Xiaoming Xia

Li, P., Halabi, C. M., Stewart, R., Butler, A., Brown, B., Xia, X., Santi, C., England, S., Ferreira, J., Mecham, R. P. & Salkoff, L., Oct 1 2019, In: Journal of Physiology. 597, 20, p. 5093-5108 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice

Reijntjes, D. O. J., Lee, J. H., Park, S., Schubert, N. M. A., van Tuinen, M., Vijayakumar, S., Jones, T. A., Jones, S. M., Gratton, M. A., Xia, X. M., Yamoah, E. N. & Pyott, S. J., Dec 1 2019, In: Scientific reports. 9, 1, 2573.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2018

BK channel inhibition by strong extracellular acidification

Zhou, Y., Xia, X. M. & Lingle, C. J., Jul 2 2018, In: eLife. 7, e38060.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Regulatory γ1 subunits defy symmetry in functional modulation of BK channels

Gonzalez-Perez, V., Johny, M. B., Xia, X. M. & Lingle, C. J., Oct 2 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 9923-9928 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2017

Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells

Yang, C., Gonzalez-Perez, V., Mukaibo, T., Melvin, J. E., Xia, X. M. & Lingle, C. J., May 2 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 18, p. E3739-E3747

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2016

Cardiac Slo2.1 is required for volatile anesthetic stimulation of K+ transport and anesthetic preconditioning

Wojtovich, A. P., Smith, C. O., Urciuoli, W. R., Wang, Y. T., Xia, X. M., Brookes, P. S. & Nehrke, K., May 1 2016, In: Anesthesiology. 124, 5, p. 1065-1076 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2015

Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications

Zhou, Y., Xia, X. M. & Lingle, C. J., Apr 21 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 16, p. 5237-5242 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Knockout of Slo2.2 enhances itch, abolishes K_Na current, and increases action potential firing frequency in DRG neurons

Martinez-Espinosa, P. L., Wu, J., Yang, C., Gonzalez-Perez, V., Zhou, H., Liang, H., Xia, X. M. & Lingle, C. J., Nov 11 2015, In: eLife. 4, NOVEMBER2015, e10013.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility

Zeng, X. H., Yang, C., Xia, X. M., Liua, M. & Lingle, C. J., Feb 24 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. 2599-2604 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating

Gonzalez-Perez, V., Xia, X. M. & Lingle, C. J., Sep 21 2015, In: Nature communications. 6, 8341.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2014

Functional regulation of BK potassium channels by γ1 auxiliary subunits

Gonzalez-Perez, V., Xia, X. M. & Lingle, C. J., Apr 1 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 13, p. 4868-4873 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity

Martinez-Espinosa, P. L., Yang, C., Gonzalez-Perez, V., Xia, X. M. & Lingle, C. J., 2014, In: Journal of General Physiology. 144, 4, p. 275-295 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

The Ca²⁺-activated K⁺ current of human sperm is mediated by Slo3

Brenker, C., Zhou, Y., Müller, A., Echeverry, F. A., Trötschel, C., Poetsch, A., Xia, X. M., Bönigk, W., Lingle, C. J., Kaupp, U. B. & Strünker, T., Mar 26 2014, In: eLife. 2014, 3, e01438.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

2013

Simultaneous knockout of slo3 and catsper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa

Zeng, X. H., Navarro, B., Xia, X. M., Clapham, D. E. & Lingle, C. J., 2013, In: Journal of General Physiology. 142, 3, p. 305-313 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

2011

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region

Zhou, Y., Xia, X. M. & Lingle, C. J., Jul 19 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 29, p. 12161-12166 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

Deletion of the Slo3 gene abolishes alkalizationactivated K⁺ current in mouse spermatozoa

Zeng, X. H., Yang, C., Kim, S. T., Lingle, C. J. & Xia, X. M., Apr 5 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5879-5884 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

162 Scopus citations

LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel

Yang, C., Zeng, X. H., Zhou, Y., Xia, X. M. & Lingle, C. J., Nov 29 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 48, p. 19419-19424 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

2010

Inhibition of large-conductance Ca²⁺-activated K⁺ channels by nanomolar concentrations of Ag⁺

Zhou, Y., Xia, X. & Lingle, C. J., Nov 2010, In: Molecular pharmacology. 78, 5, p. 952-960 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2009

Interactions between β subunits of the KCNMB family and Slo3: β4 selectively modulates Slo3 expression and function

Yang, C. T., Zeng, X. H., Xia, X. M. & Lingle, C. J., Jul 3 2009, In: PloS one. 4, 7, e6135.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

N-terminal inactivation domains of βsubunits are protected from trypsin digestion by binding within the antechamber of BK channels

Zhang, Z., Zeng, X. H., Xia, X. M. & Lingle, C. J., Mar 2009, In: Journal of General Physiology. 133, 3, p. 263-282 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2008

Species-specific differences among KCNMB3 BK β3 auxiliary subunits: Some β3 N-terminal variants may be primate-specific subunits

Zeng, X., Xia, X. M. & Lingle, C. J., Jul 2008, In: Journal of General Physiology. 132, 1, p. 115-129 15 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2007

BK channels with β3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism

Zeng, X. H., Benzinger, G. R., Xia, X. M. & Lingle, C. J., Apr 25 2007, In: Journal of Neuroscience. 27, 17, p. 4707-4715 9 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2006

