Research output per year
Research output per year
Personal profile
Research interests
Axonal degeneration as well as the soma degeneration is a component of many neurological diseases. Through studies of Nmnat transgenic mice which has axonal protective phenotype after injury, we found that enzymatic activity of Nmnat is essential to delay axonal degeneration both in-vitro and in-vivo. I am interested in the molecular mechanism of axonal protection/degeneration and try to find a way to delay axon degeneration in various neurological diseases.
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Collaborations and top research areas from the last five years
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Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging
Qi, N., Franczyk, M. P., Yamaguchi, S., Kojima, D., Hayashi, K., Satoh, A., Ogiso, N., Kanda, T., Sasaki, Y., Finck, B. N., DeBosch, B. J. & Yoshino, J., Jul 2024, In: American Journal of Physiology - Endocrinology and Metabolism. 327, 1, p. E81-E88Research output: Contribution to journal › Article › peer-review
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Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function
Lee, T. J., Sasaki, Y., Ruzycki, P. A., Ban, N., Lin, J. B., Wu, H. T., Santeford, A. & Apte, R. S., 2024, In: JCI Insight. 9, 4, e173707.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion
Terao, R., Lee, T. J., Colasanti, J., Pfeifer, C. W., Lin, J. B., Santeford, A., Hase, K., Yamaguchi, S., Du, D., Sohn, B. S., Sasaki, Y., Yoshida, M. & Apte, R. S., May 28 2024, In: Cell Reports. 43, 5, 114102.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
NAD+ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction
Malique, A., Sun, S., Chandwe, K., Amadi, B., Haritunians, T., Jain, U., Muegge, B. D., Frein, J., Sasaki, Y., Foster, A., Storer, C. E., Mengesha, E., Kern, J., McGovern, D. P. B., Head, R. D., Kelly, P. & Liu, T. C., 2024, In: Science translational medicine. 16, 728, 4145.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism
Yamaguchi, S., Kojima, D., Iqbal, T., Kosugi, S., Franczyk, M. P., Qi, N., Sasaki, Y., Yaku, K., Kaneko, K., Kinouchi, K., Itoh, H., Hayashi, K., Nakagawa, T. & Yoshino, J., Sep 24 2023, In: Biochemical and Biophysical Research Communications. 674, p. 162-169 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations