Research output per year
Research output per year
- 38 results
Search results
-
2025
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Collins, K. H., Lenz, K. L., Welhaven, H. D., Ely, E., Springer, L. E., Paradi, S., Tang, R., Braxton, L., Akk, A., Yan, H., Zhang, B., Wu, X., Atkinson, J. P., Oestreich, A. K., June, R. K., Pham, C. T. N. & Guilak, F., Apr 25 2025, In: Science Advances. 11, 17, eadt5915.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Atypical hemolytic uremic syndrome: genetically-based insights into pathogenesis through an analysis of the complement regulator CD46
Wu, X., Kathryn Liszewski, M., Java, A. & Atkinson, J. P., Sep 30 2023, In: Annals of Blood. 8Research output: Contribution to journal › Review article › peer-review
Open Access -
Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury
Sahu, S. K., Ozantürk, A. N., Kulkarni, D. H., Ma, L., Barve, R. A., Dannull, L., Lu, A., Starick, M., McPhatter, J., Garnica, L., Sanfillipo-Burchman, M., Kunen, J., Wu, X., Gelman, A. E., Brody, S. L., Atkinson, J. P. & Kulkarni, H. S., Feb 2023, In: Science immunology. 8, 80, eabp9547.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2021
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Ma, L., Sahu, S. K., Cano, M., Kuppuswamy, V., Bajwa, J., McPhatter, J., Pine, A., Meizlish, M. L., Goshua, G., Chang, C. H., Zhang, H., Price, C., Bahel, P., Rinder, H., Lei, T., Day, A., Reynolds, D., Wu, X., Schriefer, R. & Rauseo, A. M. & 11 others, , May 2021, In: Science immunology. 6, 59, eabh2259.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
2019
Complement activation on neutrophils initiates endothelial adhesion and extravasation
Akk, A., Springer, L. E., Yang, L., Hamilton-Burdess, S., Lambris, J. D., Yan, H., Hu, Y., Wu, X., Hourcade, D. E., Miller, M. J. & Pham, C. T. N., Oct 2019, In: Molecular Immunology. 114, p. 629-642 14 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Fat-Produced Adipsin Regulates Inflammatory Arthritis
Li, Y., Zou, W., Brestoff, J. R., Rohatgi, N., Wu, X., Atkinson, J. P., Harris, C. A. & Teitelbaum, S. L., Jun 4 2019, In: Cell Reports. 27, 10, p. 2809-2816.e3Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility
Lee, A. S., Rusch, J., Lima, A. C., Usmani, A., Huang, N., Lepamets, M., Vigh-Conrad, K. A., Worthington, R. E., Mägi, R., Wu, X., Aston, K. I., Atkinson, J. P., Carrell, D. T., Hess, R. A., O’Bryan, M. K. & Conrad, D. F., Dec 1 2019, In: Nature communications. 10, 1, 4626.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
The Human Complement System
Atkinson, J., Du Clos, T. W., Mold, C., Kulkarni, H., Hourcade, D. & Wu, X., Jan 1 2019, Clinical Immunology: Principles and Practice. Elsevier, p. 299-317.e1Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
17 Scopus citations -
2018
Contribution of adipose-derived factor D/Adipsin to complement alternative pathway activation: Lessons from lipodystrophy
Wu, X., Hutson, I., Akk, A. M., Mascharak, S., Pham, C. T. N., Hourcade, D. E., Brown, R., Atkinson, J. P. & Harris, C. A., Apr 15 2018, In: Journal of Immunology. 200, 8, p. 2786-2797 12 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse
Triebwasser, M. P., Wu, X., Bertram, P., Hourcade, D. E., Nelson, D. M. & Atkinson, J. P., Oct 2018, In: American Journal of Reproductive Immunology. 80, 4, e12997.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2016
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells
Sherbenou, D. W., Aftab, B. T., Su, Y., Behrens, C. R., Wiita, A., Logan, A. C., Acosta-Alvear, D., Hann, B. C., Walter, P., Shuman, M. A., Wu, X., Atkinson, J. P., Wolf, J. L., Martin, T. G. & Liu, B., Dec 1 2016, In: Journal of Clinical Investigation. 126, 12, p. 4640-4653 14 p.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration–Like Phenotype
