Yong Zhang

2023

Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus

Sadegh, C., Xu, H., Sutin, J., Fatou, B., Gupta, S., Pragana, A., Taylor, M., Kalugin, P. N., Zawadzki, M. E., Alturkistani, O., Shipley, F. B., Dani, N., Fame, R. M., Wurie, Z., Talati, P., Schleicher, R. L., Klein, E. M., Zhang, Y., Holtzman, M. J., Moore, C. I., & 7 othersLin, P. Y., Patel, A. B., Warf, B. C., Kimberly, W. T., Steen, H., Andermann, M. L. & Lehtinen, M. K., May 17 2023, In: Neuron. 111, 10, p. 1591-1608.e4

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Lung Remodeling Regions in Long-Term Coronavirus Disease 2019 Feature Basal Epithelial Cell Reprogramming

Wu, K., Zhang, Y., Austin, S. R., Yin-Declue, H., Byers, D. E., Crouch, E. C. & Holtzman, M. J., Jun 2023, In: American Journal of Pathology. 193, 6, p. 680-689 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses

Hazan, G., Eubanks, A., Gierasch, C., Atkinson, J., Fox, C., Hernandez-Leyva, A., Rosen, A. L., Kau, A. L., Agapov, E., Alexander-Brett, J., Steinberg, D., Kelley, D., White, M., Byers, D., Wu, K., Keeler, S. P., Zhang, Y., Koenitzer, J. R., Eiden, E., Anderson, N., & 2 othersHoltzman, M. J. & Haspel, J., Mar 15 2022, In: Journal of Immunology. 208, 6, p. 1467-1482 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2021

Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease

Wu, K., Kamimoto, K., Zhang, Y., Yang, K., Keeler, S. P., Gerovac, B. J., Agapov, E. V., Austin, S. P., Yantis, J., Gissy, K. A., Byers, D. E., Alexander-Brett, J., Hoffmann, C. M., Wallace, M., Hughes, M. E., Crouch, E. C., Morris, S. A. & Holtzman, M. J., Oct 2021, In: Journal of Clinical Investigation. 131, 19, e149336.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Xu, H., Fame, R. M., Sadegh, C., Sutin, J., Naranjo, C., Della Syau, S., Cui, J., Shipley, F. B., Vernon, A., Gao, F., Zhang, Y., Holtzman, M. J., Heiman, M., Warf, B. C., Lin, P. Y. & Lehtinen, M. K., Dec 1 2021, In: Nature communications. 12, 1, 447.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

TLR3-activated monocyte-derived dendritic cells trigger progression from acute viral infection to chronic disease in the lung

Wang, X., Wu, K., Keeler, S. P., Mao, D., Agapov, E. V., Zhang, Y. & Holtzman, M. J., Mar 15 2021, In: Journal of Immunology. 206, 6, p. 1297-1314 18 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2020

Group 2 innate lymphoid cells must partner with the myeloid-macrophage lineage for long-term postviral lung disease

Wu, K., Wang, X., Keeler, S. P., Gerovac, B. J., Agapov, E. V., Byers, D. E., Gilfillan, S., Colonna, M., Zhang, Y. & Holtzman, M. J., Aug 15 2020, In: Journal of Immunology. 205, 4, p. 1084-1101 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis

Lemeille, S., Paschaki, M., Baas, D., Morlé, L., Duteyrat, J. L., Ait-Lounis, A., Barras, E., Soulavie, F., Jerber, J., Thomas, J., Zhang, Y., Holtzman, M. J., W. Stephen Kistler, S. K., Reith, W. & Durand, B., Sep 18 2020, In: Nucleic acids research. 48, 16, p. 9019-9036 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., Kishkovich, T., Jang, E., Klein, E. M., Goldey, G. J., He, K., Zhang, Y., Holtzman, M. J., Kirchhausen, T., Wyart, C., Moore, C. I., & 2 othersAndermann, M. L. & Lehtinen, M. K., Nov 25 2020, In: Neuron. 108, 4, p. 623-639.e10

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

2019

A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to pseudomonas aeruginosa lung infection in mice

Sodhi, C. P., Nguyen, J., Yamaguchi, Y., Werts, A. D., Lu, P., Ladd, M. R., Fulton, W. B., Kovler, M. L., Wang, S., Prindle, T., Zhang, Y., Lazartigues, E. D., Holtzman, M. J., Alcorn, J. F., Hackam, D. J. & Jia, H., Dec 1 2019, In: Journal of Immunology. 203, 11, p. 3000-3012 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Author Correction: The choroid plexus is an important circadian clock component (Nature Communications, (2018), 9, 1, (1062), 10.1038/s41467-018-03507-2)

Myung, J., Schmal, C., Hong, S., Tsukizawa, Y., Rose, P., Zhang, Y., Holtzman, M. J., De Schutter, E., Herzel, H., Bordyugov, G. & Takumi, T., Dec 1 2019, In: Nature communications. 10, 1, 5253.

