• 5336 Citations
1994 …2020

Research output per year

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Personal profile

Research interests

Axonal degeneration as well as the soma degeneration is a component of many neurological diseases. Through studies of Nmnat transgenic mice which has axonal protective phenotype after injury, we found that enzymatic activity of Nmnat is essential to delay axonal degeneration both in-vitro and in-vivo. I am interested in the molecular mechanism of axonal protection/degeneration and try to find a way to delay axon degeneration in various neurological diseases.

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Research Output

  • 5336 Citations
  • 52 Article
  • 2 Comment/debate
  • 1 Letter
  • 1 Review article

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

Sasaki, Y., Engber, T. M., Hughes, R. O., Figley, M. D., Wu, T., Bosanac, T., Devraj, R., Milbrandt, J., Krauss, R. & DiAntonio, A., Jul 2020, In : Experimental Neurology. 329, 113252.

Research output: Contribution to journalArticle

  • 3 Scopus citations

    Viral Transduction of DRG Neurons

    Sasaki, Y., Jan 1 2020, In : Methods in molecular biology (Clifton, N.J.). 2143, p. 55-62 8 p.

    Research output: Contribution to journalArticle

  • Adipose tissue NAD+ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice

    Yamaguchi, S., Franczyk, M. P., Chondronikola, M., Qi, N., Gunawardana, S. C., Stromsdorfer, K. L., Porter, L. C., Wozniak, D. F., Sasaki, Y., Rensing, N., Wong, M., Piston, D. W., Klein, S. & Yoshino, J., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23822-23828 7 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter (Nature Metabolism, (2019), 1, 1, (47-57), 10.1038/s42255-018-0009-4)

    Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E. & Imai, S. I., Jul 1 2019, In : Nature Metabolism. 1, 7, 1 p.

    Research output: Contribution to journalComment/debate

  • Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice

    Yoshida, M., Satoh, A., Lin, J. B., Mills, K. F., Sasaki, Y., Rensing, N., Wong, M., Apte, R. S. & Imai, S. I., Aug 6 2019, In : Cell metabolism. 30, 2, p. 329-342.e5

    Research output: Contribution to journalArticle

  • 42 Scopus citations