Lyzogubov, V. V., Bora, P. S., Wu, X., Horn, L. E., de Roque, R., Rudolf, X. V., Atkinson, J. P. & Bora, N. S., Aug 1 2016, In: American Journal of Pathology. 186, 8, p. 2088-2104 17 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
2014
Complement regulatory protein CD46 protects against choroidal neovascularization in mice
Lyzogubov, V., Wu, X., Jha, P., Tytarenko, R., Triebwasser, M., Kolar, G., Bertram, P., Bora, P. S., Atkinson, J. P. & Bora, N. S., Sep 2014, In: American Journal of Pathology. 184, 9, p. 2537-2548 12 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis
Pinto, A. K., Ramos, H. J., Wu, X., Aggarwal, S., Shrestha, B., Gorman, M., Kim, K. Y., Suthar, M. S., Atkinson, J. P., Gale, M. & Diamond, M. S., Apr 2014, In: PLoS pathogens. 10, 4, e1004086.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
2013
Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis
Zou, L., Feng, Y., Li, Y., Zhang, M., Chen, C., Cai, J., Gong, Y., Wang, L., Thurman, J. M., Wu, X., Atkinson, J. P. & Chao, W., Dec 1 2013, In: Journal of Immunology. 191, 11, p. 5625-5635 11 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
2012
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm
Zhou, H. F., Yan, H., Stover, C. M., Fernandez, T. M., Rodriguez De Cordoba, S., Song, W. C., Wu, X., Thompson, R. W., Schwaeble, W. J., Atkinson, J. P., Hourcade, D. E. & Pham, C. T. N., Feb 14 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. E415-E422Research output: Contribution to journal › Article › peer-review
Open Access67 Scopus citations -
C3-dependent mechanism of microglial priming relevant to multiple sclerosis
Ramaglia, V., Hughes, T. R., Donev, R. M., Ruseva, M. M., Wu, X., Huitinga, I., Baas, F., Neal, J. W. & Morgan, B. P., Jan 17 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 965-970 6 p.Research output: Contribution to journal › Article › peer-review
Open Access128 Scopus citations -
Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis
Soltys, J. & Wu, X., 2012, In: Journal of Inflammation (United Kingdom). 9, 20.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2011
Erratum: Properdin homeostasis requires turnover of the alternative complement pathway (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 45 (19444-19448) DOI: 10.1073/pnas.1006608107)
Wu, X., Xu, T. Q. & Atkinson, J. P., Jun 21 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 25, p. 10372 1 p.Research output: Contribution to journal › Comment/debate
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Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation
Baldo, G., Wu, S., Howe, R. A., Ramamoothy, M., Knutsen, R. H., Fang, J., Mecham, R. P., Liu, Y., Wu, X., Atkinson, J. P. & Ponder, K. P., Dec 2011, In: Molecular genetics and metabolism. 104, 4, p. 608-619 12 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
2010
Properdin homeostasis requires turnover of the alternative complement pathway
Wu, X., Xu, T. Q. & Atkinson, J. P., Nov 9 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19444-19448 5 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2009
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm
Pagano, M. B., Zhou, H. F., Ennis, T. L., Wu, X., Lambris, J. D., Atkinson, J. P., Thompson, R. W., Hourcade, D. E. & Pham, C. T. N., Apr 7 2009, In: Circulation. 119, 13, p. 1805-1813 9 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury
Ruseva, M. M., Hughes, T. R., Donev, R. M., Sivasankar, B., Pickering, M. C., Wu, X., Harris, C. L. & Morgan, B. P., Feb 2009, In: Molecular Immunology. 46, 5, p. 803-811 9 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
2008
Membrane protein Crry maintains homeostasis of the complement system
Wu, X., Spitzer, D., Mao, D., Peng, S. L., Molina, H. & Atkinson, J. P., Aug 15 2008, In: Journal of Immunology. 181, 4, p. 2732-2740 9 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2007
Systemic humoral autoimmunity but joint-specific inflammation: The syndrome of rheumatoid arthritis
