• 182 Citations
20072019

Research output per year

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Personal profile

Research interests

My primary research interest is to understand the molecular mechanisms of dietary fat digestion by pancreatic lipases in young children to improve fat digestion for better growth and development. My secondary research interest is to define the role of proteotoxicity in the pathophysiology of chronic pancreatitis using mutant misfolded pancreatic lipases as study model for finding potential novel therapies.

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Research Output

  • 182 Citations
  • 13 Article
  • 1 Comment/debate

Protease-Sensitive Pancreatic Lipase Variants Are Associated with Early Onset Chronic Pancreatitis

Lasher, D., Szabó, A., Masamune, A., Chen, J. M., Xiao, X., Whitcomb, D. C., Barmada, M. M., Ewers, M., Ruffert, C., Paliwal, S., Issarapu, P., Bhaskar, S., Mani, K. R., Chandak, G. R., Laumen, H., Masson, E., Kume, K., Hamada, S., Nakano, E., Seltsam, K. & 9 others, Bugert, P., Müller, T., Groneberg, D. A., Shimosegawa, T., Rosendahl, J., Férec, C., Lowe, M. E., Witt, H. & Sahin-Tóth, M., Jun 1 2019, In : American Journal of Gastroenterology. 114, 6, p. 974-983 10 p.

Research output: Contribution to journalArticle

  • 7 Scopus citations

    Erratum: A carboxyl ester lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis (Journal of Biological Chemistry (2016) 291 (23224-23236) DOI: 10.1074/jbc.M116.734384)

    Xiao, X., Jones, G., Sevilla, W. A., Stolz, D. B., Magee, K. E., Haughney, M., Mukherjee, A., Wang, Y. & Lowe, M. E., May 12 2017, In : Journal of Biological Chemistry. 292, 19, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • 4 Scopus citations

    A Carboxyl Ester Lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis

    Xiao, X., Jones, G., Sevilla, W. A., Stolz, D. B., Magee, K. E., Haughney, M., Mukherjee, A., Wang, Y. & Lowe, M. E., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 23224-23236 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 15 Scopus citations

    A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding

    Szabó, A., Xiao, X., Haughney, M., Spector, A., Sahin-Tóth, M. & Lowe, M. E., Jul 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 7, p. 1372-1379 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 13 Scopus citations
    Open Access
  • 5 Scopus citations