Xiaoming Xia

2020

The functionally relevant site for paxilline inhibition of BK channels

Zhou, Y., Xia, X. M. & Lingle, C. J., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 1021-1026 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2019

LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells

Lingle, C. J., Martinez-Espinosa, P. L., Yang-Hood, A., Boero, L. E., Payne, S., Persic, D., V-Ghaffari, B., Xiao, M., Zhou, Y., Xia, X. M., Pyott, S. J. & Rutherford, M. A., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18397-18403 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Sodium-activated potassium channels moderate excitability in vascular smooth muscle

Li, P., Halabi, C. M., Stewart, R., Butler, A., Brown, B., Xia, X., Santi, C., England, S., Ferreira, J., Mecham, R. P. & Salkoff, L., Oct 1 2019, In : Journal of Physiology. 597, 20, p. 5093-5108 16 p.

Research output: Contribution to journal › Article › peer-review

Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice

Reijntjes, D. O. J., Lee, J. H., Park, S., Schubert, N. M. A., van Tuinen, M., Vijayakumar, S., Jones, T. A., Jones, S. M., Gratton, M. A., Xia, X. M., Yamoah, E. N. & Pyott, S. J., Dec 1 2019, In : Scientific reports. 9, 1, 2573.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2018

BK channel inhibition by strong extracellular acidification

Zhou, Y., Xia, X. M. & Lingle, C. J., Jul 2 2018, In : eLife. 7, e38060.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Regulatory γ1 subunits defy symmetry in functional modulation of BK channels

Gonzalez-Perez, V., Johny, M. B., Xia, X. M. & Lingle, C. J., Oct 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 9923-9928 6 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2017

Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells

Yang, C., Gonzalez-Perez, V., Mukaibo, T., Melvin, J. E., Xia, X. M. & Lingle, C. J., May 2 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 18, p. E3739-E3747

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2016

Cardiac Slo2.1 is required for volatile anesthetic stimulation of K+ transport and anesthetic preconditioning

Wojtovich, A. P., Smith, C. O., Urciuoli, W. R., Wang, Y. T., Xia, X. M., Brookes, P. S. & Nehrke, K., May 1 2016, In : Anesthesiology. 124, 5, p. 1065-1076 12 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2015

Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications

Zhou, Y., Xia, X. M. & Lingle, C. J., Apr 21 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 16, p. 5237-5242 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Knockout of Slo2.2 enhances itch, abolishes K_Na current, and increases action potential firing frequency in DRG neurons

Martinez-Espinosa, P. L., Wu, J., Yang, C., Gonzalez-Perez, V., Zhou, H., Liang, H., Xia, X. M. & Lingle, C. J., Nov 11 2015, In : eLife. 4, NOVEMBER2015, e10013.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility

Zeng, X. H., Yang, C., Xia, X. M., Liua, M. & Lingle, C. J., Feb 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. 2599-2604 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating

Gonzalez-Perez, V., Xia, X. M. & Lingle, C. J., Sep 21 2015, In : Nature communications. 6, 8341.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2014

Functional regulation of BK potassium channels by γ1 auxiliary subunits

Gonzalez-Perez, V., Xia, X. M. & Lingle, C. J., Apr 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 13, p. 4868-4873 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity

Martinez-Espinosa, P. L., Yang, C., Gonzalez-Perez, V., Xia, X. M. & Lingle, C. J., 2014, In : Journal of General Physiology. 144, 4, p. 275-295 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

The Ca²⁺-activated K⁺ current of human sperm is mediated by Slo3

Brenker, C., Zhou, Y., Müller, A., Echeverry, F. A., Trötschel, C., Poetsch, A., Xia, X. M., Bönigk, W., Lingle, C. J., Kaupp, U. B. & Strünker, T., Mar 26 2014, In : eLife. 2014, 3, e01438.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

2013

Simultaneous knockout of slo3 and catsper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa

Zeng, X. H., Navarro, B., Xia, X. M., Clapham, D. E. & Lingle, C. J., 2013, In : Journal of General Physiology. 142, 3, p. 305-313 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2011

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region

Zhou, Y., Xia, X. M. & Lingle, C. J., Jul 19 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 29, p. 12161-12166 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Deletion of the Slo3 gene abolishes alkalizationactivated K⁺ current in mouse spermatozoa

Zeng, X. H., Yang, C., Kim, S. T., Lingle, C. J. & Xia, X. M., Apr 5 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5879-5884 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel

Yang, C., Zeng, X. H., Zhou, Y., Xia, X. M. & Lingle, C. J., Nov 29 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 48, p. 19419-19424 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2010

Inhibition of large-conductance Ca²⁺-activated K⁺ channels by nanomolar concentrations of Ag⁺

Zhou, Y., Xia, X. & Lingle, C. J., Nov 2010, In : Molecular pharmacology. 78, 5, p. 952-960 9 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2009