Research output: Contribution to journal › Comment/debate

Open Access

1 Scopus citations

Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost

Zhang, Y., Mao, D., Keeler, S. P., Wang, X., Wu, K., Gerovac, B. J., Shornick, L. L., Agapov, E. V. & Holtzman, M. J., Apr 15 2019, In: Journal of Immunology. 202, 8, p. 2332-2347 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2018

The choroid plexus is an important circadian clock component

Myung, J., Schmal, C., Hong, S., Tsukizawa, Y., Rose, P., Zhang, Y., Holtzman, M. J., De Schutter, E., Herzel, H., Bordyugov, G. & Takumi, T., Dec 1 2018, In: Nature communications. 9, 1, 1062.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

2017

Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation

Siller, S. S., Sharma, H., Li, S., Yang, J., Zhang, Y., Holtzman, M. J., Winuthayanon, W., Colognato, H., Holdener, B. C., Li, F. Q. & Takemaru, K. I., Dec 2017, In: PLoS genetics. 13, 12, e1007128.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Epithelial Chloride Transport by CFTR Requires TMEM16A

Benedetto, R., Ousingsawat, J., Wanitchakool, P., Zhang, Y., Holtzman, M. J., Amaral, M., Rock, J. R., Schreiber, R. & Kunzelmann, K., Dec 1 2017, In: Scientific reports. 7, 1, 12397.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Scopus citations

Estrogen receptor a is required for oviductal transport of embryos

Li, S., O'Neill, S. R. S., Zhang, Y., Holtzman, M. J., Takemaru, K. I., Korach, K. S. & Winuthayanon, W., Apr 2017, In: FASEB Journal. 31, 4, p. 1595-1607 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2016

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

Vindedal, G. F., Thoren, A. E., Jensen, V., Klungland, A., Zhang, Y., Holtzman, M. J., Ottersen, O. P. & Nagelhus, E. A., Dec 1 2016, In: Molecular and Cellular Neuroscience. 77, p. 47-52 6 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

Olias, P., Etheridge, R. D., Zhang, Y., Holtzman, M. J. & Sibley, L. D., Jul 13 2016, In: Cell Host and Microbe. 20, 1, p. 72-82 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Scopus citations

2015

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S., Lawson, T. G., Omattage, N. S., Brett, T. J. & Holtzman, M. J., Dec 1 2015, In: Nature immunology. 16, 12, p. 1215-1227 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

130 Scopus citations

Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production

Lun, M. P., Johnson, M. B., Broadbelt, K. G., Watanabe, M., Kang, Y. J., Chau, K. F., Springel, M. W., Malesz, A., Sousa, A. M. M., Pletikos, M., Adelita, T., Calicchio, M. L., Zhang, Y., Holtzman, M. J., Lidov, H. G. W., Sestan, N., Steen, H., Monuki, E. S. & Lehtinen, M. K., 2015, In: Journal of Neuroscience. 35, 12, p. 4903-4916 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

STAT1 modification improves therapeutic effects of interferons on lung cancer cells

Chen, J., Zhao, J., Chen, L., Dong, N., Ying, Z., Cai, Z., Ji, D., Zhang, Y., Dong, L., Li, Y., Jiang, L., Holtzman, M. J. & Chen, C., Sep 8 2015, In: Journal of Translational Medicine. 13, 1, 293.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2014

High-throughput screening normalized to biological response: Application to antiviral drug discovery

Patel, D. A., Patel, A. C., Nolan, W. C., Huang, G., Romero, A. G., Charlton, N., Agapov, E., Zhang, Y. & Holtzman, M. J., Jan 2014, In: Journal of Biomolecular Screening. 19, 1, p. 119-130 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2013

Correction: Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling (PLoS ONE)

Li, A., Chan, B., Felix, J. C., Xing, Y., Li, M., Brody, S. L., Zhang, Y., Holtzman, M. J., Borok, Z., Li, C. & Minoo, P., May 30 2013, In: PloS one. 8, 5

Research output: Contribution to journal › Comment/debate

Open Access

2012

High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery

Patel, D. A., Patel, A. C., Nolan, W. C., Zhang, Y. & Holtzman, M. J., May 4 2012, In: PloS one. 7, 5, e36594.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection

Page, C., Goicochea, L., Matthews, K., Zhang, Y., Klover, P., Holtzman, M. J., Hennighausen, L. & Frieman, M., Dec 2012, In: Journal of virology. 86, 24, p. 13334-13349 16 p.

