Personal profile

Research interests

My research interests focus on three areas:

1) Identification of new biomarkers using liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomics

2) Development and implementation of LC-MS/MS clinical laboratory tests

3) Development and validation of LC-MS/MS methods for quantification of biomarkers and drugs to support clinical trials

I have discovered long chain ceramides as biomarkers for diabetic cardiovascular disease and bile acid markers for NPC disease. I have developed and implemented an oxysterol diagnostic blood test for NPC disease, and 24-hydroxycholesterol and 2-hydroxypropyl-ß-cyclodextrin assays for a Phase 1 clinical trial. One of current efforts is to develop diagnostic test and newborn screening method for NPC disease using the bile acid markers.


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Collaborations and top research areas from the last five years

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