Interactions between β subunits of the KCNMB family and Slo3: β4 selectively modulates Slo3 expression and function

Yang, C. T., Zeng, X. H., Xia, X. M. & Lingle, C. J., Jul 3 2009, In : PloS one. 4, 7, e6135.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

N-terminal inactivation domains of βsubunits are protected from trypsin digestion by binding within the antechamber of BK channels

Zhang, Z., Zeng, X. H., Xia, X. M. & Lingle, C. J., Mar 2009, In : Journal of General Physiology. 133, 3, p. 263-282 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2008

Species-specific differences among KCNMB3 BK β3 auxiliary subunits: Some β3 N-terminal variants may be primate-specific subunits

Zeng, X., Xia, X. M. & Lingle, C. J., Jul 2008, In : Journal of General Physiology. 132, 1, p. 115-129 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2007

BK channels with β3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism

Zeng, X. H., Benzinger, G. R., Xia, X. M. & Lingle, C. J., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4707-4715 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2006

A limited access compartment between the pore domain and cytosolic domain of the BK channel

Zhang, Z., Zhou, Y., Ding, J. P., Xia, X. M. & Lingle, C. J., Nov 15 2006, In : Journal of Neuroscience. 26, 46, p. 11833-11843 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Direct observation of a preinactivated, open state in BK channels with β2 subunits

Benzinger, G. R., Xia, X. M. & Lingle, C. J., Feb 2006, In : Journal of General Physiology. 127, 2, p. 119-131 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

pH-regulated Slo3 K⁺ channels: Properties of unitary currents

Zhang, X., Zeng, X., Xia, X. M. & Lingle, C. J., Sep 2006, In : Journal of General Physiology. 128, 3, p. 301-315 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2005

Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites

Zeng, X. H., Xia, X. M. & Lingle, C. J., Mar 2005, In : Journal of General Physiology. 125, 3, p. 273-286 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

99 Scopus citations

2004

Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains

Xia, X. M., Zhang, X. & Lingle, C. J., Jun 16 2004, In : Journal of Neuroscience. 24, 24, p. 5585-5591 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

2003

Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: A microelectroporation study in adult rodents

Wei, F., Xia, X. M., Tang, J., Ao, H., Ko, S., Liauw, J., Qiu, C. S. & Zhuo, M., Sep 10 2003, In : Journal of Neuroscience. 23, 23, p. 8402-8409 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Inactivation of BK channels by the NH₂ terminus of the β2 auxiliary subunit: An essential role of a terminal peptide segment of three hydrophobic residues

Xia, X. M., Ding, J. P. & Lingle, C. J., Feb 1 2003, In : Journal of General Physiology. 121, 2, p. 125-148 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Redox-sensitive extracellular gates formed by auxiliary β subunits of calcium-activated potassium channels

Zeng, X. H., Xia, X. M. & Lingle, C. J., Jun 1 2003, In : Nature Structural Biology. 10, 6, p. 448-454 7 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

2002

Consequences of the stoichiometry of Slo1, α and auxiliary β subunits on functional properties of large-conductance Ca²⁺-activated K⁺ channels

Wang, Y. W., Ding, J. P., Xia, X. M. & Lingle, C. J., Mar 1 2002, In : Journal of Neuroscience. 22, 5, p. 1550-1561 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

Multiple regulatory sites in large-conductance calcium-activated potassium channels

Xia, X. M., Zeng, X. & Lingle, C. J., Aug 22 2002, In : Nature. 418, 6900, p. 880-884 5 p.

Research output: Contribution to journal › Article › peer-review

277 Scopus citations

2001

Gating properties conferred on BK channels by the β3b auxiliary subunit in the absence of its NH₂- and COOH termini

Zeng, X. H., Ding, J. P., Xia, X. M. & Lingle, C. J., 2001, In : Journal of General Physiology. 117, 6, p. 607-627 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Inactivation of BK channels mediated by the NH₂ terminus of the β3b auxiliary subunit involves a two-step mechanism: Possible separation of binding and blockade

Lingle, C. J., Zeng, X. H., Ding, J. P. & Xia, X. M., 2001, In : Journal of General Physiology. 117, 6, p. 583-605 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2000

Rectification and rapid activation at low Ca²⁺ of Ca²⁺-activated, voltage-dependent BK currents: Consequences of rapid inactivation by a novel β subunit

Xia, X. M., Ding, J. P., Zeng, X. H., Duan, K. L. & Lingle, C. J., Jul 1 2000, In : Journal of Neuroscience. 20, 13, p. 4890-4903 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

1999

Molecular basis for the inactivation of Ca²⁺- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells

Xia, X. M., Ding, J. P. & Lingle, C. J., Jul 1 1999, In : Journal of Neuroscience. 19, 13, p. 5255-5264 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

221 Scopus citations

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