A limited access compartment between the pore domain and cytosolic domain of the BK channel

Zhang, Z., Zhou, Y., Ding, J. P., Xia, X. M. & Lingle, C. J., Nov 15 2006, In: Journal of Neuroscience. 26, 46, p. 11833-11843 11 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Direct observation of a preinactivated, open state in BK channels with β2 subunits

Benzinger, G. R., Xia, X. M. & Lingle, C. J., Feb 2006, In: Journal of General Physiology. 127, 2, p. 119-131 13 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

pH-regulated Slo3 K⁺ channels: Properties of unitary currents

Zhang, X., Zeng, X., Xia, X. M. & Lingle, C. J., Sep 2006, In: Journal of General Physiology. 128, 3, p. 301-315 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2005

Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites

Zeng, X. H., Xia, X. M. & Lingle, C. J., Mar 2005, In: Journal of General Physiology. 125, 3, p. 273-286 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

2004

Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains

Xia, X. M., Zhang, X. & Lingle, C. J., Jun 16 2004, In: Journal of Neuroscience. 24, 24, p. 5585-5591 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

2003

Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: A microelectroporation study in adult rodents

Wei, F., Xia, X. M., Tang, J., Ao, H., Ko, S., Liauw, J., Qiu, C. S. & Zhuo, M., Sep 10 2003, In: Journal of Neuroscience. 23, 23, p. 8402-8409 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

Inactivation of BK channels by the NH₂ terminus of the β2 auxiliary subunit: An essential role of a terminal peptide segment of three hydrophobic residues

Xia, X. M., Ding, J. P. & Lingle, C. J., Feb 1 2003, In: Journal of General Physiology. 121, 2, p. 125-148 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Redox-sensitive extracellular gates formed by auxiliary β subunits of calcium-activated potassium channels

Zeng, X. H., Xia, X. M. & Lingle, C. J., Jun 1 2003, In: Nature Structural Biology. 10, 6, p. 448-454 7 p.

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

2002

Consequences of the stoichiometry of Slo1, α and auxiliary β subunits on functional properties of large-conductance Ca²⁺-activated K⁺ channels

Wang, Y. W., Ding, J. P., Xia, X. M. & Lingle, C. J., Mar 1 2002, In: Journal of Neuroscience. 22, 5, p. 1550-1561 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

Multiple regulatory sites in large-conductance calcium-activated potassium channels

Xia, X. M., Zeng, X. & Lingle, C. J., Aug 22 2002, In: Nature. 418, 6900, p. 880-884 5 p.

Research output: Contribution to journal › Article › peer-review

320 Scopus citations

2001

Gating properties conferred on BK channels by the β3b auxiliary subunit in the absence of its NH₂- and COOH termini

Zeng, X. H., Ding, J. P., Xia, X. M. & Lingle, C. J., 2001, In: Journal of General Physiology. 117, 6, p. 607-627 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Inactivation of BK channels mediated by the NH₂ terminus of the β3b auxiliary subunit involves a two-step mechanism: Possible separation of binding and blockade

Lingle, C. J., Zeng, X. H., Ding, J. P. & Xia, X. M., 2001, In: Journal of General Physiology. 117, 6, p. 583-605 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

2000

Rectification and rapid activation at low Ca²⁺ of Ca²⁺-activated, voltage-dependent BK currents: Consequences of rapid inactivation by a novel β subunit

Xia, X. M., Ding, J. P., Zeng, X. H., Duan, K. L. & Lingle, C. J., Jul 1 2000, In: Journal of Neuroscience. 20, 13, p. 4890-4903 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

155 Scopus citations

1999

Molecular basis for the inactivation of Ca²⁺- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells

Xia, X. M., Ding, J. P. & Lingle, C. J., Jul 1 1999, In: Journal of Neuroscience. 19, 13, p. 5255-5264 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

239 Scopus citations

1998

dSLo interacting protein 1, a novel protein that interacts with large- conductance calcium-activated potassium channels

Xia, X. M., Hirschberg, B., Smolik, S., Forte, M. & Adelman, J. P., Apr 1 1998, In: Journal of Neuroscience. 18, 7, p. 2360-2369 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Mechanism of calcium gating in small-conductance calcium-activated potassium channels

Xia, X. M., Fakler, B., Rivard, A., Wayman, G., Johnson-Pais, T., Keen, J. E., Ishii, T., Hirschberg, B., Bond, C. T., Lutsenko, S., Maylie, J. & Adelman, J. P., Oct 1 1998, In: Nature. 395, 6701, p. 503-507 5 p.

Research output: Contribution to journal › Article › peer-review

780 Scopus citations

Site-directed mutagenesis

Ishii, T. M., Zerr, P., Xia, X. M., Bond, C. T., Maylie, J. & Adelman, J. P., 1998, In: Methods in enzymology. 293, p. 53-71 19 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

1996

Inward rectifier potassium channels: Cloning, expression and structure-function studies

Lagrutta, A. A., Bond, C. T., Xia, X. M., Pessia, M., Tucker, S. & Adelman, J. P., Sep 1996, In: Japanese Heart Journal. 37, 5, p. 651-660 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Xiaoming Xia

Research output

Search results