Wu, X., Shih, F. & Atkinson, J. P., Sep 2007, In: Arthritis and rheumatism. 56, 9, p. 2823-2828 6 p.Research output: Contribution to journal › Editorial
3 Scopus citations -
2006
Cutting edge: Treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy
Spitzer, D., Wu, X., Ma, X., Xu, L., Ponder, K. P. & Atkinson, J. P., Oct 15 2006, In: Journal of Immunology. 177, 8, p. 4953-4956 4 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Toll-like receptor 9 signaling protects against murine lupus
Wu, X. & Peng, S. L., Jan 2006, In: Arthritis and rheumatism. 54, 1, p. 336-342 7 p.Research output: Contribution to journal › Article › peer-review
199 Scopus citations -
2005
In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane
Spitzer, D., Unsinger, J., Mao, D., Wu, X., Molina, H. & Atkinson, J. P., Dec 1 2005, In: Journal of Immunology. 175, 11, p. 7763-7770 8 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2003
Negligible Role of Antibodies and C5 in Pregnancy Loss Associated Exclusively with C3-Dependent Mechanisms through Complement Alternative Pathway
Mao, D., Wu, X., Deppong, C., Friend, L. D., Dolecki, G., Nelson, D. M. & Molina, H., Dec 2003, In: Immunity. 19, 6, p. 813-822 10 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
2002
A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus
Wu, X., Jiang, N., Deppong, C., Singh, J., Dolecki, G., Mao, D., Morel, L. & Molina, H. D., Aug 1 2002, In: Journal of Immunology. 169, 3, p. 1587-1592 6 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Scopus citations -
2000
Impaired affinity maturation in Cr2(-/-) mice is rescued by adjuvants without improvement in germinal center development
Wu, X., Jiang, N., Fang, Y. F., Xu, C., Mao, D., Singh, J., Fu, Y. X. & Molina, H., Sep 15 2000, In: Journal of Immunology. 165, 6, p. 3119-3127 9 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
1997
Chemokines Are Expressed in a Myeloid Cell-Dependent Fashion and Mediate Distinct Functions in Immune Complex Glomerulonephritis in Rat
Wu, X., Dolecki, G. J., Sherry, B., Zagorski, J. & Lefkowith, J. B., Apr 15 1997, In: Journal of Immunology. 158, 8, p. 3917-3924 8 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
1996
Differing roles of CD18 and VLA-4 in leukocyte migration/activation during anti-GBM nephritis
Wu, X., Tiwari, A. K., Issekutz, T. B. & Lefkowith, J. B., 1996, In: Kidney International. 50, 2, p. 462-472 11 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
1995
GRO chemokines: A transduction, integration, and amplification mechanism in acute renal inflammation
Wu, X., Dolecki, G. J. & Lefkowith, J. B., Aug 1995, In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 269, 2 38-2, p. F248-F256Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
1994
Cytokine-induced neutrophil chemoattractant mediates neutrophil influx in immune complex glomerulonephritis in rat
Wu, X., Wittwer, A. J., Carr, L. S., Crippes, B. A., DeLarco, J. E. & Lefkowith, J. B., Jul 1994, In: Journal of Clinical Investigation. 94, 1, p. 337-344 8 p.Research output: Contribution to journal › Article › peer-review
Open Access110 Scopus citations -
Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats
Wu, X., Helfrich, M. H., Horton, M. A., Feigen, L. P. & Lefkowith, J. B., Sep 1994, In: Journal of Clinical Investigation. 94, 3, p. 928-936 9 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
1993
Attenuation of immune-mediated glomerulonephritis with an anti-CD11b monoclonal antibody
Wu, X., Pippin, J. & Lefkowith, J. B., 1993, In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 264, 4 33-4, p. F715-F721Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Platelets and neutrophils are critical to the enhanced glomerular arachidonate metabolism in acute nephrotoxic nephritis in rats
Wu, X., Pippin, J. & Lefkowith, J. B., Mar 1993, In: Journal of Clinical Investigation. 91, 3, p. 766-773 8 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations