Xiaobo Wu

2021

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

Ma, L., Sahu, S. K., Cano, M., Kuppuswamy, V., Bajwa, J., McPhatter, JN., Pine, A., Meizlish, M. L., Goshua, G., Chang, C. H., Zhang, H., Price, C., Bahel, P., Rinder, H., Lei, T., Day, A., Reynolds, D., Wu, X., Schriefer, R., Rauseo, A. M. & 11 others, Goss, C. W., O'Halloran, J. A., Presti, R. M., Kim, A. H., Gelman, A. E., Dela Cruz, C. S., Lee, A. I., Mudd, P. A., Chun, H. J., Atkinson, J. P. & Kulkarni, H. S., May 2021, In: Science immunology. 6, 59, eabh2259.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2019

Complement activation on neutrophils initiates endothelial adhesion and extravasation

Akk, A., Springer, L. E., Yang, L., Hamilton-Burdess, S., Lambris, J. D., Yan, H., Hu, Y., Wu, X., Hourcade, D. E., Miller, M. J. & Pham, C. T. N., Oct 2019, In: Molecular Immunology. 114, p. 629-642 14 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Fat-Produced Adipsin Regulates Inflammatory Arthritis

Li, Y., Zou, W., Brestoff, J. R., Rohatgi, N., Wu, X., Atkinson, J. P., Harris, C. A. & Teitelbaum, S. L., Jun 4 2019, In: Cell Reports. 27, 10, p. 2809-2816.e3

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility

Lee, A. S., Rusch, J., Lima, A. C., Usmani, A., Huang, N., Lepamets, M., Vigh-Conrad, K. A., Worthington, R. E., Mägi, R., Wu, X., Aston, K. I., Atkinson, J. P., Carrell, D. T., Hess, R. A., O’Bryan, M. K. & Conrad, D. F., Dec 1 2019, In: Nature communications. 10, 1, 4626.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2018

Contribution of adipose-derived factor D/Adipsin to complement alternative pathway activation: Lessons from lipodystrophy

Wu, X., Hutson, I., Akk, A. M., Mascharak, S., Pham, C. T. N., Hourcade, D. E., Brown, R., Atkinson, J. P. & Harris, C. A., Apr 15 2018, In: Journal of Immunology. 200, 8, p. 2786-2797 12 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse

Triebwasser, M. P., Wu, X., Bertram, P., Hourcade, D. E., Nelson, D. M. & Atkinson, J. P., Oct 2018, In: American Journal of Reproductive Immunology. 80, 4, e12997.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2016

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells

Sherbenou, D. W., Aftab, B. T., Su, Y., Behrens, C. R., Wiita, A., Logan, A. C., Acosta-Alvear, D., Hann, B. C., Walter, P., Shuman, M. A., Wu, X., Atkinson, J. P., Wolf, J. L., Martin, T. G. & Liu, B., Dec 1 2016, In: Journal of Clinical Investigation. 126, 12, p. 4640-4653 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration–Like Phenotype

Lyzogubov, V. V., Bora, P. S., Wu, X., Horn, L. E., de Roque, R., Rudolf, X. V., Atkinson, J. P. & Bora, N. S., Aug 1 2016, In: American Journal of Pathology. 186, 8, p. 2088-2104 17 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2014

Complement regulatory protein CD46 protects against choroidal neovascularization in mice

Lyzogubov, V., Wu, X., Jha, P., Tytarenko, R., Triebwasser, M., Kolar, G., Bertram, P., Bora, P. S., Atkinson, J. P. & Bora, N. S., Sep 2014, In: American Journal of Pathology. 184, 9, p. 2537-2548 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis

Pinto, A. K., Ramos, H. J., Wu, X., Aggarwal, S., Shrestha, B., Gorman, M., Kim, K. Y., Suthar, M. S., Atkinson, J. P., Gale, M. & Diamond, M. S., Apr 2014, In: PLoS pathogens. 10, 4, e1004086.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

2013

Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis

Zou, L., Feng, Y., Li, Y., Zhang, M., Chen, C., Cai, J., Gong, Y., Wang, L., Thurman, J. M., Wu, X., Atkinson, J. P. & Chao, W., Dec 1 2013, In: Journal of Immunology. 191, 11, p. 5625-5635 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

2012

Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm

Zhou, H. F., Yan, H., Stover, C. M., Fernandez, T. M., Rodriguez De Cordoba, S., Song, W. C., Wu, X., Thompson, R. W., Schwaeble, W. J., Atkinson, J. P., Hourcade, D. E. & Pham, C. T. N., Feb 14 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. E415-E422

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

Ramaglia, V., Hughes, T. R., Donev, R. M., Ruseva, M. M., Wu, X., Huitinga, I., Baas, F., Neal, J. W. & Morgan, B. P., Jan 17 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 965-970 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis

Soltys, J. & Wu, X., 2012, In: Journal of Inflammation (United Kingdom). 9, 20.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2011

Erratum: Properdin homeostasis requires turnover of the alternative complement pathway (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 45 (19444-19448) DOI: 10.1073/pnas.1006608107)

Wu, X., Xu, T. Q. & Atkinson, J. P., Jun 21 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 25, p. 10372 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation

Baldo, G., Wu, S., Howe, R. A., Ramamoothy, M., Knutsen, R. H., Fang, J., Mecham, R. P., Liu, Y., Wu, X., Atkinson, J. P. & Ponder, K. P., Dec 2011, In: Molecular genetics and metabolism. 104, 4, p. 608-619 12 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

2010

Properdin homeostasis requires turnover of the alternative complement pathway

Wu, X., Xu, T. Q. & Atkinson, J. P., Nov 9 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19444-19448 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2009

Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm

Pagano, M. B., Zhou, H. F., Ennis, T. L., Wu, X., Lambris, J. D., Atkinson, J. P., Thompson, R. W., Hourcade, D. E. & Pham, C. T. N., Apr 7 2009, In: Circulation. 119, 13, p. 1805-1813 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury

Ruseva, M. M., Hughes, T. R., Donev, R. M., Sivasankar, B., Pickering, M. C., Wu, X., Harris, C. L. & Morgan, B. P., Feb 2009, In: Molecular Immunology. 46, 5, p. 803-811 9 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2008

Membrane protein Crry maintains homeostasis of the complement system

Wu, X., Spitzer, D., Mao, D., Peng, S. L., Molina, H. & Atkinson, J. P., Aug 15 2008, In: Journal of Immunology. 181, 4, p. 2732-2740 9 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2007

Systemic humoral autoimmunity but joint-specific inflammation: The syndrome of rheumatoid arthritis

Wu, X., Shih, F. & Atkinson, J. P., Sep 2007, In: Arthritis and rheumatism. 56, 9, p. 2823-2828 6 p.

Research output: Contribution to journal › Editorial

Open Access

3 Scopus citations

2006

Cutting edge: Treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy

Spitzer, D., Wu, X., Ma, X., Xu, L., Ponder, K. P. & Atkinson, J. P., Oct 15 2006, In: Journal of Immunology. 177, 8, p. 4953-4956 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Toll-like receptor 9 signaling protects against murine lupus

Wu, X. & Peng, S. L., Jan 2006, In: Arthritis and rheumatism. 54, 1, p. 336-342 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

190 Scopus citations

2005

In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane

Spitzer, D., Unsinger, J., Mao, D., Wu, X., Molina, H. & Atkinson, J. P., Dec 1 2005, In: Journal of Immunology. 175, 11, p. 7763-7770 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2003

Negligible Role of Antibodies and C5 in Pregnancy Loss Associated Exclusively with C3-Dependent Mechanisms through Complement Alternative Pathway

Mao, D., Wu, X., Deppong, C., Friend, L. D., Dolecki, G., Nelson, D. M. & Molina, H., Dec 2003, In: Immunity. 19, 6, p. 813-822 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

2002

A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus

Wu, X., Jiang, N., Deppong, C., Singh, J., Dolecki, G., Mao, D., Morel, L. & Molina, H. D., Aug 1 2002, In: Journal of Immunology. 169, 3, p. 1587-1592 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

2000

Impaired affinity maturation in Cr2(-/-) mice is rescued by adjuvants without improvement in germinal center development

Wu, X., Jiang, N., Fang, Y. F., Xu, C., Mao, D., Singh, J., Fu, Y. X. & Molina, H., Sep 15 2000, In: Journal of Immunology. 165, 6, p. 3119-3127 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Scopus citations

1997

Chemokines Are Expressed in a Myeloid Cell-Dependent Fashion and Mediate Distinct Functions in Immune Complex Glomerulonephritis in Rat

Wu, X., Dolecki, G. J., Sherry, B., Zagorski, J. & Lefkowith, J. B., Apr 15 1997, In: Journal of Immunology. 158, 8, p. 3917-3924 8 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

1996

Differing roles of CD18 and VLA-4 in leukocyte migration/activation during anti-GBM nephritis

Wu, X., Tiwari, A. K., Issekutz, T. B. & Lefkowith, J. B., 1996, In: Kidney International. 50, 2, p. 462-472 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

1995

GRO chemokines: A transduction, integration, and amplification mechanism in acute renal inflammation

Wu, X., Dolecki, G. J. & Lefkowith, J. B., 1995, In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 269, 2 38-2, p. F248-F256

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

1994

Cytokine-induced neutrophil chemoattractant mediates neutrophil influx in immune complex glomerulonephritis in rat

Wu, X., Wittwer, A. J., Carr, L. S., Crippes, B. A., DeLarco, J. E. & Lefkowith, J. B., Jul 1994, In: Journal of Clinical Investigation. 94, 1, p. 337-344 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access