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Molecular heterogeneity in the choroid plexus epithelium: The 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation

Lobas, M. A., Helsper, L., Vernon, C. G., Schreiner, D., Zhang, Y., Holtzman, M. J., Thedens, D. R. & Weiner, J. A., Mar 2012, In: Journal of Neurochemistry. 120, 6, p. 913-927 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2011

Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection (Journal of Immunology (2008) 180, (3319-3328))

Shornick, L. P., Wells, A. G., Zhang, Y., Patel, A. C., Huang, G., Takami, K., Sosa, M., Shukla, N. A., Agapov, E. & Holtzmanx, M. J., Sep 1 2011, In: Journal of Immunology. 187, 5, p. 2834 1 p.

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Host epithelial-viral interactions as cause and cure for asthma

Holtzman, M. J., Patel, D. A., Zhang, Y. & Patel, A. C., Aug 2011, In: Current Opinion in Immunology. 23, 4, p. 487-494 8 p.

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Hypersusceptibility to respiratory viruses as a shared mechanism for asthma, chronic obstructive pulmonary disease, and cystic fibrosis

Holtzman, M., Patel, D., Kim, H., You, Y. & Zhang, Y., Jun 1 2011, In: American Journal of Respiratory Cell and Molecular Biology. 44, 6, p. 739-742 4 p.

Research output: Contribution to journal › Editorial

13 Scopus citations

Specification of a foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb

Jacquet, B. V., Muthusamy, N., Sommerville, L. J., Xiao, G., Liang, H., Zhang, Y., Holtzman, M. J. & Ghashghaei, H. T., Jun 22 2011, In: Journal of Neuroscience. 31, 25, p. 9368-9382 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2010

Viral and host strategies to take advantage of the innate immune response

Zhang, Y., Hinojosa, M. E., Yoo, N. & Holtzman, M. J., Nov 1 2010, In: American Journal of Respiratory Cell and Molecular Biology. 43, 5, p. 507-510 4 p.

Research output: Contribution to journal › Editorial

6 Scopus citations

2008

Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection

Shornick, L. P., Wells, A. G., Zhang, Y., Patel, A. C., Huang, G., Takami, K., Sosa, M., Shukla, N. A., Agapov, E. & Holtzman, M. J., Mar 1 2008, In: Journal of Immunology. 180, 5, p. 3319-3328 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

2007

A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells

Zhang, Y., Huang, G., Shornick, L. P., Roswit, W. T., Shipley, J. M., Brody, S. L. & Holtzman, M. J., May 2007, In: American Journal of Respiratory Cell and Molecular Biology. 36, 5, p. 515-519 5 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

2005

Acute and chronic airway responses to viral infection: Implications for asthma and chronic obstructive pulmonary disease

Holtzman, M. J., Tyner, J. W., Kim, E. Y., Lo, M. S., Patel, A. C., Shornick, L. P., Agapov, E. & Zhang, Y., 2005, In: Proceedings of the American Thoracic Society. 2, 2, p. 132-140 9 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Defining and adjusting divergent host responses to viral infection

Holtzman, M. J., Kim, E. Y., Lo, M. S., Tyner, J. W., Shornick, L. P., Sumino, K. C. & Zhang, Y., 2005, In: Immunologic Research. 32, 1-3, p. 123-141 19 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment

Zhang, Y., Takami, K., Lo, M. S., Huang, G., Yu, Q., Roswit, W. T. & Holtzman, M. J., Oct 7 2005, In: Journal of Biological Chemistry. 280, 40, p. 34306-34315 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2004

"Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease

Holtzman, M. J., Shornick, L. P., Grayson, M. H., Kim, E. Y., Tyner, J. W., Patel, A. C., Agapov, E. & Zhang, Y., Nov 2004, In: Pediatric Infectious Disease Journal. 23, 11 SUPPL., p. S235-S245

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Yong Zhang

Research output

Search results