Research output per year
Research output per year
Personal profile
Research interests
Both immune system and central nervous system continuously surveil the environment and make on-demand adjustments to maintain our body in healthy states. The goal of my research focuses on understanding the mechanism governing immune response in healthy and diseased brain; how brain and immune systems communicate in learning, aging and neurodegenerative disease at cellular and system level; and how different cellular mechanisms can be targeted to prevent neurodegeneration.
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Collaborations and top research areas from the last five years
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Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D. & Holtzman, D. M., Mar 23 2023, In: Nature. 615, 7953, p. 668-677 10 p.Research output: Contribution to journal › Article › peer-review
Open Access193 Scopus citations -
Emerging roles of innate and adaptive immunity in Alzheimer's disease
Chen, X. & Holtzman, D. M., Dec 13 2022, In: Immunity. 55, 12, p. 2236-2254 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access94 Scopus citations -
Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning
Chen, X., Du, Y., Broussard, G. J., Kislin, M., Yuede, C. M., Zhang, S., Dietmann, S., Gabel, H., Zhao, G., Wang, S. S. H., Zhang, X. & Bonni, A., May 26 2022, In: Nature. 605, 7911, p. 722-727 6 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2
Chen, X., Han, X., Blanchi, B., Guan, W., Ge, W., Yu, Y. C. & Sun, Y. E., Aug 2021, In: Protein and Cell. 12, 8, p. 639-652 14 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway
Smith, S. E., Chen, X., Brier, L. M., Bumstead, J. R., Rensing, N. R., Ringel, A. E., Shin, H., Oldenborg, A., Crowley, J. R., Bice, A. R., Dikranian, K., Ippolito, J. E., Haigis, M. C., Papouin, T., Zhao, G., Wong, M., Culver, J. P. & Bonni, A., Dec 2020, In: Nature communications. 11, 1, 6164.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations