Xiaoying Chen

2024

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba-Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., Gate, D., Golden, L. R., Heinecke, J. W., Herz, J., Huang, Y., Iadecola, C., Johnson, L. A., Kanekiyo, T., Karch, C. M. & Khvorova, A. & 40 others, Koppes-den Hertog, S. J., Lamb, B. T., Lawler, P. E., Guen, Y. L., Litvinchuk, A., Liu, C. C., Mahinrad, S., Marcora, E., Marino, C., Michaelson, D. M., Miller, J. J., Morganti, J. M., Narayan, P. S., Naslavsky, M. S., Oosthoek, M., Ramachandran, K. V., Ramakrishnan, A., Raulin, A. C., Robert, A., Saleh, R. N. M., Sexton, C., Shah, N., Shue, F., Sible, I. J., Soranno, A., Strickland, M. R., Tcw, J., Thierry, M., Tsai, L. H., Tuckey, R. A., Ulrich, J. D., van der Kant, R., Wang, N., Wellington, C. L., Weninger, S. C., Yassine, H. N., Zhao, N., Bu, G., Goate, A. M. & Holtzman, D. M., Sep 2024, In: Alzheimer's and Dementia. 20, 9, p. 6590-6605 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Carling, G. K., Fan, L., Foxe, N. R., Norman, K., Wong, M. Y., Zhu, D., Corona, C., Razzoli, A., Yu, F., Yarahmady, A., Ye, P., Chen, H., Huang, Y., Amin, S., Sereda, R., Lopez-Lee, C., Zacharioudakis, E., Chen, X., Xu, J. & Cheng, F. & 10 others, Gavathiotis, E., Cuervo, A. M., Holtzman, D. M., Mok, S. A., Sinha, S. C., Sidoli, S., Ratan, R. R., Luo, W., Gong, S. & Gan, L., Dec 4 2024, In: Neuron. 112, 23, p. 3877-3896.e8

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Correction to: Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy (Nature, (2023), 615, 7953, (668-677), 10.1038/s41586-023-05788-0)

Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D. & Holtzman, D. M., Oct 31 2024, In: Nature. 634, 8036, p. E15

Research output: Contribution to journal › Comment/debate

Open Access

2023

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D. & Holtzman, D. M., Mar 23 2023, In: Nature. 615, 7953, p. 668-677 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

233 Scopus citations

2022

Emerging roles of innate and adaptive immunity in Alzheimer's disease

Chen, X. & Holtzman, D. M., Dec 13 2022, In: Immunity. 55, 12, p. 2236-2254 19 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

116 Scopus citations

Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning

Chen, X., Du, Y., Broussard, G. J., Kislin, M., Yuede, C. M., Zhang, S., Dietmann, S., Gabel, H., Zhao, G., Wang, S. S. H., Zhang, X. & Bonni, A., May 26 2022, In: Nature. 605, 7911, p. 722-727 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2021

Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2

Chen, X., Han, X., Blanchi, B., Guan, W., Ge, W., Yu, Y. C. & Sun, Y. E., Aug 2021, In: Protein and Cell. 12, 8, p. 639-652 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2020

Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway

Smith, S. E., Chen, X., Brier, L. M., Bumstead, J. R., Rensing, N. R., Ringel, A. E., Shin, H., Oldenborg, A., Crowley, J. R., Bice, A. R., Dikranian, K., Ippolito, J. E., Haigis, M. C., Papouin, T., Zhao, G., Wong, M., Culver, J. P. & Bonni, A., Dec 2020, In: Nature communications. 11, 1, 6164.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Robust principal component analysis for accurate outlier sample detection in RNA-Seq data

Chen, X., Zhang, B., Wang, T., Wang, T., Bonni, A. & Zhao, G., Jun 29 2020, In: BMC bioinformatics. 21, 1, 269.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

2019

The transcriptional regulator snon promotes the proliferation of cerebellar granule neuron precursors in the postnatal mouse brain

Chen, X., Chanda, A., Ikeuchi, Y., Zhang, X., Goodman, J. V., Reddy, N. C., Majidi, S. P., Wu, D. Y., Smith, S. E., Godec, A., Oldenborg, A., Gabel, H. W., Zhao, G., Bonni, S. & Bonni, A., Jan 2 2019, In: Journal of Neuroscience. 39, 1, p. 44-62 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2017

Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys

Chen, Y., Yu, J., Niu, Y., Qin, D., Liu, H., Li, G., Hu, Y., Wang, J., Lu, Y., Kang, Y., Jiang, Y., Wu, K., Li, S., Wei, J., He, J., Wang, J., Liu, X., Luo, Y., Si, C. & Bai, R. & 17 others, Zhang, K., Liu, J., Huang, S., Chen, Z., Wang, S., Chen, X., Bao, X., Zhang, Q., Li, F., Geng, R., Liang, A., Shen, D., Jiang, T., Hu, X., Ma, Y., Ji, W. & Sun, Y. E., May 18 2017, In: Cell. 169, 5, p. 945-955.e10

Research output: Contribution to journal › Article › peer-review

Open Access

159 Scopus citations

2016

Coupled electrophysiological recording and single cell transcriptome analyses revealed molecular mechanisms underlying neuronal maturation

Chen, X., Zhang, K., Zhou, L., Gao, X., Wang, J., Yao, Y., He, F., Luo, Y., Yu, Y., Li, S., Cheng, L. & Sun, Y. E., Mar 1 2016, In: Protein and Cell. 7, 3, p. 175-186 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2014

TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys

Liu, H., Chen, Y., Niu, Y., Zhang, K., Kang, Y., Ge, W., Liu, X., Zhao, E., Wang, C., Lin, S., Jing, B., Si, C., Lin, Q., Chen, X., Lin, H., Pu, X., Wang, Y., Qin, B., Wang, F. & Wang, H. & 12 others, Si, W., Zhou, J., Tan, T., Li, T., Ji, S., Xue, Z., Luo, Y., Cheng, L., Zhou, Q., Li, S., Sun, Y. E. & Ji, W., Mar 6 2014, In: Cell Stem Cell. 14, 3, p. 323-328 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

171 Scopus citations

Xiaoying Chen

Research output

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