Research output per year
Research output per year
Personal profile
Research interests
My primary research interest is to understand the molecular mechanisms of dietary fat digestion by pancreatic lipases in young children to improve fat digestion for better growth and development. My secondary research interest is to define the role of proteotoxicity in the pathophysiology of chronic pancreatitis using mutant misfolded pancreatic lipases as study model for finding potential novel therapies.
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Collaborations and top research areas from the last five years
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Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas
Brekke, R. S., Gravdal, A., El Jellas, K., Curry, G. E., Lin, J., Wilhelm, S. J., Steine, S. J., Mas, E., Johansson, S., Lowe, M. E., Johansson, B. B., Xiao, X., Fjeld, K. & Molven, A., Jun 1 2024, In: Human molecular genetics. 33, 11, p. 1001-1014 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort
Cassidy, B. M., Jiang, F., Lin, J., Chen, J. M., Curry, G. E., Ma, G. X., Wilhelm, S. J., Deng, S. J., Zhu, G., Liao, Z., Lowe, M. E., Xiao, X. & Zou, W. B., Jun 2024, In: Pancreatology. 24, 4, p. 511-521 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Characterization of novel PNLIP variants in congenital pancreatic lipase deficiency
Lin, J., Matiwala, N., Curry, G. E., Wilhelm, S. J., Cassidy, B. M., Lowe, M. E. & Xiao, X., Dec 2023, In: Pancreatology. 23, 8, p. 1036-1040 5 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis
Zhu, G., Wilhelm, S. J., George, L. G., Cassidy, B. M., Zino, S., Luke, C. J., Hanna, M., Stone, S., Phan, N., Matiwala, N., Ballentine, S. J., Lowe, M. & Xiao, X., Jul 1 2023, In: Gut. 72, 7, p. 1340-1354 15 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice
Fjeld, K., Gravdal, A., Brekke, R. S., Alam, J., Wilhelm, S. J., El Jellas, K., Pettersen, H. N., Lin, J., Solheim, M. H., Steine, S. J., Johansson, B. B., Njølstad, P. R., Verbeke, C. S., Xiao, X., Lowe, M. E. & Molven, A., Dec 2022, In: Pancreatology. 22, 8, p. 1099-1111 13 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations