Personal profile
Research interests
My research interests focus on three areas:
1) Identification of new biomarkers using liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomics
2) Development and implementation of LC-MS/MS clinical laboratory tests
3) Development and validation of LC-MS/MS methods for quantification of biomarkers and drugs to support clinical trials
I have discovered long chain ceramides as biomarkers for diabetic cardiovascular disease and bile acid markers for NPC disease. I have developed and implemented an oxysterol diagnostic blood test for NPC disease, and 24-hydroxycholesterol and 2-hydroxypropyl-ß-cyclodextrin assays for a Phase 1 clinical trial. One of current efforts is to develop diagnostic test and newborn screening method for NPC disease using the bile acid markers.
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Five-year analysis of efficacy and safety of a bidirectional AAV gene therapy in Tay-Sachs sheep
Taghian, T., Gallagher, J., Bertrand, S., Baker, W. C., Mercado, K. L., Benatti, H. R., Hall, E., Lopez, Y., McElroy, A., McCarthy, J. T., Pulaparthi, S., Fernau, D., Mather, S., Esteves, S., Diffie, E., Gross, A., Lahey, H. G., Jiang, X., Parsley, E. & Gately, R. & 17 others, , Jan 2 2026, In: Journal of Clinical Investigation. 136, 1, p. 1-17 17 p., e182942.Research output: Contribution to journal › Article › peer-review
Open Access -
ASO Visual Abstract: Plasma Ceramide C24:0/C16:0 Ratio is Associated with Improved Survival in Patients with Pancreatic Ductal Adenocarcinoma
Mitchell, J. D., Panni, U., Fergestrom, N., Toriola, A. T., Nywening, T. M., Goedegebuure, S. P., Jiang, X., Mudd, J. L., Cao, Y., Ippolito, J., Fields, R. C., Hawkins, W. G. & Peterson, L. R., Jan 1 2025, In: Annals of Surgical Oncology. 32, 1, p. 537-538 2 p.Research output: Contribution to journal › Article › peer-review
-
Cerebrospinal Fluid Flow Enhancement (CFE) Increases the Spatial Distribution of Methotrexate after Intracerebroventricular Administration in a Sheep Model
Benatti, H. R., Taghian, T., Mihalek, O., Nath, S., Gallagher, J., McElroy, A., Hall, E. F., Daci, R., Yingling, N. K., Baker, W. C., Tuominen, S., Bierfeldt, L., Jiang, X., Gray-Edwards, H. L. & Sirianni, R. W., Jul 7 2025, In: Molecular Pharmaceutics. 22, 7, p. 3654-3665 12 p.Research output: Contribution to journal › Article › peer-review
-
Clinical and biochemical abnormalities in a feline model of GM2 activator deficiency
Beecy, S. J., Gross, A. L., Maguire, A. S., Hoffman, L. M. K., Diffie, E. B., Cuddon, P., Kell, P., Jiang, X., Gray-Edwards, H. L. & Martin, D. R., Jan 2025, In: Molecular genetics and metabolism. 144, 1, 108615.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
Dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis: a phase 1/2 trial
Eichler, F., Cataltepe, O. I., Daci, R., Puri, A. S., Taghian, T., Jiang, X., Shazeeb, M. S., Kuhn, A., Hader, A., Celik, H., Vardar, Z., Lewis, C. J., Artinian, R., Nagy, A., Vachha, B., Thompson, R., Gallagher, T., Bateman, S., Parzych, J. & Spanakis, S. G. & 16 others, , Sep 2025, In: Nature medicine. 31, 9, p. 2927-2935 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations