratory viruses as a shared mechanism for asthma, chronic obstructive pulmonary disease, and cystic fibrosis
Holtzman, M., Patel, D., Kim, H., You, Y. & Zhang, Y., Jun 1 2011, In: American Journal of Respiratory Cell and Molecular Biology. 44, 6, p. 739-742 4 p.Research output: Contribution to journal › Editorial
14 Scopus citations -
Specification of a foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb
Jacquet, B. V., Muthusamy, N., Sommerville, L. J., Xiao, G., Liang, H., Zhang, Y., Holtzman, M. J. & Ghashghaei, H. T., Jun 22 2011, In: Journal of Neuroscience. 31, 25, p. 9368-9382 15 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
2010
Viral and host strategies to take advantage of the innate immune response
Zhang, Y., Hinojosa, M. E., Yoo, N. & Holtzman, M. J., Nov 1 2010, In: American Journal of Respiratory Cell and Molecular Biology. 43, 5, p. 507-510 4 p.Research output: Contribution to journal › Editorial
6 Scopus citations -
2008
Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection
Shornick, L. P., Wells, A. G., Zhang, Y., Patel, A. C., Huang, G., Takami, K., Sosa, M., Shukla, N. A., Agapov, E. & Holtzman, M. J., Mar 1 2008, In: Journal of Immunology. 180, 5, p. 3319-3328 10 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Scopus citations -
2007
A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells
Zhang, Y., Huang, G., Shornick, L. P., Roswit, W. T., Shipley, J. M., Brody, S. L. & Holtzman, M. J., May 2007, In: American Journal of Respiratory Cell and Molecular Biology. 36, 5, p. 515-519 5 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
2005
Acute and chronic airway responses to viral infection: Implications for asthma and chronic obstructive pulmonary disease
Holtzman, M. J., Tyner, J. W., Kim, E. Y., Lo, M. S., Patel, A. C., Shornick, L. P., Agapov, E. & Zhang, Y., 2005, In: Proceedings of the American Thoracic Society. 2, 2, p. 132-140 9 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Defining and adjusting divergent host responses to viral infection
Holtzman, M. J., Kim, E. Y., Lo, M. S., Tyner, J. W., Shornick, L. P., Sumino, K. C. & Zhang, Y., 2005, In: Immunologic Research. 32, 1-3, p. 123-141 19 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment
Zhang, Y., Takami, K., Lo, M. S., Huang, G., Yu, Q., Roswit, W. T. & Holtzman, M. J., Oct 7 2005, In: Journal of Biological Chemistry. 280, 40, p. 34306-34315 10 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2004
"Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease
Holtzman, M. J., Shornick, L. P., Grayson, M. H., Kim, E. Y., Tyner, J. W., Patel, A. C., Agapov, E. & Zhang, Y., Nov 2004, In: Pediatric Infectious Disease Journal. 23, 11 SUPPL., p. S235-S245Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations